-
1.发明申请IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION 审中-公开咪达唑啶作为多发性激酶抑制剂的新型SCAFF
公开(公告)号：WO2011053476A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/053047
申请日：2010-10-18
Applicant: ABBOTT LABORATORIES , BA-MAUNG, Nwe Y. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , KAWAI, Megumi , MANTEI, Robert A. , SHEPPARD, George S. , SORENSON, Bryan K. , WANG, Gary T.
Inventor： BA-MAUNG, Nwe Y. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , KAWAI, Megumi , MANTEI, Robert A. , SHEPPARD, George S. , SORENSON, Bryan K. , WANG, Gary T.
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).
Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。 式（I）。
-
2.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：WO2010138588A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036198
申请日：2010-05-26
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
-
3.发明申请
公开(公告)号：WO2011068560A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/036844
申请日：2010-06-01
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
公开(公告)号：WO2009070516A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/084469
申请日：2008-11-24
Applicant: ABBOTT LABORATORIES , BAMAUNG, Nwe Y. , BELL, Randy L. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , HUBBARD, Robert D. , MANTEI, Robert A. , SHEPPARD, George S. , SORENSEN, Bryan K. , WANG, Gary T. , WANG, Jieyi , SARRIS, Kathy
Inventor： BAMAUNG, Nwe Y. , BELL, Randy L. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , HUBBARD, Robert D. , MANTEI, Robert A. , SHEPPARD, George S. , SORENSEN, Bryan K. , WANG, Gary T. , WANG, Jieyi , SARRIS, Kathy
IPC: C07D513/04 , A61K31/425 , A61P35/00
CPC classification number: C07D513/04
Abstract: Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A 1 is R 1 , OR 1 . NHR 1 , N(R 1 ) 2, NHC(O)R 1 , NHC(O)NHR 1 , NHC(O)N(R 1 ) 2 , NHC(O)OR 1 , C(O)NHR 1 , C(O)N(R 1 ) 2 , C=NOR 1 , or C(NH 2 )NOC(O)R 1 ;
Abstract translation: 公开了抑制蛋白激酶的式I化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。 式I及其前药的其治疗上可接受的盐，前药和盐，其中X为CH或N; A1为R1，OR1。 NH（O）N（R1）2，NHC（O）R1，NHC（O）NHR1，NHC（O）N（R1）2，NHC（O）OR1，C（O）NHR1，C（O） 2，C = NOR1或C（NH 2）NOC（O）R 1;
-
Patent Agency Ranking5.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：EP2507211A1
公开(公告)日：2012-10-10
申请号：EP10722500.5
申请日：2010-06-01
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
-
6.发明公开PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES 审中-公开吡咯烷衍生物，其制备方法及其用途作为抑制剂neuramidases
公开(公告)号：EP1358154A2
公开(公告)日：2003-11-05
申请号：EP00972042.6
申请日：2000-10-10
Applicant: Abbott Laboratories
Inventor： MARING, Clarence J. , GIRANDA, Vincent L. , KEMPF, Dale J. , STOLL, Vincent S. , SUN, Minghua , ZHAO, Chen , GU, Yu Gui , HANESSIAN, Stephen , WANG, Gary T. , KRUEGER, Allan C. , CHEN, Hui-Ju , CHEN, Yuanwei , DEGOEY, David A. , FLOSI, William J. , GRAMPOVNIK, David J. , KATI, Warren M. , KENNEDY, April L. , KLEIN, Larry L. , LIN, Zhen , MADIGAN, Darold L. , MCDANIEL, Keith F. , MUCHMORE, Steven W. , SHAM, Hing L. , STEWART, Kent D. , TU, Noah P. , WAGENAAR, Frank L. , WANG, Sheldon , WIEDEMAN, Paul E. , XU, Yibo , YEUNG, Ming C. , BAYRAKDARIAN, Malken , LUO, Xuehong
IPC: C07D207/16 , C07D403/04 , C07D417/04
CPC classification number: C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
-
7.发明公开
公开(公告)号：EP2222682A1
公开(公告)日：2010-09-01
申请号：EP08855224.5
申请日：2008-11-24
Applicant: Abbott Laboratories
Inventor： BAMAUNG, Nwe Y. , BELL, Randy L. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , HUBBARD, Robert D. , MANTEI, Robert A. , SHEPPARD, George S. , SORENSEN, Bryan K. , WANG, Gary T. , WANG, Jieyi , SARRIS, Kathy
IPC: C07D513/04 , A61K31/425 , A61P35/00
CPC classification number: C07D513/04
Abstract: Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1;
-
8.发明公开
公开(公告)号：EP2496574A1
公开(公告)日：2012-09-12
申请号：EP10768675.0
申请日：2010-10-18
Applicant: Abbott Laboratories
Inventor： BA-MAUNG, Nwe Y. , CLARK, Richard F. , ERICKSON, Scott A. , FIDANZE, Steve D. , KAWAI, Megumi , MANTEI, Robert A. , SHEPPARD, George S. , SORENSON, Bryan K. , WANG, Gary T.
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).
-
9.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂用于癌症和免疫球蛋白和自身免疫性疾病的治疗
公开(公告)号：EP2435432A2
公开(公告)日：2012-04-04
申请号：EP10721246.6
申请日：2010-05-26
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.052 seconds)
