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公开(公告)号：WO2014189849A1
公开(公告)日：2014-11-27
申请号：PCT/US2014/038637
申请日：2014-05-19
Applicant: AVEDRO, INC.
Inventor： KAMAEV, Pavel , FRIEDMAN, Marc , SHERR, Evan , MULLER, David
IPC: A61K31/495 , A61K31/525 , A61K33/26 , A61K33/40 , A61K41/00 , A61P27/02
CPC classification number: A61K33/26 , A61K31/121 , A61K31/122 , A61K31/47 , A61K31/498 , A61K31/519 , A61K31/525 , A61K33/40 , A61K41/00 , A61K45/06 , A61N5/062 , A61K2300/00
Abstract: Various agents and additives for cross-linking treatments are identified in disclosed studies. The characteristics of the various agents and additives may be advantageously employed in formulations applied in cross-linking treatments of the eye. In some embodiments, riboflavin is combined with Iron(II) to enhance the cross-linking activity generated by the riboflavin. In other embodiments, cross-linking treatments employ an Iron(II) solution in combination with a hydrogen peroxide pre-soak. In yet other embodiments, 2,3-butanedione is employed to increase the efficacy of corneal cross-linking with a photosensitizer, such as riboflavin. In further embodiments, folic acid is employed in combination with a photosensitizer, such as riboflavin, to enhance cross-linking activity. In yet further embodiments, 2,3-butanedione, folic acid, a quinoxaline, a quinoline, dibucaine, Methotrexate, menadione, or a derivative thereof is applied as a cross-linking agent.
Abstract translation: 在公开的研究中鉴定了用于交联处理的各种试剂和添加剂。 各种试剂和添加剂的特征可有利地用于在眼睛的交联处理中应用的制剂中。 在一些实施方案中，将核黄素与铁（II）结合以增强由核黄素产生的交联活性。 在其它实施方案中，交联处理使用与过氧化氢预浸泡组合的铁（II）溶液。 在其它实施方案中，2,3-丁二酮用于增加与光敏剂如核黄素的角膜交联的功效。 在另外的实施方案中，叶酸与光敏剂如核黄素组合使用以增强交联活性。 在另外的实施方案中，应用2,3-丁二酮，叶酸，喹喔啉，喹啉，地布卡因，甲氨蝶呤，甲萘醌或其衍生物作为交联剂。
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公开(公告)号：WO2016069628A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/057628
申请日：2015-10-27
Applicant: AVEDRO, INC.
Inventor： FRIEDMAN, Marc , KAMAEV, Pavel , SMIRNOV, Mikhail
CPC classification number: A61F9/0079 , A61F9/007 , A61F9/008 , A61F9/00825 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893
Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.
Abstract translation: 用于角膜治疗的系统包括激活在用交联剂处理的角膜的至少一个选定区域中的交联的光源。 光源根据一组参数将光活化光传送到角膜的至少一个选定区域。 该系统包括控制器，其接收与交联代理和该组参数相关的输入。 控制器包括计算机可读存储介质，其存储：（A）用于确定由涉及至少包括过氧化物，超氧化物和羟基自由基的ROS的反应产生的交联的程序指令，和（B）用于确定反应的交联的程序指令 涉及氧气。 控制器执行程序指令以在角膜的至少一个选定区域中输出计算量的交联。 响应于计算的交联量，光源调整该组参数中的至少一个值。
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3.发明申请SYSTEMS AND METHODS FOR PHOTOACTIVATING A PHOTOSENSITIZER APPLIED TO AN EYE 审中-公开用于摄影适用于眼睛的光敏剂的系统和方法
公开(公告)号：WO2016172695A1
公开(公告)日：2016-10-27
申请号：PCT/US2016/029187
申请日：2016-04-25
Applicant: AVEDRO, INC.
Inventor： FRIEDMAN, Marc , SMIRNOV, Mikhail , KAMAEV, Pavel
CPC classification number: A61N5/0624 , A61F9/029 , A61M2202/0208 , A61M2205/3368 , A61M2205/36 , A61M2205/52 , A61M2210/0612 , A61N5/062 , A61N2005/0626 , A61N2005/0648 , A61N2005/0661
Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.
Abstract translation: 抗微生物治疗系统包括可佩戴的光活化装置。 佩戴式光激活装置包括被配置为定位在受试者的头部上的主体的主体的一个或多个眼睛上的主体。 身体包括允许一只或多只眼睛透过身体观察的一个或多个窗户或开口。 身体包括耦合到身体并被配置为根据照明参数将光活化到一个或多个眼睛的一个或多个光活化光源。 光照参数确定光活化光的剂量，其根据光化学动力学反应激活施加到一个或多个眼睛上的光敏剂，并产生在一个或多个眼睛中提供抗微生物作用的活性氧， 在一个或多个眼睛中产生生物力学变化的连接活动。
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4.发明申请
公开(公告)号：WO2016090016A1
公开(公告)日：2016-06-09
申请号：PCT/US2015/063466
申请日：2015-12-02
Applicant: AVEDRO, INC.
Inventor： KAMAEV, Pavel , FRIEDMAN, Marc , SHERR, Evan , PETERSON, Sarah, M. , MULLER, David
IPC: A61K31/525 , A61K33/26 , A61K41/00 , A61P27/02
CPC classification number: A61K41/00 , A61F9/0079 , A61K31/525 , A61K33/26 , A61K47/02 , A61K47/12 , A61L31/14 , A61L2430/16 , A61N5/062 , A61P27/02 , A61K2300/00
Abstract: Systems, methods, and compositions generate cross-linking activity for treatment of eye disorders. Various agents, additives, buffers, etc., may be employed in formulations with a cross-linking agent to enhance treatment. For example, a composition for applying treatment to a cornea of an eye includes a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light. The composition also includes an iron additive and citrate buffer. In some cases, the cross-linking agent may include riboflavin. In other cases, the iron additive may include FeSO 4 . In further cases, the iron additive may be dissolved in the citrate buffer.
Abstract translation: 系统，方法和组合物产生用于治疗眼睛疾病的交联活性。 可以在具有交联剂的制剂中使用各种试剂，添加剂，缓冲剂等以增强处理。 例如，用于对眼睛的角膜进行治疗的组合物包括响应于曝光于光激活光而在角膜中产生交联活性的交联剂。 该组合物还包括铁添加剂和柠檬酸盐缓冲液。 在一些情况下，交联剂可以包括核黄素。 在其他情况下，铁添加剂可以包括FeSO 4。 在另外的情况下，铁添加剂可以溶解在柠檬酸盐缓冲液中。
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公开(公告)号：WO2011116306A3
公开(公告)日：2011-09-22
申请号：PCT/US2011/029033
申请日：2011-03-18
Applicant: AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Ronald , KAMAEV, Pavel , PERTAUB, Radha
Inventor： MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Ronald , KAMAEV, Pavel , PERTAUB, Radha
Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
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Patent Agency Ranking
公开(公告)号：WO2017015471A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043359
申请日：2016-07-21
Applicant: AVEDRO, INC.
Inventor： KAMAEV, Pavel , FRIEDMAN, Marc
CPC classification number: A61K41/0057 , A61F9/0017 , A61F9/0079 , A61K9/0048 , A61K31/525 , A61K33/00 , A61K47/02 , A61N5/062 , A61N2005/0661
Abstract: A formulation for an eye treatment includes a photosensitizer and a permeability enhancing composition. The permeability enhancing composition includes one or more permeability enhancers. The permeability enhancing composition has a hydrophilic and lipophilic balance increases a permeability of an area of the eye for the photosensitizer. The hydrophilic and lipophilic balance can be characterized by a Hydrophile-Lipophile Balance (HLB) number. For example, the area of the eye may include a corneal epithelium, the photosensitizer may include riboflavin, and the permeability enhancing composition may have a corresponding HLB number between approximately 12.6 and approximately 14.6.
Abstract translation: 用于眼部治疗的制剂包括光敏剂和渗透性增强组合物。 渗透性提高组合物包括一种或多种渗透性增强剂。 渗透性提高组合物具有亲水和亲油平衡，增加了光敏剂的眼睛面积的渗透性。 亲水和亲油平衡可以通过亲水亲油平衡（HLB）数来表征。 例如，眼睛的面积可以包括角膜上皮，光敏剂可以包括核黄素，并且渗透性增强组合物可以具有约12.6至约14.6之间的相应HLB数。
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公开(公告)号：WO2016077747A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/060667
申请日：2015-11-13
Applicant: AVEDRO, INC.
Inventor： BUKSHTAB, Michael, A. , FRIEDMAN, Marc
CPC classification number: G02B21/0056 , A61B3/13 , A61B3/14 , A61B5/0068 , A61B5/0075 , G01B9/02044 , G01J3/00 , G02B17/006 , G02B21/0048
Abstract: An example system determines biomechanical properties of eye tissue. The system includes a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of the tissue. The incident light is reflected by the plurality of cross-sections of tissue as scattered light. The system includes a spectrometer to receive the scattered light and provide spectral information for the scattered light. The system includes processor(s) to determine a Brillouin frequency shift from the spectral information and to generate a three-dimensional profile of the corneal tissue according to the Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the tissue. The spectrometer includes a multipass optical device that generates an interference pattern from the scattered light. The interference pattern provides the spectral information for the scattered light. The spectrometer includes a camera to detect the interference pattern from the optical device.
Abstract translation: 示例系统确定眼组织的生物力学性质。 该系统包括配置成扫描穿过组织的多个横截面的入射光的共焦显微镜系统。 入射光被组织的多个横截面反射为散射光。 该系统包括用于接收散射光并提供散射光的光谱信息的光谱仪。 该系统包括从光谱信息确定布里渊频移并且根据布里渊频移产生角膜组织的三维轮廓的处理器。 三维轮廓提供组织的一个或多个生物力学性质的指示。 光谱仪包括从散射光产生干涉图案的多光学光学装置。 干涉图案为散射光提供光谱信息。 光谱仪包括用于检测来自光学装置的干涉图案的照相机。
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8.发明申请CONTROLLED CROSS-LINKING INITIATION AND CORNEAL TOPOGRAPHY FEEDBACK SYSTEMS FOR DIRECTING CROSS-LINKING 审中-公开控制交叉引导和导向交叉连接的角度反射系统
公开(公告)号：WO2012145159A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/032024
申请日：2012-04-03
Applicant: AVEDRO, INC. , MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Stephen , KAMAEV, Pavel , PERTAUB, Radha
Inventor： MULLER, David , MARSHALL, John , FRIEDMAN, Marc , BLINN, Stephen , SCHARF, Stephen , KAMAEV, Pavel , PERTAUB, Radha
CPC classification number: A61N5/062 , A61B2018/00619 , A61F9/0079 , A61F2009/00844 , A61F2009/00872 , A61F2009/00882
Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
Abstract translation: 用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。 提供反馈系统以获取测量并将反馈信息传递给控制器。 反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。 该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。 反馈系统的方面也可用于监测和诊断眼睛的特征。 还提供了根据反馈系统提供的信息激活交联的方法，以提高交联疗法的准确性和安全性。
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9.发明公开
公开(公告)号：EP3226871A1
公开(公告)日：2017-10-11
申请号：EP15864372.6
申请日：2015-12-02
Applicant: Avedro, INC.
Inventor： KAMAEV, Pavel , FRIEDMAN, Marc , SHERR, Evan , PETERSON, Sarah, M. , MULLER, David
IPC: A61K31/525 , A61K33/26 , A61K41/00 , A61P27/02
CPC classification number: A61K41/00 , A61F9/0079 , A61K31/525 , A61K33/26 , A61K47/02 , A61K47/12 , A61L31/14 , A61L2430/16 , A61N5/062 , A61P27/02 , A61K2300/00
Abstract: Systems, methods, and compositions generate cross-linking activity for treatment of eye disorders. Various agents, additives, buffers, etc., may be employed in formulations with a cross-linking agent to enhance treatment. For example, a composition for applying treatment to a cornea of an eye includes a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light. The composition also includes an iron additive and citrate buffer. In some cases, the cross-linking agent may include riboflavin. In other cases, the iron additive may include FeSO4. In further cases, the iron additive may be dissolved in the citrate buffer.
Abstract translation: 系统，方法和组合物产生用于治疗眼睛疾病的交联活性。 各种试剂，添加剂，缓冲剂等可以用于具有交联剂的制剂中以增强治疗。 例如，用于对眼睛角膜施加治疗的组合物包括交联剂，其响应于暴露于光活化光而在角膜中产生交联活性。 该组合物还包含铁添加剂和柠檬酸盐缓冲剂。 在一些情况下，交联剂可能包括核黄素。 在其他情况下，铁添加剂可以包括FeSO 4。在其他情况下，铁添加剂可以溶解在柠檬酸盐缓冲液中。
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10.发明公开SYSTEMS, METHODS, AND COMPOSITIONS FOR CROSS-LINKING 审中-公开VERNETZUNGSSYSTEME，-VERFAHREN UND-ZUSAMMENSETZUNGEN
公开(公告)号：EP2999471A1
公开(公告)日：2016-03-30
申请号：EP14800815.4
申请日：2014-05-19
Applicant: Avedro, INC.
Inventor： KAMAEV, Pavel , FRIEDMAN, Marc , SHERR, Evan , MULLER, David
IPC: A61K31/495 , A61K31/525 , A61K33/26 , A61K33/40 , A61K41/00 , A61P27/02
CPC classification number: A61K33/26 , A61K31/121 , A61K31/122 , A61K31/47 , A61K31/498 , A61K31/519 , A61K31/525 , A61K33/40 , A61K41/00 , A61K45/06 , A61N5/062 , A61K2300/00
Abstract: Various agents and additives for cross-linking treatments are identified in disclosed studies. The characteristics of the various agents and additives may be advantageously employed in formulations applied in cross-linking treatments of the eye. In some embodiments, riboflavin is combined with Iron(II) to enhance the cross-linking activity generated by the riboflavin. In other embodiments, cross-linking treatments employ an Iron(II) solution in combination with a hydrogen peroxide pre-soak. In yet other embodiments, 2,3-butanedione is employed to increase the efficacy of corneal cross-linking with a photosensitizer, such as riboflavin. In further embodiments, folic acid is employed in combination with a photosensitizer, such as riboflavin, to enhance cross-linking activity. In yet further embodiments, 2,3-butanedione, folic acid, a quinoxaline, a quinoline, dibucaine, Methotrexate, menadione, or a derivative thereof is applied as a cross-linking agent.
Abstract translation: 在公开的研究中鉴定了用于交联处理的各种试剂和添加剂。 各种试剂和添加剂的特征可有利地用于在眼睛的交联处理中应用的制剂中。 在一些实施方案中，将核黄素与铁（II）结合以增强由核黄素产生的交联活性。 在其它实施方案中，交联处理使用与过氧化氢预浸泡组合的铁（II）溶液。 在其它实施方案中，2,3-丁二酮用于增加与光敏剂如核黄素的角膜交联的功效。 在另外的实施方案中，叶酸与光敏剂如核黄素组合使用以增强交联活性。 在另外的实施方案中，应用2,3-丁二酮，叶酸，喹喔啉，喹啉，地布卡因，甲氨蝶呤，甲萘醌或其衍生物作为交联剂。
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