公开(公告)号：AU2003225131A1

公开(公告)日：2003-11-10

申请号：AU2003225131

申请日：2003-04-23

Applicant: AVENTIS PHARMA INC

Inventor： JURCAK JOHN G ,  GROSS ALEXANDRE ,  WHITELEY BRIAN ,  MUSICK KWON YON ,  KLEIN JOSEPH T ,  MERRIMAN GREGORY H ,  WEINTRAUB PHILIP M ,  SABOL JEFFREY S ,  DHARANIPRAGADA RAMALINGA ,  HRIB NICHOLAS J

IPC: A61K31/40 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

公开(公告)号：AU6866101A

公开(公告)日：2002-01-08

申请号：AU6866101

申请日：2001-06-21

Applicant: AVENTIS PHARMA INC

Inventor： PEET NORTON P ,  WEINTRAUB PHILIP M ,  BURKHART JOSEPH P ,  GATES CYNTHIA A

IPC: A61P5/28 ,  C07J13/00 ,  A61K31/57

公开(公告)号：AU2004270187A1

公开(公告)日：2005-03-17

申请号：AU2004270187

申请日：2004-09-01

Applicant: AVENTIS PHARMA INC

Inventor： MUSICK KWON YON ,  EASTWOOD PAUL R ,  KOEHL JACK R ,  MOORCROFT NEIL ,  MEHDI SHUJAATH ,  WEINTRAUB PHILIP M ,  JIANG JOHN Z

IPC: A61K31/404 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P9/10 ,  C07D209/40 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07D487/08

Abstract: The present invention relates to a series of substituted aza-indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

公开(公告)号：DE60313769T2

公开(公告)日：2008-03-06

申请号：DE60313769

申请日：2003-04-23

Applicant: AVENTIS PHARMA INC

Inventor： MERRIMAN GREGORY H ,  WEINTRAUB PHILIP M ,  SABOL JEFFREY S ,  DHARANIPRAGADA RAMALINGA ,  HRIB NICHOLAS J ,  JURCAK JOHN G ,  GROSS ALEXANDRE ,  WHITELEY BRIAN ,  MUSICK KWON YON ,  KLEIN JOSEPH T

IPC: C07D209/42 ,  A61K31/40 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

公开(公告)号：DE60313769D1

公开(公告)日：2007-06-21

申请号：DE60313769

申请日：2003-04-23

Applicant: AVENTIS PHARMA INC

Inventor： MERRIMAN GREGORY H ,  WEINTRAUB PHILIP M ,  SABOL JEFFREY S ,  DHARANIPRAGADA RAMALINGA ,  HRIB NICHOLAS J ,  JURCAK JOHN G ,  GROSS ALEXANDRE ,  WHITELEY BRIAN ,  MUSICK KWON YON ,  KLEIN JOSEPH T

IPC: C07D209/42 ,  A61K31/40 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14

公开(公告)号：MXPA06011223A

公开(公告)日：2007-01-16

申请号：MXPA06011223

申请日：2005-03-29

Applicant: AVENTIS PHARMA INC

Inventor： WEINTRAUB PHILIP M ,  PEUKERT STEFAN ,  MEHDI SHUJAATH ,  MUSICK KWON YON ,  JIANG JOHN Z ,  MOORCROFT NEIL ,  EASTWOOD PAUL R ,  STEFANY DAVID W ,  LIM SUNGTAEK ,  RUTTEN HARTMUT ,  SCHWAHN UWE

IPC: A61K31/44 ,  A61P9/00 ,  A61P9/10 ,  A61P19/02 ,  A61P25/28 ,  A61P29/00 ,  C07D213/62 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

Abstract: La presente invencion se refiere a una serie de derivados de piridona 2,3,5-sustituidos de formula I: (Ver formula (I)) en la que R, R1, R2, R3 y R4 son como se definieron en la presente. Esta invencion tambien se refiere a metodos para fabricar estos compuestos. Los compuestos de esta invencion son inhibidores de la poli(adenosina 5'-difosfato ribosa)-polimerasa (PARP) y, por tanto, son utiles como agentes farmaceuticos, en especial en el tratamiento y/o prevencion de una diversidad de enfermedades, incluyendo enfermedades asociadas con el sistema nervioso central, y trastornos cardiovasculares.

公开(公告)号：AU2005230901A1

公开(公告)日：2005-10-20

申请号：AU2005230901

申请日：2005-03-29

Applicant: AVENTIS PHARMA INC

Inventor： RUTTEN HARTMUT ,  LIM SUNGTAEK ,  MOORCROFT NEIL ,  STEFANY DAVID W ,  SCHWAHN UWE ,  PEUKERT STEFAN ,  EASTWOOD PAUL R ,  MUSICK KWON YON ,  MEHDI SHUJAATH ,  JIANG JOHN Z ,  WEINTRAUB PHILIP M

IPC: A61K31/44 ,  C07D213/62 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

公开(公告)号：CA2537097A1

公开(公告)日：2005-03-17

申请号：CA2537097

申请日：2004-09-01

Applicant: AVENTIS PHARMA INC

Inventor： MUSICK KWON YON ,  JIANG JOHN Z ,  WEINTRAUB PHILIP M ,  EASTWOOD PAUL R ,  KOEHL JACK R ,  MEHDI SHUJAATH ,  MOORCROFT NEIL

IPC: A61K31/404 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P9/10 ,  C07D209/40 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07D487/08

Abstract: The present invention relates to a series of substituted indole derivatives of the formula I as described herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5~-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or preventi on of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

公开(公告)号：UY28833A1

公开(公告)日：2005-10-31

申请号：UY28833

申请日：2005-03-30

Applicant: AVENTIS PHARMA INC

Inventor： WEINTRAUB PHILIP M ,  PAUL EASTWOOD ,  SHUJAATH MEHDI ,  STEFANY DAVID W ,  YON MUSICK KWON ,  MOORCROFT NEIL D ,  SUNGTAEK LIM ,  ZIQI JIANG JOHN ,  HARTMUT RUTTEN ,  STEFAN PEUKERT ,  UWE SCHWAHN

IPC: A61K31/44 ,  C07D213/62 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14 ,  C07D213/00

Abstract: La presente invención se refiere a una serie de derivados de piridona 2,3,5-sustituidos de fórmula I en la que R, R1, R2, R3 y R4 son tales como se definieron en la Memoria Descriptiva, y a métodos para fabricar estos compuestos. Los compuestos de esta invención son inhibidores de la poli(adenosina 5' -difosfato ribosa)-polimerasa (PARP) y son útiles como agentes farmacéuticos en el tratamiento y/o prevención de una diversidad de enfermedades, incluyendo enfermedades asociadas con el sistema nervioso central, y trastornos cardiovasculares.

公开(公告)号：CA2561280A1

公开(公告)日：2005-10-20

申请号：CA2561280

申请日：2005-03-29

Applicant: AVENTIS PHARMA INC

Inventor： WEINTRAUB PHILIP M ,  MEHDI SHUJAATH ,  PEUKERT STEFAN ,  EASTWOOD PAUL R ,  STEFANY DAVID W ,  LIM SUNGTAEK ,  SCHWAHN UWE ,  MOORCROFT NEIL ,  MUSICK KWON YON ,  JIANG JOHN Z ,  RUTTEN HARTMUT

IPC: C07D213/62 ,  A61K31/44 ,  A61P9/00 ,  A61P9/10 ,  A61P19/02 ,  A61P25/28 ,  A61P29/00 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to metho ds of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or preventi on of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.