公开(公告)号：WO2010045402A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060734

申请日：2009-10-15

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D405/12 ,  C07D311/74

Abstract: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂合物，前药，前药盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2012134943A1

公开(公告)日：2012-10-04

申请号：PCT/US2012/030096

申请日：2012-03-22

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur ,  DAANEN, Jerome F. ,  GFESSER, Gregory A. ,  KORT, Michael R. ,  LEE, Chih-Hung ,  MCDONALD, Heath A. ,  PUTTFARCKEN, Pamela S. ,  VOIGHT, Eric A. ,  KYM, Phil

Inventor： GOMTSYAN, Arthur ,  DAANEN, Jerome F. ,  GFESSER, Gregory A. ,  KORT, Michael R. ,  LEE, Chih-Hung ,  MCDONALD, Heath A. ,  PUTTFARCKEN, Pamela S. ,  VOIGHT, Eric A. ,  KYM, Phil

IPC: C07C275/32 ,  C07D231/54 ,  C07D413/12 ,  A61K31/17 ,  A61K31/416 ,  A61P13/10 ,  A61P25/04 ,  A61P29/00

CPC classification number: C07C275/32 ,  C07C2601/08 ,  C07C2602/08 ,  C07D209/08 ,  C07D215/38 ,  C07D217/02 ,  C07D231/56 ,  C07D239/80 ,  C07D263/48 ,  C07D265/36 ,  C07D401/04 ,  C07D413/12 ,  C07D417/12

Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, (I) wherein X 1 , X 2 , X 3 , X 4 , J, K, L, X 5 , X 6 , R b , G 2 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂化物或其组合，其中X1，X2，X3，X4，J，K，L，X5，X6，Rb，G2和m被定义 在规范中。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010045401A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060732

申请日：2009-10-15

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D311/74 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，溶剂合物，前药，前药的盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：EP2352726A1

公开(公告)日：2011-08-10

申请号：EP09740591.4

申请日：2009-10-15

Applicant: Abbott Laboratories

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D311/74 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R
1 , R
2 , R
3 , R
4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2352727A1

公开(公告)日：2011-08-10

申请号：EP09740592.2

申请日：2009-10-15

Applicant: Abbott Laboratories

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D405/12 ,  C07D311/74

Abstract: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，溶剂化物，前药，前药的盐或其组合，其中R 1，R 2，R 3，R 4和m在说明书中定义。 还公开了包含此类化合物的组合物以及使用此类化合物和组合物治疗疾病和病症的方法。