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公开(公告)号：DK0928291T3
公开(公告)日：2003-03-17
申请号：DK97935308
申请日：1997-08-04
Applicant: AVENTIS PHARMA INC
Inventor： WARSHAWSKY ALAN M , FLYNN GARY A , PATEL MEENA V , BEIGHT DOUGLAS W , BURKHART JOSEPH P , TSAY JIU-TSAIR , JANUSZ MICHAEL J , SHEN JIAN , DHARANIPRAGADA RAMALINGA M
IPC: A61K38/55 , A61K38/00 , A61P1/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K5/078 , A61K38/05
Abstract: The present invention relates to certain novel 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase. Pharmaceutical compositions containing said compounds as well as methods of treating various disease states responding to inhibition of matrix metalloproteinase are also claimed herein.
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公开(公告)号：HU221197B1
公开(公告)日：2002-08-28
申请号：HU9603312
申请日：1995-05-05
Applicant: AVENTIS PHARMA INC
Inventor： ANGELASTRO MICHAEL R , BURKHART JOSEPH P , GALLION STEVEN L , METZ WILLIAM AJR , PEET NORTON P
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公开(公告)号：HK1015797A1
公开(公告)日：1999-10-22
申请号：HK99100976
申请日：1999-03-09
Applicant: AVENTIS PHARMA INC
Inventor： MALIKAYL J ANTHONY , BURKHART JOSEPH P , BROERSMA ROBERT J , PEET NORTON P
IPC: A61K38/55 , A61K31/00 , A61K38/00 , A61P7/00 , A61P7/02 , C07K5/06 , C07K5/075 , C07K5/08 , C07K5/087 , C07K5/097 , C07K , A61K
Abstract: This invention relates to polyfluoroalkyl tryptophan tripeptides and to compositions containing them. The compounds are highly selective thrombin inhibitors which provide anticoagulant effects useful in the treatment of thrombin conditions and in preventing the coagulation of stored whole blood and blood products.
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公开(公告)号：ES2199992T3
公开(公告)日：2004-03-01
申请号：ES95918993
申请日：1995-05-05
Applicant: AVENTIS PHARMA INC
Inventor： METZ WILLIAM A JR , GALLION STEVEN L , BURKHART JOSEPH P , ANGELASTRO MICHAEL R , PEET NORTON P
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公开(公告)号：PT1150976E
公开(公告)日：2003-07-31
申请号：PT99962921
申请日：1999-11-30
Applicant: AVENTIS PHARMA INC
Inventor： JANUSZ MICHAEL J , FLYNN GARY A , WARSHAWSKY ALAN M , BURKHART JOSEPH P
IPC: C07D401/12 , A61K31/403 , A61K31/4035 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K38/00 , A61P1/02 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , C07D209/48 , C07D403/12 , C07K5/02 , C07K5/078 , A61K31/4015 , A61K31/4409 , A61K31/45 , B23K26/00 , C07D207/26
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Patent Agency Ranking
公开(公告)号：AT233259T
公开(公告)日：2003-03-15
申请号：AT99962921
申请日：1999-11-30
Applicant: AVENTIS PHARMA INC
Inventor： WARSHAWSKY ALAN , JANUSZ MICHAEL J , FLYNN GARY A , BURKHART JOSEPH P
IPC: C07D401/12 , A61K31/403 , A61K31/4035 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K38/00 , A61P1/02 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , C07D209/48 , C07D403/12 , C07K5/02 , C07K5/078 , A61K31/4015 , A61K31/4409 , A61K31/45 , C07D207/26
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公开(公告)号：AU6866101A
公开(公告)日：2002-01-08
申请号：AU6866101
申请日：2001-06-21
Applicant: AVENTIS PHARMA INC
Inventor： PEET NORTON P , WEINTRAUB PHILIP M , BURKHART JOSEPH P , GATES CYNTHIA A
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公开(公告)号：CA2358939A1
公开(公告)日：2000-07-13
申请号：CA2358939
申请日：1999-11-30
Applicant: AVENTIS PHARMA INC
Inventor： BURKHART JOSEPH P , FLYNN GARY A , JANUSZ MICHAEL J , WARSHAWSKY ALAN
IPC: C07D401/12 , A61K31/403 , A61K31/4035 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K38/00 , A61P1/02 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , C07D209/48 , C07D403/12 , C07K5/02 , C07K5/078 , A61K31/4015 , A61K31/4409 , A61K31/45 , C07D207/26
Abstract: The present invention provides novel thio-substituted amido lactam derivativ es of formula (1) useful in as inhibitors of matrix metallo-proteinases (MMPs).
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公开(公告)号：SI0928291T1
公开(公告)日：2003-06-30
申请号：SI9730468
申请日：1997-08-04
Applicant: AVENTIS PHARMA INC
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公开(公告)号：AU1926700A
公开(公告)日：2000-07-24
申请号：AU1926700
申请日：1999-11-30
Applicant: AVENTIS PHARMA INC
Inventor： WARSHAWSKY ALAN , JANUSZ MICHAEL J , FLYNN GARY A , BURKHART JOSEPH P
IPC: C07D401/12 , A61K31/403 , A61K31/4035 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K38/00 , A61P1/02 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , C07D209/48 , C07D403/12 , C07K5/02 , C07K5/078 , A61K31/4015 , A61K31/4409 , A61K31/45 , C07D207/26
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