公开(公告)号：WO2011053476A1

公开(公告)日：2011-05-05

申请号：PCT/US2010/053047

申请日：2010-10-18

Applicant: ABBOTT LABORATORIES ,  BA-MAUNG, Nwe Y. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  KAWAI, Megumi ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSON, Bryan K. ,  WANG, Gary T.

Inventor： BA-MAUNG, Nwe Y. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  KAWAI, Megumi ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSON, Bryan K. ,  WANG, Gary T.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).

Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。 式（I）。

公开(公告)号：WO2009070516A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084469

申请日：2008-11-24

Applicant: ABBOTT LABORATORIES ,  BAMAUNG, Nwe Y. ,  BELL, Randy L. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  HUBBARD, Robert D. ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSEN, Bryan K. ,  WANG, Gary T. ,  WANG, Jieyi ,  SARRIS, Kathy

Inventor： BAMAUNG, Nwe Y. ,  BELL, Randy L. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  HUBBARD, Robert D. ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSEN, Bryan K. ,  WANG, Gary T. ,  WANG, Jieyi ,  SARRIS, Kathy

IPC: C07D513/04 ,  A61K31/425 ,  A61P35/00

CPC classification number: C07D513/04

Abstract: Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A 1 is R 1 , OR 1 . NHR 1 , N(R 1 ) 2, NHC(O)R 1 , NHC(O)NHR 1 , NHC(O)N(R 1 ) 2 , NHC(O)OR 1 , C(O)NHR 1 , C(O)N(R 1 ) 2 , C=NOR 1 , or C(NH 2 )NOC(O)R 1 ;

Abstract translation: 公开了抑制蛋白激酶的式I化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。 式I及其前药的其治疗上可接受的盐，前药和盐，其中X为CH或N; A1为R1，OR1。 NH（O）N（R1）2，NHC（O）R1，NHC（O）NHR1，NHC（O）N（R1）2，NHC（O）OR1，C（O）NHR1，C（O） 2，C = NOR1或C（NH 2）NOC（O）R 1;

公开(公告)号：EP2496574A1

公开(公告)日：2012-09-12

申请号：EP10768675.0

申请日：2010-10-18

Applicant: Abbott Laboratories

Inventor： BA-MAUNG, Nwe Y. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  KAWAI, Megumi ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSON, Bryan K. ,  WANG, Gary T.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).

公开(公告)号：EP2222682A1

公开(公告)日：2010-09-01

申请号：EP08855224.5

申请日：2008-11-24

Applicant: Abbott Laboratories

Inventor： BAMAUNG, Nwe Y. ,  BELL, Randy L. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  HUBBARD, Robert D. ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSEN, Bryan K. ,  WANG, Gary T. ,  WANG, Jieyi ,  SARRIS, Kathy

IPC: C07D513/04 ,  A61K31/425 ,  A61P35/00

CPC classification number: C07D513/04

Abstract: Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1;