公开(公告)号：RS61500B1

公开(公告)日：2021-03-31

申请号：RSP20210252

申请日：2013-03-01

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: C07D401/14 ,  A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596

公开(公告)号：PE06662015A1

公开(公告)日：2015-05-06

申请号：PE0013442014

申请日：2013-03-01

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: C07D401/14 ,  A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596

CPC classification number: C07D401/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/65586

Abstract: La invencion describe compuestos de formula l: o estereoisomeros, tautomeros, profarmacos o sales farmaceuticamente aceptables de los mismos, en la que R1, R2, R3, R4, X1, X2, Y1 y Y2 se definen en la presente solicitud. Estos compuestos son activos como inhibidores de serina/treonina cinasa, por lo que son utiles en el tratamiento de enfermedades hiperproliferativas e inflamatorias.

公开(公告)号：CR20140413A

公开(公告)日：2014-11-05

申请号：CR20140413

申请日：2014-09-08

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: C07D401/14 ,  A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Se proporcionan compuestos de Fórmula I o unestereoisómero, tautómero, profármaco o sal farmacéuticamenteaceptable de estos, que son útiles para 5 el tratamiento deenfermedades hiperproliferativas, inflamatorias y dolor.

公开(公告)号：HRP20180591T1

公开(公告)日：2018-05-18

申请号：HRP20180591

申请日：2018-04-13

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: C07D401/14 ,  A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596

公开(公告)号：PH12015501654B1

公开(公告)日：2017-04-10

申请号：PH12015501654

申请日：2015-07-24

Applicant: GENENTECH INC ,  ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：PH12015501653B1

公开(公告)日：2017-04-10

申请号：PH12015501653

申请日：2015-07-24

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：HK1206011A1

公开(公告)日：2015-12-31

申请号：HK15106441

申请日：2015-07-06

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： BLAKE JAMES F F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A A ,  MOHR PETER J J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  C07F20060101

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：CL2014002301A1

公开(公告)日：2015-05-08

申请号：CL2014002301

申请日：2014-08-29

Applicant: GENENTECH INC ,  ARRAY BIOPHARMA INC

Inventor： CHEN HUIFEN ,  BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REB LI ,  SCHWARZ JACOB ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：CA2882750A1

公开(公告)日：2014-03-06

申请号：CA2882750

申请日：2013-08-27

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： BLAKE JIM ,  CHEN HUIFEN ,  CHICARELLI MARK ,  GAUDINO JOHN ,  GAZZARD LEWIS ,  KINTZ SAM ,  MOHR PETE ,  ROBARGE KIRK ,  SCHWARZ JACOB ,  ZHOU AIHE

IPC: C07D401/14 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4725 ,  A61P35/00 ,  C07D217/22 ,  C07D401/12 ,  C07D471/04

Abstract: Compounds having the formula I are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating adenoma, bladder cancer, brain cancer, breast cancer, colon cancer, epidermal carcinoma, follicular carcinoma, cancer of the genitourinary tract, glioblastoma, Hodgkin's disease, head and neck cancers, hepatoma, keratoacanthoma, kidney cancer, large cell carcinoma, leukemias, lung adenocarcinoma, lung cancer, lymphoid disorders, melanoma and non-melanoma skin cancer, myelodysplasia syndrome, neuroblastoma, non-Hodgkins lymphoma, ovarian cancer, papillary carcinoma, pancreatic cancer, prostate cancer, rectal cancer, sarcoma, small cell carcinoma, testicular cancer, tetracarcinomas, thyroid cancer, and undifferentiated carcinoma.

公开(公告)号：SI3321262T1

公开(公告)日：2021-04-30

申请号：SI201331857

申请日：2013-03-01

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： BLAKE JAMES F ,  CHICARELLI MARK JOSEPH ,  GARREY RUSTAM FERDINAND ,  GAUDINO JOHN ,  GRINA JONAS ,  MORENO DAVID A ,  MOHR PETER J ,  REN LI ,  SCHWARZ JACOB ,  CHEN HUIFEN ,  ROBARGE KIRK ,  ZHOU AIHE

IPC: C07D401/00 ,  A61K31/00 ,  A61P29/00 ,  A61P35/00 ,  C07D405/00 ,  C07D409/00 ,  C07D413/00 ,  C07D417/00 ,  C07D471/00 ,  C07F9/00