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公开(公告)号：WO2012040404A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/052668
申请日：2011-09-21
Applicant: ABBOTT LABORATORIES , CHEN, Shuang , NAPIER, James J. , ZHANG, Geoff G. Z. , BRACKEMEYER, Paul J.
Inventor： CHEN, Shuang , NAPIER, James J. , ZHANG, Geoff G. Z. , BRACKEMEYER, Paul J.
IPC: C07D471/08 , A61K31/439 , A61P25/00 , A61P25/28
CPC classification number: C07D451/14 , A61K31/439 , A61K45/06 , C07D471/08
Abstract: The invention relates to a crystalline monohydrate of ( 4s )-4-(5-phenyl-1,3,4- thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.1 3,7 ]decane dihydrogen citrate, compositions comprising such compound, and a process for preparing such compound.
Abstract translation: 本发明涉及（4s）-4-（5-苯基-1,3,4-噻二唑-2-基氧基）-1-氮杂三环[3.3.1.13,7]癸烷二氢二氢柠檬酸盐的结晶一水合物，包含这种化合物 ，以及这种化合物的制备方法。
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2.发明公开PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES 有权用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
公开(公告)号：EP1272500A2
公开(公告)日：2003-01-08
申请号：EP00942860.8
申请日：2000-06-15
Applicant: Abbott Laboratories
Inventor： STONER, Eric J. , PETERSON, Matthew J. , KU, Yi-Yin , CINK, Russell D. , COOPER, Arthur J. , DESHPANDE, Mahendra N. , GRIEME, Tim , HAIGHT, Anthony R. , HILL, David R. , HSU, Margaret, Chi-Ping , KING, Steven A. , LEANNA, Marvin R. , LEE, Elaine C. , MCLAUGHLIN, Maureen A. , MORTON, Howard E. , NAPIER, James J. , PLATA, Daniel J. , RAJE, Prasad S. , RASMUSSEN, Michael , RILEY, David , TIEN, Jien-Heh J. , WITTENBERGER, Steven J.
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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3.发明授权PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES 有权用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
公开(公告)号：EP1272500B1
公开(公告)日：2005-05-04
申请号：EP00942860.8
申请日：2000-06-15
Applicant: Abbott Laboratories
Inventor： STONER, Eric J. , PETERSON, Matthew J. , KU, Yi-Yin , CINK, Russell D. , COOPER, Arthur J. , DESHPANDE, Mahendra N. , GRIEME, Tim , HAIGHT, Anthony R. , HILL, David R. , HSU, Margaret, Chi-Ping , KING, Steven A. , LEANNA, Marvin R. , LEE, Elaine C. , MCLAUGHLIN, Maureen A. , MORTON, Howard E. , NAPIER, James J. , PLATA, Daniel J. , RAJE, Prasad S. , RASMUSSEN, Michael , RILEY, David , TIEN, Jien-Heh J. , WITTENBERGER, Steven J.
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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