公开(公告)号：JP2014197014A

公开(公告)日：2014-10-16

申请号：JP2014119206

申请日：2014-06-10

Applicant: アルテル、インコーポレイテッド ,  Artel Inc

Inventor： MCNALLY CEARA J ,  BRADSHAW JOHN THOMAS ,  RICHARD H CURTIS ,  EWING CHARLES A ,  KEITH J ALBERT ,  TANYA R KNAIDE ,  ROGERS ALEXIS L

IPC: G01N1/10

CPC classification number: G01F25/0084 ,  G01F22/00

Abstract: 【課題】関心のある体積及び希釈度範囲に対して過大な数のサンプル溶液の使用を必要としない方法を提供する。【解決手段】容器内のサンプル溶液の体積、又は、サンプル溶液の1もしくは複数の容器内での希釈剤による希釈度を判定する方法であって、サンプル溶液を希釈剤と混合し、複数の異なる検出可能な吸光度スペクトル特性を検出できる1又は複数の波長にてサンプル溶液と希釈剤との混合物の吸光度を測定し、この吸光度測定情報に基づいて、容器に加えられたサンプル溶液の体積及び/又は希釈剤によるサンプル溶液の希釈度を判定する方法であって、サンプル溶液及び希釈剤のいずれか又は両方が、その単一体積中に、ある範囲の体積及び/又はある範囲の希釈度を通じて、混合物中にて複数の異なる検出可能な吸光度スペクトル特性を生成するように選択された1又は複数の染料を含む。【選択図】なし

Abstract translation: 要解决的问题：提供不需要使用过量数量的样品溶液用于感兴趣的体积或稀释度范围的方法。解决方案：在用于测定容器或样品溶液中的样品溶液的体积的方法中， 将样品溶液与一个或多个容器中的稀释剂，样品溶液和稀释剂的稀释度混合，并且在一个或多个波长处测量样品溶液和稀释剂的混合物的吸光度，允许检测多种不同的 基于吸光度测量信息确定可检测的吸光度光谱特征，并且添加到容器中的样品溶液的体积和/或稀释剂的样品溶液的稀释度。 样品溶液和稀释剂中的一种或两种以单位体积计含有选择一种或多种染料，使得在体积和/或稀释范围内在混合物中产生多种不同的可检测光吸收光谱特征 度。

公开(公告)号：DE05711694T1

公开(公告)日：2007-02-22

申请号：DE05711694

申请日：2005-01-21

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H

IPC: G01J1/10 ,  G01J3/42 ,  G01N21/27 ,  G01N21/31

Abstract: An apparatus and related method for optical calibration of spectrophotometers is described. The apparatus is a calibration plate including one or more cuvettes filled with solutions of interest. The cuvettes are sealed to prevent evaporation. The cuvettes also possess a compressible component to allow for expansion of the solution and a bubble control apparatus to ensure that the compressible component does not intersect the beam path. A piece of neutral density glass is optionally included in the apparatus to track optical changes of the solutions over time.

公开(公告)号：WO2005074492A3

公开(公告)日：2006-03-23

申请号：PCT/US2005001769

申请日：2005-01-21

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H

IPC: G01J1/10 ,  G01J3/42 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/274 ,  G01N21/278 ,  G01N21/31 ,  G01N2021/054 ,  G01N2201/127 ,  G01N2201/1285 ,  G01N2201/1286

Abstract: An apparatus and related method for optical calibration of spectrophotometers is described. The apparatus is a calibration plate including one or more cuvettes filled with solutions of interest. The cuvettes are sealed to prevent evaporation. The cuvettes also possess a compressible component to allow for expansion of the solution and a bubble control apparatus to ensure that the compressible component does not intersect the beam path. A piece of neutral density glass is optionally included in the apparatus to track optical changes of the solutions over time.

Abstract translation: 描述了用于分光光度计的光学校准的装置和相关方法。 该装置是包括一个或多个充满感兴趣的溶液的比色杯的校准板。 试管被密封以防止蒸发。 试管还具有允许溶液膨胀的可压缩部件和气泡控制装置，以确保可压缩部件不与光束路径相交。 装置中可选地包括一片中性密度玻璃，以跟踪溶液随时间的光学变化。

公开(公告)号：WO2009126225A8

公开(公告)日：2010-01-28

申请号：PCT/US2009002096

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA ,  EWING CHARLES A ,  BRADSHAW JOHN THOMAS

IPC: B05B5/16 ,  B05B5/00 ,  F04B19/00

CPC classification number: G01N21/00 ,  B01L3/0234 ,  B01L2200/14 ,  B01L2200/148 ,  G01F25/0092

Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 描述了使用含有一种或多种染料的溶液改进液体递送评价的系统和相关方法，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。 该系统包括：能够测量多个波长的光吸收的光度仪; 使用其性能正在测试或校准的液体输送系统来分配的一种或多种样品溶液; 和任选地预先填充或由使用者填充的容器用稀释剂溶液。 样品溶液含有一种或多种染料，其选择使得可以区分感兴趣的体积或稀释范围的多种不同的可检测光吸收光谱特征，例如溶液的峰和/或谷和/或平台。 可以选择染料的浓度，使得使用溶液中的光谱特征来校准大体积输送装置，每单位通路长度具有低吸光度，而小体积输送装置用相同的样品溶液校准，但使用不同的光谱 特征具有每单位光程长的高吸光度。

公开(公告)号：WO2009126225A3

公开(公告)日：2009-12-17

申请号：PCT/US2009002096

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA ,  EWING CHARLES A ,  BRADSHAW JOHN THOMAS

IPC: B05B5/16 ,  B05B5/00 ,  F04B19/00

CPC classification number: G01N21/00 ,  B01L3/0234 ,  B01L2200/14 ,  B01L2200/148 ,  G01F25/0092

Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 描述了使用含有一种或多种染料的溶液改进液体递送评估的系统和相关方法，使得该溶液表现出多个不同的可检测光吸收光谱特征用于在扩展体积或稀释范围上校准或测试。 该系统包括：能够测量多个波长处的光吸收率的光度测量仪器; 使用其性能正在测试或校准的液体输送系统分配的一种或多种样品溶液; 以及可选地预先填充或由使用者填充稀释剂溶液的容器。 样品溶液含有一种或多种染料，所选择的染料可以针对感兴趣的体积或稀释范围区分溶液的多个不同的可检测光吸收光谱特征，例如峰和/或谷和/或平台。 可以选择染料的浓度，以便使用溶液中的光谱特征来校准大体积递送装置，其中每单位光程长度具有低吸光度，而小体积递送装置用相同的样品溶液校准，但使用不同的光谱 具有每单位光程长度的高吸光度。

公开(公告)号：WO2009126224A3

公开(公告)日：2011-07-14

申请号：PCT/US2009002089

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： MCNALLY CEARA J ,  BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  EWING CHARLES A ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  ROGERS ALEXIS L

IPC: G01N21/00

CPC classification number: G01F25/0084 ,  G01F22/00

Abstract: A system and related method for improved liquid delivery evaluation uses a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; a sample solution to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels with diluent solution. The sample solutions contain a dye, chosen so that multiple distinct detectable light absorbance spectral features can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device, and a small volume delivery device, are calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 用于改进液体递送评估的系统和相关方法使用含有一种或多种染料的溶液，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。 该系统包括：能够测量多个波长的光吸收的光度仪; 使用正在测试或校准其性能的液体输送系统分配的样品溶液; 和稀释液溶液。 样品溶液含有一种染料，其选择使得可以区分感兴趣的体积或稀释范围的多个不同的可检测光吸收光谱特征。 可以选择染料的浓度，使得用相同的样品溶液校准大体积输送装置和小体积输送装置，但是使用具有每单位光程长的高吸光度的不同光谱特征。

公开(公告)号：WO2008033521A2

公开(公告)日：2008-03-20

申请号：PCT/US2007020036

申请日：2007-09-14

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  MCNALLY CEARA ,  ROGERS ALEX L

IPC: G01N21/75

CPC classification number: G01N21/31 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.

Abstract translation: 本发明提供了确定稀释溶液的影响的方法，其中稀释可以用于各种目的中的任何一种。 在一个实施例中，该方法能够实现与弯液面形状无关的精确的体积分配计算。 在另一个实施方案中，该方法能够准确地确定洗板效率。 在另一个实施方案中，该方法能够在多个稀释步骤中精确测定稀释比。 所描述的方法可以使用布置成执行步骤的一个或多个系统来执行。 本发明的试剂盒包括用于执行所述方法和任选的一种或多种适于进行光度测量的溶液的步骤的说明书。

公开(公告)号：EP2269025A4

公开(公告)日：2014-05-28

申请号：EP09729428

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： MCNALLY CEARA J ,  BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  EWING CHARLES A ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  ROGERS ALEXIS L

IPC: G01F22/00 ,  G01F25/00

CPC classification number: G01F25/0084 ,  G01F22/00

公开(公告)号：EP2069746A4

公开(公告)日：2011-06-22

申请号：EP07838269

申请日：2007-09-14

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  MCNALLY CEARA ,  ROGERS ALEX L

IPC: G01N1/10

CPC classification number: G01N21/31 ,  Y10T436/25625 ,  Y10T436/2575

公开(公告)号：EP1709404A4

公开(公告)日：2009-09-09

申请号：EP05711694

申请日：2005-01-21

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H

IPC: G01J1/10 ,  G01J3/42 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/274 ,  G01N21/278 ,  G01N21/31 ,  G01N2021/054 ,  G01N2201/127 ,  G01N2201/1285 ,  G01N2201/1286

Abstract: An apparatus and related method for optical calibration of spectrophotometers is described. The apparatus is a calibration plate including one or more cuvettes filled with solutions of interest. The cuvettes are sealed to prevent evaporation. The cuvettes also possess a compressible component to allow for expansion of the solution and a bubble control apparatus to ensure that the compressible component does not intersect the beam path. A piece of neutral density glass is optionally included in the apparatus to track optical changes of the solutions over time.