公开(公告)号：WO2009055749A1

公开(公告)日：2009-04-30

申请号：PCT/US2008/081229

申请日：2008-10-25

Applicant: ABBOTT LABORATORIES ,  PERNER, Richard J. ,  KOENIG, John R. ,  DIDOMENICO, Stanley, Jr. ,  BAYBURT, Erol, K. ,  DAANEN, Jerome, F. ,  GOMTSYAN, Arthur, R. ,  KORT, Michael E. ,  KYM, Philip R. ,  VASUDEVAN, Anil ,  SCHMIDT, Robert, G. ,  VOIGHT, Eric

Inventor： PERNER, Richard J. ,  KOENIG, John R. ,  DIDOMENICO, Stanley, Jr. ,  BAYBURT, Erol, K. ,  DAANEN, Jerome, F. ,  GOMTSYAN, Arthur, R. ,  KORT, Michael E. ,  KYM, Philip R. ,  VASUDEVAN, Anil ,  SCHMIDT, Robert, G. ,  VOIGHT, Eric

IPC: C07D263/48 ,  C07D413/04 ,  C07D413/12 ,  A61K31/421 ,  A61P29/00

CPC classification number: C07D413/12 ,  C07D263/48 ,  C07D413/04

Abstract: Compounds of formula (I) wherein R 1 , R 2 , R 4 , and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 在描述中定义R1，R2，R4和W的式（I）化合物是具有CNS穿透的TRPV1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010045402A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060734

申请日：2009-10-15

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D405/12 ,  C07D311/74

Abstract: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂合物，前药，前药盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2009089083A1

公开(公告)日：2009-07-16

申请号：PCT/US2009/030006

申请日：2009-01-02

Applicant: ABBOTT LABORATORIES ,  PERNER, Richard J. ,  KORT, Michael E. ,  DIDOMENICO, Stanley, Jr. ,  CHEN, Jun ,  VASUDEVAN, Anil

Inventor： PERNER, Richard J. ,  KORT, Michael E. ,  DIDOMENICO, Stanley, Jr. ,  CHEN, Jun ,  VASUDEVAN, Anil

IPC: C07D213/53 ,  C07D215/12 ,  C07D217/14 ,  C07D333/20 ,  A61K31/4406 ,  A61P29/00

CPC classification number: C07D333/22 ,  A61K31/381 ,  A61K31/44 ,  A61K31/47 ,  A61K31/472 ,  A61K45/06 ,  C07D213/53 ,  C07D213/61 ,  C07D213/64 ,  C07D215/12 ,  C07D217/14 ,  C07D333/20

Abstract: Compounds of formula (I), wherein R 1 , R 2 , R 3 , and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 其中R1，R2，R3和Y在说明书中定义的式（I）化合物是TRPA1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010045401A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060732

申请日：2009-10-15

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D311/74 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，溶剂合物，前药，前药的盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2009055629A2

公开(公告)日：2009-04-30

申请号：PCT/US2008/081042

申请日：2008-10-24

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  BAYBURT, Erol K. ,  DAANEN, Jerome, F. ,  KORT, Michael E.

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  BAYBURT, Erol K. ,  DAANEN, Jerome, F. ,  KORT, Michael E.

CPC classification number: C07D213/62 ,  C07D213/06 ,  C07D277/22

Abstract: The present invention relates to compounds of formula (I), wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , m, and n are defined in the specification are TRPV1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5，m和n在本说明书中定义为TRPV1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2004099154A2

公开(公告)日：2004-11-18

申请号：PCT/US2004/013530

申请日：2004-04-29

Applicant: ABBOTT LABORATORIES ,  ATKINSON, Robert, N. ,  DRIZEN, Irene ,  GREGG, Robert, J. ,  GROSS, Michael, F. ,  KORT, Michael E. ,  SHI, Lei

Inventor： ATKINSON, Robert, N. ,  DRIZEN, Irene ,  GREGG, Robert, J. ,  GROSS, Michael, F. ,  KORT, Michael E. ,  SHI, Lei

IPC: C07D231/00

CPC classification number: C07D401/04 ,  A61K31/416 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D231/14 ,  C07D231/20 ,  C07D231/22 ,  C07D231/24 ,  C07D401/12

Abstract: Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.

Abstract translation: 本发明化合物调节哺乳动物中的PN3，可用于治疗哺乳动物的疼痛。

公开(公告)号：EP2240450A1

公开(公告)日：2010-10-20

申请号：EP09700714.0

申请日：2009-01-02

Applicant: Abbott Laboratories

Inventor： PERNER, Richard J. ,  KORT, Michael E. ,  DIDOMENICO, Stanley, Jr. ,  CHEN, Jun ,  VASUDEVAN, Anil

IPC: C07D213/53 ,  C07D215/12 ,  C07D217/14 ,  C07D333/20 ,  A61K31/4406 ,  A61P29/00

CPC classification number: C07D333/22 ,  A61K31/381 ,  A61K31/44 ,  A61K31/47 ,  A61K31/472 ,  A61K45/06 ,  C07D213/53 ,  C07D213/61 ,  C07D213/64 ,  C07D215/12 ,  C07D217/14 ,  C07D333/20

Abstract: Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2352726A1

公开(公告)日：2011-08-10

申请号：EP09740591.4

申请日：2009-10-15

Applicant: Abbott Laboratories

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D311/74 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R
1 , R
2 , R
3 , R
4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP1299392A2

公开(公告)日：2003-04-09

申请号：EP01948754.5

申请日：2001-06-27

Applicant: Abbott Laboratories ,  LIGAND PHARMACEUTICALS INCORPORATED

Inventor： COGHLAN, Michael J. ,  EDWARDS, James P. ,  ELMORE, Steven W. ,  JONES, Todd K. ,  KORT, Michael E. ,  KYM, Philip R. ,  MOORE, Jimmie L. ,  PRATT, John K. ,  WANG, Alan X.

IPC: C07D491/04 ,  A61K31/435

CPC classification number: C07D491/04

Abstract: Compounds having formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of formula I and methods of inhibiting immune or autoimmune diseases in a mammal.

公开(公告)号：EP2215061A2

公开(公告)日：2010-08-11

申请号：EP08842703.4

申请日：2008-10-24

Applicant: Abbott Laboratories

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  BAYBURT, Erol K. ,  DAANEN, Jerome, F. ,  KORT, Michael E.

IPC: C07D213/06 ,  C07D213/62 ,  C07D277/22 ,  A61K31/44 ,  A61K31/426 ,  A61P29/00

CPC classification number: C07D213/62 ,  C07D213/06 ,  C07D277/22

Abstract: The present invention relates to compounds of formula (I), wherein X, R1, R2, R3, R4, R5, m, and n are defined in the specification are TRPV1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.