-
公开(公告)号：WO2008014222A1
公开(公告)日：2008-01-31
申请号：PCT/US2007/074159
申请日：2007-07-24
Applicant: ABBOTT LABORATORIES , VISWANATH, Shekhar , BARTELT, Larry , LEANNA, Robert , RASMUSSEN, Michael , DHAON, Madhup , HENRY, Rodger , BORCHARDT, Thomas , CHEN, Shuang , ZHANG, Geoff
Inventor： VISWANATH, Shekhar , BARTELT, Larry , LEANNA, Robert , RASMUSSEN, Michael , DHAON, Madhup , HENRY, Rodger , BORCHARDT, Thomas , CHEN, Shuang , ZHANG, Geoff
IPC: C07D498/18 , A61K31/395 , A61P37/06 , A61K31/4353
CPC classification number: C07D498/18
Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)
Abstract translation: 雷帕霉素类似物组合物包括雷帕霉素类似物的结晶形式。 该晶体可以是水合物，脱水剂，溶剂化物或去溶剂化物。 雷帕霉素类似物可以具有式（I）的结构，其可任选地是前药，盐，衍生物或其组合：式（I）
-
公开(公告)号：EP2051984A1
公开(公告)日：2009-04-29
申请号：EP07799771.6
申请日：2007-07-24
Applicant: ABBOTT LABORATORIES
Inventor： VISWANATH, Shekhar , BARTELT, Larry , LEANNA, Robert , RASMUSSEN, Michael , DHAON, Madhup , HENRY, Rodger , BORCHARDT, Thomas , CHEN, Shuang , ZHANG, Geoff
IPC: C07D498/18 , A61K31/395 , A61P37/06 , A61K31/4353
CPC classification number: C07D498/18
Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)
Abstract translation: 雷帕霉素类似物组合物包括雷帕霉素类似物的结晶形式。 晶体可以是水合物，脱水物，溶剂化物或去溶剂化物。 雷帕霉素类似物可具有式（I）的结构，其任选为前药，盐，衍生物或其组合：式（I）
-
3.发明公开PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES 有权用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
公开(公告)号：EP1272500A2
公开(公告)日：2003-01-08
申请号：EP00942860.8
申请日：2000-06-15
Applicant: Abbott Laboratories
Inventor： STONER, Eric J. , PETERSON, Matthew J. , KU, Yi-Yin , CINK, Russell D. , COOPER, Arthur J. , DESHPANDE, Mahendra N. , GRIEME, Tim , HAIGHT, Anthony R. , HILL, David R. , HSU, Margaret, Chi-Ping , KING, Steven A. , LEANNA, Marvin R. , LEE, Elaine C. , MCLAUGHLIN, Maureen A. , MORTON, Howard E. , NAPIER, James J. , PLATA, Daniel J. , RAJE, Prasad S. , RASMUSSEN, Michael , RILEY, David , TIEN, Jien-Heh J. , WITTENBERGER, Steven J.
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
-
4.发明授权PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES 有权用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
公开(公告)号：EP1272500B1
公开(公告)日：2005-05-04
申请号：EP00942860.8
申请日：2000-06-15
Applicant: Abbott Laboratories
Inventor： STONER, Eric J. , PETERSON, Matthew J. , KU, Yi-Yin , CINK, Russell D. , COOPER, Arthur J. , DESHPANDE, Mahendra N. , GRIEME, Tim , HAIGHT, Anthony R. , HILL, David R. , HSU, Margaret, Chi-Ping , KING, Steven A. , LEANNA, Marvin R. , LEE, Elaine C. , MCLAUGHLIN, Maureen A. , MORTON, Howard E. , NAPIER, James J. , PLATA, Daniel J. , RAJE, Prasad S. , RASMUSSEN, Michael , RILEY, David , TIEN, Jien-Heh J. , WITTENBERGER, Steven J.
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
-
-
-
Search Results
4
records
(took 0.022 seconds)
