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公开(公告)号：JP2011173890A
公开(公告)日：2011-09-08
申请号：JP2011070629
申请日：2011-03-28
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM
IPC: A61K31/437 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/495 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/655 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/78 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide medicaments useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. SOLUTION: There are provided compounds of formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification, wherein X is N or CR 10 , Y is NR 3 , O, S, S(O), S(O) 2 , C(O) or CH 2 , R 1 , R 2 R 8 , R 9 and R 10 are independently, hydrogen, hydroxy, halogen, or others. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds are also provided. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 待解决的问题：提供可用于治疗哺乳动物中过度增生性疾病如癌症和炎症的药物。 提供式I化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 2，R 7， ，其中X是N或CR，其中X是X，Y，X，Y，X和Y如说明书中所定义，其中X是N或CR 10， C（O）或CH
2 ，S（O），S（O） > 1 ，R 2 R 8 ，R 9 和R 10 独立地是氢， 羟基，卤素等。 这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。 还提供了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。 版权所有（C）2011，JPO＆INPIT -
公开(公告)号：JP2013028637A
公开(公告)日：2013-02-07
申请号：JP2012220857
申请日：2012-10-03
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド , Astrazeneca Ab , アストラゼネカ エービー
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC: C07D213/82 , A61K31/4412 , A61P29/00 , A61P35/00 , A61P43/00
CPC classification number: C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
Abstract: PROBLEM TO BE SOLVED: To provide a compound that is useful for medical treatment of hyperproliferative disease such as cancer and inflammation in mammals and of inflammatory condition, and to provide a pharmaceutical composition including this compound.SOLUTION: There are provided a compound expressed by formula V, and a pharmaceutical composition including this compound. [In the formula, Ris HOCHCHO or (S)-MeCH(OH)CHO; and Ris H, CH, F, or Cl; but when Ris Cl, then R is not HOCHCHO].
Abstract translation: 待解决的问题：提供可用于治疗过度增殖性疾病如哺乳动物和炎性疾病中的癌症和炎症的化合物，并提供包含该化合物的药物组合物。 提供了由式V表示的化合物和包含该化合物的药物组合物。 [在公式中，R
3 是HOCH 2 CH 2 O或 （S）-MeCH（OH）CH 2 O; 并且R 9 是H，CH 3 ，F或Cl; 但是当R 3 为Cl时，则R不为HOCH 2 CH 2 O]。 版权所有（C）2013，JPO＆INPIT -
公开(公告)号：JP2012092151A
公开(公告)日：2012-05-17
申请号：JP2012029242
申请日：2012-02-14
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： WALLACE ELI , YANG HONG WOON , LYSSIKATOS JOSEPH P
IPC: C07D209/46 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/4035 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/44 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical drug which is useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions.SOLUTION: A compound represented by formula (I) and a pharmaceutically acceptable salt and prodrug thereof are disclosed (wherein R, R, R, R, R, R, R, Rand Rare as defined in the specification). Such compound is an MEK inhibitor and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Moreover, a method of using such compound in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compound are disclosed.
Abstract translation: 待解决的问题：提供可用于治疗哺乳动物和炎性病症中的过度增生性疾病如癌症和炎症的药物。 解决方案：公开了由式（I）表示的化合物及其药学上可接受的盐和前药（其中R
1 ，R ，R 7 ，R 8 ，R 9 R 10 ，R 20 ，R 21 ，R 22 如规范中所定义）。 这种化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中过度增生性疾病，如癌症和炎症。 此外，公开了使用这种化合物治疗哺乳动物中过度增殖性疾病的方法和含有该化合物的药物组合物。 版权所有（C）2012，JPO＆INPIT -
公开(公告)号：JP2011153151A
公开(公告)日：2011-08-11
申请号：JP2011070628
申请日：2011-03-28
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM
IPC: C07D213/80 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/495 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/655 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide heterocyclic inhibitors of MEK and to provide methods of use thereof. SOLUTION: There are provided compounds represented by the formula as well as pharmaceutically acceptable salts thereof and prodrugs. In the formula, R 1 , R 2 , R 7 , R 8 , and R 9 are each a hydrogen atom or the like; X and Y are each a nitrogen atom or the like; and W is a heteroaryl group. The compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases and inflammatory conditions such as cancers and inflammations in mammals. Also there are provided methods of use of the compounds and pharmaceutical compositions containing the compounds in the treatment of hyperproliferative diseases in mammals. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 待解决的问题：提供MEK的杂环抑制剂并提供其使用方法。 解决方案：提供由下式表示的化合物及其药学上可接受的盐和前药。 在该式中，R
1 ，R 2 ，R 7 ，R 8 和R 9 各自为氢原子等; X和Y各自为氮原子等; W是杂芳基。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中过度增殖性疾病和炎性疾病如癌症和炎症。 还提供了使用含有化合物的化合物和药物组合物在哺乳动物中过度增殖性疾病的治疗方法。 版权所有（C）2011，JPO＆INPIT -
公开(公告)号：JP2011121984A
公开(公告)日：2011-06-23
申请号：JP2011026680
申请日：2011-02-10
Applicant: Array Biopharma Inc , アレイ バイオファーマ、インコーポレイテッド
Inventor： WALLACE ELI , YANG HONG WOON , LYSSIKATOS JOSEPH P
IPC: C07D237/32 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide compounds that act as MEK inhibitors, useful in the treatment of hyperproliferative diseases such as cancer and inflammation and inflammatory conditions, in mammals; and to provide pharmaceutical compositions containing such compounds. SOLUTION: There are disclosed compounds of formula (II) and pharmaceutical compositions comprising the compounds, (wherein R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 20 , and R 21 are each independently hydrogen, halogen, cyano, nitro, trifluoromethyl, difluoromethyl, fluoromethyl, fluoromethoxy, difluoromethoxy, trifluoromethoxy or the like.). COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 待解决的问题：提供可用于治疗哺乳动物中过度增殖性疾病如癌症和炎症和炎症状态的作为MEK抑制剂的化合物; 并提供含有这些化合物的药物组合物。 解决方案：公开了式（II）的化合物和包含化合物的药物组合物（其中R 1，R 2，R SP 3， SP>，R
8 ，R 9 ，R 10 ，R 20 / SP>各自独立地为氢，卤素，氰基，硝基，三氟甲基，二氟甲基，氟甲基，氟甲氧基，二氟甲氧基，三氟甲氧基等。 版权所有（C）2011，JPO＆INPIT -
Patent Agency Ranking
公开(公告)号：JP2009215312A
公开(公告)日：2009-09-24
申请号：JP2009120619
申请日：2009-05-19
Applicant: Array Biopharma Inc , Astrazeneca Ab , アストラゼネカ エービー , アレイ バイオファーマ、インコーポレイテッド
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC: C07D237/24 , A61K31/50 , A61P29/00 , A61P35/00 , A61P43/00
CPC classification number: C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a composition and a compound inhibiting MEK. SOLUTION: This invention relates to a series of new heterocyclic compounds that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and discloses MEK inhibitors useful in the treatment of inflammatory conditions. A 6-oxo-1,6-dihydropyridazine compound having a specific substituent may include a tautomer, a metabolite, a resolved enantiomer, a diastereomer, a solvate, and a pharmaceutically acceptable salt thereof, and is a strong inhibitor of an MEK enzyme. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 待解决的问题：提供一种制备组合物和抑制MEK的化合物的方法。 解决方案：本发明涉及可用于治疗哺乳动物中过度增生性疾病如癌症和炎症的一系列新的杂环化合物，并且公开了可用于治疗炎性病症的MEK抑制剂。 具有特定取代基的6-氧代-1,6-二氢哒嗪化合物可以包括互变异构体，代谢物，分解的对映异构体，非对映异构体，溶剂化物和药学上可接受的盐，并且是MEK酶的强抑制剂。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：WO2007044084A3
公开(公告)日：2009-04-16
申请号：PCT/US2006019108
申请日：2006-05-17
Applicant: ARRAY BIOPHARMA INC , ASTRAZENECA AB , MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC: A61K31/50 , A61K31/4412 , C07D211/74 , C07D211/86 , C07D213/63 , C07D213/70 , C07D237/12 , C07D237/14
CPC classification number: C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
Abstract: Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Abstract translation: 公开了可用于治疗哺乳动物和炎性病症中过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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8.发明申请CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS 审中-公开CYANOGUANIDINES和CYANOAMIDINES作为ERBB2和EGFR抑制剂
公开(公告)号：WO2004046101A2
公开(公告)日：2004-06-03
申请号：PCT/US0335670
申请日：2003-11-10
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , TOPALOV GEORGE , ZHAO QIAN
IPC: A61P31/18 , A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04 , C07D417/14 , C07D
CPC classification number: C07D417/14 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04
Abstract: Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Use of the compounds of the invention to manufacture therapeutic compositions for the treatment of hyperproliferative diseases in mammals is also disclosed.
Abstract translation: 公开了用于治疗过度增殖性疾病的氰基胍喹唑啉和氰脒喹唑啉衍生物。 还公开了使用本发明的化合物制备用于治疗哺乳动物过度增殖性疾病的治疗组合物。
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公开(公告)号：WO2005051301A3
公开(公告)日：2006-05-18
申请号：PCT/US2004039060
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC , MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM
IPC: A61K31/44 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/02 , C07D231/56 , C07D237/02 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/00 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/00 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/00 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
Abstract: Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Abstract translation: 公开了式（I）的化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 7， SUP> 8和R 9，W，X和Y如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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公开(公告)号：WO2005051302A2
公开(公告)日：2005-06-09
申请号：PCT/US2004039061
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC , WALLACE ELI , YANG HONG WOON , BLAKE JIM
Inventor： WALLACE ELI , YANG HONG WOON , BLAKE JIM
IPC: A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02 , A61K
CPC classification number: C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
Abstract: Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R , R , R , R and R , W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Abstract translation: 公开了式（I）化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 8，R 9和R 10，W，X和Z是 如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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