公开(公告)号：WO2008060767A3

公开(公告)日：2008-05-22

申请号：PCT/US2007/080133

申请日：2007-10-02

Applicant: ABBOTT LABORATORIES ,  ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  COWART, Marlon D ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D.

Inventor： ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  COWART, Marlon D ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D.

IPC: C07D491/04 ,  C07D493/04 ,  C07H17/04

Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

公开(公告)号：WO2009085945A1

公开(公告)日：2009-07-09

申请号：PCT/US2008/087413

申请日：2008-12-18

Applicant: ABBOTT LABORATORIES ,  BLACK, Lawrence A. ,  COWART, Marlon D. ,  GFESSER, Gregory A. ,  WAKEFIELD, Brian D. ,  ALTENBACH, Robert J. ,  LIU, Huaqing ,  ZHAO, Chen ,  HSIEH, Gin C.

Inventor： BLACK, Lawrence A. ,  COWART, Marlon D. ,  GFESSER, Gregory A. ,  WAKEFIELD, Brian D. ,  ALTENBACH, Robert J. ,  LIU, Huaqing ,  ZHAO, Chen ,  HSIEH, Gin C.

IPC: A61K31/423 ,  A61K31/428 ,  C07D413/14 ,  C07D417/14 ,  A61P25/00 ,  A61P3/10

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

Abstract translation: 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。

公开(公告)号：EP2237779A1

公开(公告)日：2010-10-13

申请号：EP08867156.5

申请日：2008-12-18

Applicant: Abbott Laboratories

Inventor： BLACK, Lawrence A. ,  COWART, Marlon D. ,  GFESSER, Gregory A. ,  WAKEFIELD, Brian D. ,  ALTENBACH, Robert J. ,  LIU, Huaqing ,  ZHAO, Chen ,  HSIEH, Gin C.

IPC: A61K31/423 ,  A61K31/428 ,  C07D413/14 ,  C07D417/14 ,  A61P25/00 ,  A61P3/10

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.