公开(公告)号：US09404072B2

公开(公告)日：2016-08-02

申请号：US14709932

申请日：2015-05-12

Applicant: ASL Analytical, Inc.

Inventor： Edwin John Koerperick ,  Jonathon Todd Olesberg ,  Christine Esther Evans ,  Mark Allen Arnold ,  Gary Wray Small

IPC: G02B6/00 ,  C12M1/00 ,  G01N21/75 ,  C12M1/34 ,  G01N21/17 ,  G01N21/01 ,  B01L9/00 ,  C12Q1/02 ,  G01N15/14 ,  G01N21/359 ,  G01N15/06 ,  G01N21/03 ,  G01N15/00

CPC classification number: C12M1/00 ,  B01L9/00 ,  C12M1/34 ,  C12M23/28 ,  C12M41/00 ,  C12M41/46 ,  C12Q1/02 ,  G01N15/06 ,  G01N15/1456 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/17 ,  G01N21/359 ,  G01N21/75 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2021/0307 ,  G01N2021/0321 ,  G01N2021/0378

Abstract: An optical sampling apparatus for disposable flexible bioprocessing vessels includes features for optical interrogation of the vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the vessels during bioprocesses.

Abstract translation: 用于一次性柔性生物处理容器的光学取样装置包括通过透射或透射光谱对容器内容物进行光学询问的特征。 这种光学询问允许在生物处理期间确定容器内所含流体中物质的数量和参数。

公开(公告)号：US09540701B2

公开(公告)日：2017-01-10

申请号：US14631917

申请日：2015-02-26

Applicant: ASL Analytical, Inc.

Inventor： Jonathon Todd Olesberg ,  Mark Allen Arnold ,  Gary Wray Small ,  Edwin John Koerperick ,  Christine Esther Evans

IPC: C12Q3/00 ,  G01N21/359 ,  G01N21/39 ,  G01N21/3577 ,  G01N21/31 ,  G01N21/51 ,  G01N21/64 ,  G01N21/65

CPC classification number: C12Q3/00 ,  G01N21/314 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/51 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/399 ,  G01N2201/067 ,  G01N2201/0846

Abstract: A system and method for continuous, real-time process monitoring and control by means of near-infrared (NIR) spectroscopy provides analysis of static or flowing fluid streams which may range from clear to highly optically dense, including fluids primarily of aqueous composition. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness in laboratory and industrial settings.

Abstract translation: 通过近红外（NIR）光谱进行连续，实时过程监测和控制的系统和方法提供了静态或流动的流体流的分析，其可以从清楚到高度光密度，包括主要是含水组成的流体。 NIR源通过波长选择器以选择一个或多个光谱段，其在流体采样接口处通过流体流并在传感器处接收。 波长参考材料位于用于校准的光路中。 可以对包含在其中的流体和悬浮固体或细胞的多个特征或参数进行定量。 光学系统的全固态实现确保了实验室和工业环境中的高稳定性。

公开(公告)号：US09360422B2

公开(公告)日：2016-06-07

申请号：US14709955

申请日：2015-05-12

Applicant: ASL Analytical, Inc.

Inventor： Edwin John Koerperick ,  Jonathon Todd Olesberg ,  Christine Esther Evans ,  Mark Allen Arnold ,  Gary Wray Small

IPC: G01J5/02 ,  G01N21/359 ,  G01N21/75 ,  C12M1/34 ,  G01N21/17 ,  G01N21/01 ,  B01L9/00 ,  C12Q1/02 ,  G01N15/14 ,  C12M1/00 ,  G01N15/00

CPC classification number: C12M1/00 ,  B01L9/00 ,  C12M1/34 ,  C12M23/28 ,  C12M41/00 ,  C12M41/46 ,  C12Q1/02 ,  G01N15/06 ,  G01N15/1456 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/17 ,  G01N21/359 ,  G01N21/75 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2021/0307 ,  G01N2021/0321 ,  G01N2021/0378

Abstract: An optical probe with associated disposable polymer sheath for near-infrared optical interrogation of fluids within bioprocessing vessels by means of transmission or transflection spectroscopy provides for the determination of quantities and parameters of substances in fluids contained within bioprocessing vessels. Associated methods for use of the optical probe and associated sheath to determine quantities of substances in fluids and parameters of fluids during bioprocesses are provided.

Abstract translation: 具有相关联的一次性聚合物护套的光学探针用于通过透射或透射光谱对生物处理容器内的流体进行近红外光学询问，从而确定生物处理容器内所含流体中物质的数量和参数。 提供了在生物处理过程中使用光学探头和相关护套确定流体中物质数量和流体参数的相关方法。

公开(公告)号：US20150247794A1

公开(公告)日：2015-09-03

申请号：US14631917

申请日：2015-02-26

Applicant: ASL Analytical, Inc.

Inventor： Jonathon Todd Olesberg ,  Mark Allen Arnold ,  Gary Wray Small ,  Edwin John Koerperick ,  Christine Esther Evans

IPC: G01N21/359 ,  G01N21/3577

CPC classification number: C12Q3/00 ,  G01N21/314 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/51 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/399 ,  G01N2201/067 ,  G01N2201/0846

Abstract: A system and method for continuous, real-time process monitoring and control by means of near-infrared (NIR) spectroscopy provides analysis of static or flowing fluid streams which may range from clear to highly optically dense, including fluids primarily of aqueous composition. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness in laboratory and industrial settings.

Abstract translation: 通过近红外（NIR）光谱进行连续，实时过程监测和控制的系统和方法提供了静态或流动的流体流的分析，其可以从清楚到高度光密度，包括主要是含水组成的流体。 NIR源通过波长选择器以选择一个或多个光谱段，其在流体采样接口处通过流体流并在传感器处接收。 波长参考材料位于用于校准的光路中。 可以对包含在其中的流体和悬浮固体或细胞的多个特征或参数进行定量。 光学系统的全固态实现确保了实验室和工业环境中的高稳定性。

公开(公告)号：US20150330903A1

公开(公告)日：2015-11-19

申请号：US14709932

申请日：2015-05-12

Applicant: ASL Analytical, Inc.

Inventor： Edwin John Koerperick ,  Jonathon Todd Olesberg ,  Christine Esther Evans ,  Mark Allen Arnold ,  Gary Wray Small

IPC: G01N21/75 ,  G01N21/01 ,  G01N21/17 ,  C12M1/34 ,  C12M1/00

CPC classification number: C12M1/00 ,  B01L9/00 ,  C12M1/34 ,  C12M23/28 ,  C12M41/00 ,  C12M41/46 ,  C12Q1/02 ,  G01N15/06 ,  G01N15/1456 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/17 ,  G01N21/359 ,  G01N21/75 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2021/0307 ,  G01N2021/0321 ,  G01N2021/0378

Abstract: An optical sampling apparatus for disposable flexible bioprocessing vessels includes features for optical interrogation of the vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the vessels during bioprocesses.

Abstract translation: 用于一次性柔性生物处理容器的光学取样装置包括通过透射或透射光谱对容器内容物进行光学询问的特征。 这种光学询问允许在生物处理期间确定容器内所含流体中物质的数量和参数。

公开(公告)号：US20150330894A1

公开(公告)日：2015-11-19

申请号：US14709955

申请日：2015-05-12

Applicant: ASL Analytical, Inc.

Inventor： Edwin John Koerperick ,  Jonathon Todd Olesberg ,  Christine Esther Evans ,  Mark Allen Arnold ,  Gary Wray Small

IPC: G01N21/359 ,  B01L9/00 ,  C12Q1/02

CPC classification number: C12M1/00 ,  B01L9/00 ,  C12M1/34 ,  C12M23/28 ,  C12M41/00 ,  C12M41/46 ,  C12Q1/02 ,  G01N15/06 ,  G01N15/1456 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/17 ,  G01N21/359 ,  G01N21/75 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2021/0307 ,  G01N2021/0321 ,  G01N2021/0378

Abstract: An optical probe with associated disposable polymer sheath for near-infrared optical interrogation of fluids within bioprocessing vessels by means of transmission or transflection spectroscopy provides for the determination of quantities and parameters of substances in fluids contained within bioprocessing vessels. Associated methods for use of the optical probe and associated sheath to determine quantities of substances in fluids and parameters of fluids during bioprocesses are provided.

Abstract translation: 具有相关联的一次性聚合物护套的光学探针用于通过透射或透射光谱对生物处理容器内的流体进行近红外光学询问，从而确定生物处理容器内所含流体中物质的数量和参数。 提供了在生物处理过程中使用光学探头和相关护套确定流体中物质数量和流体参数的相关方法。

公开(公告)号：US20150329892A1

公开(公告)日：2015-11-19

申请号：US14709685

申请日：2015-05-12

Applicant: ASL Analytical, Inc.

Inventor： Edwin John Koerperick ,  Jonathon Todd Olesberg ,  Christine Esther Evans ,  Mark Allen Arnold ,  Gary Wray Small

IPC: C12Q1/02 ,  C12M1/34 ,  C12M1/00 ,  G01N15/14 ,  G01N21/359

CPC classification number: C12M1/00 ,  B01L9/00 ,  C12M1/34 ,  C12M23/28 ,  C12M41/00 ,  C12M41/46 ,  C12Q1/02 ,  G01N15/06 ,  G01N15/1456 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/17 ,  G01N21/359 ,  G01N21/75 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2021/0307 ,  G01N2021/0321 ,  G01N2021/0378

Abstract: An optical sampling apparatus for miniature-scale bioprocessing vessels includes features for optical interrogation of the bioprocessing vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the bioprocessing vessels during bioprocesses. Multiple such bioprocessing vessels with the optical interrogation features may be mounted in a receiver for conducting multiple bioprocesses simultaneously. A translatable probe may be used to interact with each of the bioprocessing vessels in the receiver.

Abstract translation: 用于微型尺寸生物处理容器的光学取样装置包括通过透射或透射光谱对生物处理容器内容物进行光学询问的特征。 这种光学询问允许在生物处理过程中确定生物处理容器内所含流体中物质的数量和参数。 具有光学询问特征的多个这样的生物处理容器可以安装在用于同时进行多个生物处理的接收器中。 可以使用可翻译探针与接收器中的每个生物处理容器相互作用。