Patent search ap:("AVENTIS PHARMA INC") AND inv:"GROSS ALEXANDRE" Page 1

1.

发明专利
1-(2H-pirazol-3-il)-3-(4-(1-(benzoil)-piperidin-4-ilmetil)-fenil)-urea derivati in sorodne spojine kot inhibitorji p38 kinaze in/ali TNF inhibitorji za zdravljenje vnetij 未知

公开(公告)号：SI1622610T1

公开(公告)日：2007-04-30

申请号：SI200430166

申请日：2004-05-05

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING DAVID R , GROSS ALEXANDRE , SHUM PATRICK WAI-KWOK , WILLARD NICOLE , FREED BRIAN S

IPC: A61K31/00 , A61P29/00 , C07D401/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/00 , C07D451/02 , C07D471/04

2.

发明专利
未知

公开(公告)号：DE602004003806T2

公开(公告)日：2007-11-22

申请号：DE602004003806

申请日：2004-05-05

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING R , GROSS ALEXANDRE , SHUM WAI-KWOK , WILLARD NICOLE , FREED S

IPC: A61K31/4155 , A61P29/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04

Abstract: The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).

3.

发明专利
未知

公开(公告)号：AT361910T

公开(公告)日：2007-06-15

申请号：AT03721841

申请日：2003-04-23

Applicant: AVENTIS PHARMA INC

Inventor： MERRIMAN GREGORY , WEINTRAUB PHILIP , SABOL JEFFREY , DHARANIPRAGADA RAMALINGA , HRIB NICHOLAS , JURCAK JOHN , GROSS ALEXANDRE , WHITELEY BRIAN , MUSICK KWON , KLEIN JOSEPH

IPC: C07D209/42 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/4436 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/08 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D417/14

4.

发明专利
未知

公开(公告)号：DE602004003806D1

公开(公告)日：2007-02-01

申请号：DE602004003806

申请日：2004-05-05

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING R , GROSS ALEXANDRE , SHUM WAI-KWOK , WILLARD NICOLE , FREED S

IPC: A61K31/4155 , A61P29/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04

Abstract: The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).

5.

发明专利
PIRAZOLES COMO INHIDORES DE FACTOR DE NECROSIS TUMORAL 未知

公开(公告)号：PE05232005A1

公开(公告)日：2005-07-07

申请号：PE0004472004

申请日：2004-05-03

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING DAVID R , GROSS ALEXANDRE , SHUM PATRICK WAI-KWOK , WILLARD NICOLE , FREED BRIAN

IPC: A61K31/4155 , A61P29/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04

CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04

Abstract: SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I), EN DONDE LAS LINEAS PUNTEADAS REPRESENTAN UN PUENTE ETILENO OPCIONAL; R1 ES ALQUILO, CICLOALQUILO, ARILO O PIRIDILO, PUDIENDO ESTOS DOS ULTIMOS, ESTAR SUSTITUIDOS POR ALQUILO, ALCOXI Y AMINO; R2 ES ALQUILO, CICLOALQUILO OPCIONALMENTE SUSTITUIDO, O ES ARILALQUILO SUSTITUIDO CON ALQUILO O ALCOXI; X ES -C(O)-, -C(O)-CH2-, -S(O)2- O -NHC(O)-; A ES ALQUENILO, ALCOXI, ALCOXIALQUILO, ALQUILO, ALQUINILO, ARILO, ARILALQUILO, OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-(5-TERC-BUTIL-2-p-TOLIL-2H-PIRAZOL-3-IL)-3-{-[1-(1-METILCICLOPROPANOCARBONIL)PIPERIDIN-4-ILMETIL]FENIL}UREA, ESTER 4-METOXIFENILICO DEL ACIDO 4-{4-[3-(5-TERC-BUTIL-2-p-TOLIL-2H-PIRAZOL-3-IL)UREIDO]BENCIL}-1-CARBOXILICO, ESTER BENCILICO DEL ACIDO 4-{4-[3-(5-TERC-BUTIL-2p-TOLIL-2H-PIRAZOL-3-IL)UREIDO]BENCIL}PIPERIDIN-1-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASA p38 Y/O DEL FACTOR DE NECROSIS TUMORAL (TNF) Y SON UTILES PARA EL TRATAMIENTO DE AFECCIONES INFLAMATORIAS ASOCIADAS A LA PRODUCCION EXCESIVA DE TNF

6.

发明专利
1-(2H-PYRAZOL-3-YL)-3YL){4-'1-(BENZOYL)-PIPERIDIN-4-YLMETHYL!-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF IMFLAMMATIONS 未知

公开(公告)号：CA2524043A1

公开(公告)日：2004-11-25

申请号：CA2524043

申请日：2004-05-05

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING DAVID R , GROSS ALEXANDRE , SHUM PATRICK WAI-KWOK , FREED BRIAN S , WILLARD NICOLE

IPC: A61K31/4155 , A61P29/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04

Abstract: The present invention provides compounds of Formula (I) Wherein ( ) is an optional ethylene bridge; R1 is alkyl, cycloalkyl, aryl or aryl substituted with one or more substituents selected from alkyl, alkoxy and amino, or R1 i s pyridyl or pyridyl substituted with one or more substituents selected from alkyl, alkoxy and amino; R2 is optionally substituted alkyl, alkoxyalkyl, optionally substituted cycloalkylalkyl, arylalkyl, or R2 is arylalkyl substituted with one or more substituents selected from alkyl, alkoxy; X is - C(O)-, -C(O)-CH2-, -S(O)2-, or NH-C(O)- ; and A is optionally substituted alkyl or other substituents as defined in claim 1. Pharmaceutical compositio ns comprising such compounds, their preparation, and their pharmaceutical use i n the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF), such as asthma or joint inflammation.

7.

发明专利
1- (2h-pyrazol -3-yl) -3yl) {4-`1- (benzoyl) -piperidin-4-ylmethyl}-urea derivatives and related compounds as inhibitors of p38 kinase and /or TNF inhibitors for the treatment of imflammations 未知

公开(公告)号：AU2004238241A1

公开(公告)日：2004-11-25

申请号：AU2004238241

申请日：2004-05-05

Applicant: AVENTIS PHARMA INC

Inventor： WILLARD NICOLE , GROSS ALEXANDRE , SHUM PATRICK WAI-KWOK , FREED BRIAN S , BORCHERDING DAVID R

IPC: A61P29/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , A61K31/4155

Abstract: The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).

8.

发明专利
1-(2H-pyrazol-3-yl) -3 - {4-'1-(benzoyl)-piperidin-4-ylmethyl-phenyl}-urea derivatives and related compounds as inhibitors of P38 kinase and/or TNF inhibitors for the treatment of inflammations 未知

公开(公告)号：AU2010236021A1

公开(公告)日：2010-11-18

申请号：AU2010236021

申请日：2010-10-26

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING DAVID R , GROSS ALEXANDRE , SHUM PATRICK WAI-KWOK , WILLARD NICOLE , FREED BRIAN S

IPC: A61P29/00 , A61K31/4155 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04

Abstract: The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).

9.

发明专利
Payrazoles as Inhibitors of Tumor ‎Necrosis Factor.‎ 未知

公开(公告)号：JO2473B1

公开(公告)日：2009-01-20

申请号：JOP20040048

申请日：2004-04-25

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING DAVID R , FREED BRIAN S , GROSS ALEXANDRE , SHUM PATRICK WAI-KWOK , WILLARD NICOLE

IPC: A61P29/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04

Abstract: The present invention provides ‎compounds of Formula (I)‎ And ester prodrugs, pharmaceutically ‎acceptable salts or solvates of such ‎compounds; or ester prodrugs of such ‎salts or solvated; pharmaceutical ‎compositions comprising such ‎compounds, their preparation, and their ‎pharmaceutical use in the treatment of ‎disease states capable of being ‎modulated by the inhibition of p38 ‎kinase and/ or tumor necrosis factor ‎‎(TNF).‎

10.

发明专利
COMPUESTOS DERIVADOS DE 2H-PIRAZOL-3-IL DE FORMULA DEFINIDA, QUE ACTUAN COMO INHIBIDORES DE QUINASA P38 Y TNF; COMPOSICION FARMACEUTICA QUE COMPRENDE A UNO DE LOS COMPUESTOS; USO DE LA COMPOSICION EN LA PREPARACION DE UN MEDICAMENTO; Y USO DE LOS COM 未知

公开(公告)号：CL2004000965A1

公开(公告)日：2005-04-22

申请号：CL2004000965

申请日：2004-05-05

Applicant: AVENTIS PHARMA INC

Inventor： BORCHERDING DAVID R , SHUM PATRICK WAI-KWOK , WILLARD NICOLE , FREED BRIAN S. , GROSS ALEXANDRE

IPC: A61K31/4155 , A61P29/00 , C07D231/38 , C07D295/14 , C07D307/68 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D401/014

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