公开(公告)号：WO2009126224A3

公开(公告)日：2011-07-14

申请号：PCT/US2009002089

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： MCNALLY CEARA J ,  BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  EWING CHARLES A ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  ROGERS ALEXIS L

IPC: G01N21/00

CPC classification number: G01F25/0084 ,  G01F22/00

Abstract: A system and related method for improved liquid delivery evaluation uses a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; a sample solution to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels with diluent solution. The sample solutions contain a dye, chosen so that multiple distinct detectable light absorbance spectral features can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device, and a small volume delivery device, are calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 用于改进液体递送评估的系统和相关方法使用含有一种或多种染料的溶液，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。 该系统包括：能够测量多个波长的光吸收的光度仪; 使用正在测试或校准其性能的液体输送系统分配的样品溶液; 和稀释液溶液。 样品溶液含有一种染料，其选择使得可以区分感兴趣的体积或稀释范围的多个不同的可检测光吸收光谱特征。 可以选择染料的浓度，使得用相同的样品溶液校准大体积输送装置和小体积输送装置，但是使用具有每单位光程长的高吸光度的不同光谱特征。

公开(公告)号：EP2069746A4

公开(公告)日：2011-06-22

申请号：EP07838269

申请日：2007-09-14

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  MCNALLY CEARA ,  ROGERS ALEX L

IPC: G01N1/10

CPC classification number: G01N21/31 ,  Y10T436/25625 ,  Y10T436/2575

公开(公告)号：EP2269025A4

公开(公告)日：2014-05-28

申请号：EP09729428

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： MCNALLY CEARA J ,  BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  EWING CHARLES A ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  ROGERS ALEXIS L

IPC: G01F22/00 ,  G01F25/00

CPC classification number: G01F25/0084 ,  G01F22/00

公开(公告)号：WO2008033521A2

公开(公告)日：2008-03-20

申请号：PCT/US2007020036

申请日：2007-09-14

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  MCNALLY CEARA ,  ROGERS ALEX L

IPC: G01N21/75

CPC classification number: G01N21/31 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.

Abstract translation: 本发明提供了确定稀释溶液的影响的方法，其中稀释可以用于各种目的中的任何一种。 在一个实施例中，该方法能够实现与弯液面形状无关的精确的体积分配计算。 在另一个实施方案中，该方法能够准确地确定洗板效率。 在另一个实施方案中，该方法能够在多个稀释步骤中精确测定稀释比。 所描述的方法可以使用布置成执行步骤的一个或多个系统来执行。 本发明的试剂盒包括用于执行所述方法和任选的一种或多种适于进行光度测量的溶液的步骤的说明书。

公开(公告)号：WO2007078513A2

公开(公告)日：2007-07-12

申请号：PCT/US2006046287

申请日：2006-12-05

Applicant: ARTEL INC

Inventor： ALBERT KEITH J

IPC: G01N31/00 ,  G06F19/00

CPC classification number: G01N35/1016 ,  G01F25/0092 ,  G01N1/38 ,  G01N21/25 ,  Y10T436/10 ,  Y10T436/25 ,  Y10T436/25625

Abstract: A method for precisely and accurately determining the volume of a test liquid aliquot which can be used to calibrate a liquid delivery device. The method is particularly useful for determining the volume of an aliquot of a test liquid which is complex or non-aqueous, or is both complex and non-aqueous. The test-stock mixture contains at least the test liquid and a stock solution including a first dye, the first dye having absorbance characteristics which are measurably distinguishable from the absorbance characteristics of a second dye. The test-stock mixture is mixed with a diluent including the second dye to form a sample solution to be used to measure absorbances of the first dye and the second dye. The volume of the test-stock mixture aliquot is calculated by using a formula based on the Beer-Lambert law which incorporates the measured absorbance values and a dilution characteristic of the test-stock mixture. The test liquid and the stock solution are combined gravimetrically in a controlled ratio so that the flow characteristics of the test-stock mixture correspond to the flow characteristics of the test liquid and without affecting the ability to distinguish the absorbance characteristics between the first dye and the second dye.

Abstract translation: 用于精确和准确地确定可用于校准液体输送装置的测试液体等分试样的体积的方法。 该方法特别可用于测定复合物或非水性的测试液体的等分试样的体积，或者是复合的和非水性的。 试料混合物至少包含测试液体和包含第一染料的原液，所述第一染料具有与第二染料的吸光度特性可测量的吸光度特性。 将试料混合物与包括第二染料的稀释剂混合以形成用于测量第一染料和第二染料的吸光度的样品溶液。 通过使用基于Beer-Lambert定律的公式计算测试样品混合物等分试样的体积，其中包含测量的吸光度值和测试样品混合物的稀释特性。 测试液体和储备溶液以受控比例重量分数组合，使得测试液体的流动特性对应于测试液体的流动特性，并且不影响区分第一染料和 第二染料。