公开(公告)号：EP1278747A1

公开(公告)日：2003-01-29

申请号：EP01935065.1

申请日：2001-05-03

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  AGRIOS, Konstantinos A. ,  ALTENBACH, Robert, J. ,  DRIZIN, Irene ,  KORT, Michael, J.

IPC: C07D471/14 ,  C07D491/14 ,  C07D495/14 ,  C07D471/04 ,  A61K31/4745 ,  A61P13/10 ,  A61P15/00

CPC classification number: C07D471/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D471/14 ,  C07D491/14 ,  C07D495/14 ,  C07C47/565 ,  C07C47/55

Abstract: The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.

公开(公告)号：EP1278747B1

公开(公告)日：2006-08-23

申请号：EP01935065.1

申请日：2001-05-03

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William, A. ,  AGRIOS, Konstantinos A. ,  ALTENBACH, Robert, J. ,  DRIZIN, Irene ,  KORT, Michael, J.

IPC: C07D471/14 ,  C07D491/14 ,  C07D495/14 ,  C07D471/04 ,  A61K31/4745 ,  A61P13/10 ,  A61P15/00

CPC classification number: C07D471/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D471/14 ,  C07D491/14 ,  C07D495/14 ,  C07C47/565 ,  C07C47/55

Abstract: The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.

公开(公告)号：EP1278746A2

公开(公告)日：2003-01-29

申请号：EP01934990.1

申请日：2001-05-02

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  AGRIOS, Konstantinos A. ,  BASHA, Fatima Z. ,  CHEN, Yiyuan ,  KORT, Michael E. ,  KYM, Philip R. ,  TANG, Rui ,  TURNER, Sean C. ,  YI, Lin

IPC: C07D471/14 ,  A61K31/4353 ,  A61P15/00 ,  A61P21/00 ,  C07D471/04 ,  C07D491/048 ,  C07D495/14 ,  C07D491/056

CPC classification number: C07D471/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/30 ,  C07C45/63 ,  C07C205/44 ,  C07D471/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14 ,  C07C47/55

Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.