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公开(公告)号：WO2010036998A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/058553
申请日：2009-09-28
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
Inventor： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana , HU, Min
IPC: A61K31/439 , C12Q1/02 , C07D471/08
CPC classification number: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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公开(公告)号：WO2008002956A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/072185
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
CPC classification number: C07D417/04 , C07D413/04 , C07D417/14
Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
Abstract translation: 本发明涉及一系列噻唑啉和恶唑啉衍生物，其组合物，以及使用这些化合物治疗病症和病症的方法。
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公开(公告)号：WO2011008312A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/027931
申请日：2010-03-19
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
Inventor： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
IPC: C07D487/18
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a , R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物， R 1，R 2，R 3，R 4，R 5，R 5，R 5，R 4， U，V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法以及鉴定此类化合物的方法。
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公开(公告)号：WO2009085945A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087413
申请日：2008-12-18
Applicant: ABBOTT LABORATORIES , BLACK, Lawrence A. , COWART, Marlon D. , GFESSER, Gregory A. , WAKEFIELD, Brian D. , ALTENBACH, Robert J. , LIU, Huaqing , ZHAO, Chen , HSIEH, Gin C.
Inventor： BLACK, Lawrence A. , COWART, Marlon D. , GFESSER, Gregory A. , WAKEFIELD, Brian D. , ALTENBACH, Robert J. , LIU, Huaqing , ZHAO, Chen , HSIEH, Gin C.
IPC: A61K31/423 , A61K31/428 , C07D413/14 , C07D417/14 , A61P25/00 , A61P3/10
CPC classification number: C07D417/14 , C07D413/04 , C07D417/04
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
Abstract translation: 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了式（I）化合物的药物组合物，使用这些化合物和组合物的方法及其制备方法。
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公开(公告)号：WO2008002974A1
公开(公告)日：2008-01-03
申请号：PCT/US2007/072228
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
IPC: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , A61K31/402 , A61P25/00
CPC classification number: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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Patent Agency Ranking
公开(公告)号：WO2012134943A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/030096
申请日：2012-03-22
Applicant: ABBOTT LABORATORIES , GOMTSYAN, Arthur , DAANEN, Jerome F. , GFESSER, Gregory A. , KORT, Michael R. , LEE, Chih-Hung , MCDONALD, Heath A. , PUTTFARCKEN, Pamela S. , VOIGHT, Eric A. , KYM, Phil
Inventor： GOMTSYAN, Arthur , DAANEN, Jerome F. , GFESSER, Gregory A. , KORT, Michael R. , LEE, Chih-Hung , MCDONALD, Heath A. , PUTTFARCKEN, Pamela S. , VOIGHT, Eric A. , KYM, Phil
IPC: C07C275/32 , C07D231/54 , C07D413/12 , A61K31/17 , A61K31/416 , A61P13/10 , A61P25/04 , A61P29/00
CPC classification number: C07C275/32 , C07C2601/08 , C07C2602/08 , C07D209/08 , C07D215/38 , C07D217/02 , C07D231/56 , C07D239/80 , C07D263/48 , C07D265/36 , C07D401/04 , C07D413/12 , C07D417/12
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, (I) wherein X 1 , X 2 , X 3 , X 4 , J, K, L, X 5 , X 6 , R b , G 2 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂化物或其组合，其中X1，X2，X3，X4，J，K，L，X5，X6，Rb，G2和m被定义 在规范中。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：WO2010151815A3
公开(公告)日：2010-12-29
申请号：PCT/US2010/040064
申请日：2010-06-25
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , NERSESIAN, Diana L. , LEE, Chih-Hung , FAGHIH, Ramin , GFESSER, Gregory A.
Inventor： SCHRIMPF, Michael R. , NERSESIAN, Diana L. , LEE, Chih-Hung , FAGHIH, Ramin , GFESSER, Gregory A.
IPC: C07D487/10 , C07D471/02 , A61K31/438 , A61P25/28
Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 postive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
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公开(公告)号：WO2009082698A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/087729
申请日：2008-12-19
Applicant: ABBOTT LABORATORIES , RUETER, Lynne E. , FOX, Gerard B. , BROWMAN, Kaitlin E. , SULLIVAN, James P. , BRIONI, Jorge D. , COWART, Marlon D. , FAGHIH, Ramin , GFESSER, Gregory A. , MORTELL, Kathleen H. , GOPALAKRISHNAN, Murali
Inventor： RUETER, Lynne E. , FOX, Gerard B. , BROWMAN, Kaitlin E. , SULLIVAN, James P. , BRIONI, Jorge D. , COWART, Marlon D. , FAGHIH, Ramin , GFESSER, Gregory A. , MORTELL, Kathleen H. , GOPALAKRISHNAN, Murali
CPC classification number: A61K45/06 , A61K31/165 , A61K31/40 , A61K2300/00
Abstract: The present invention relates to compositions for treatment of cognitive deficits. Such compositions can have a nicotinic acetylcholine receptor ligand, of either α4ß2 subtype or α7 nicotinic acetylcholine subtype, and a histamine-3 receptor ligand, a method of using the same, and a related article of manufacture. Combinations of such active agents with psychostimulants or monoamine reuptake inhibitors also is contemplated.
Abstract translation: 本发明涉及用于治疗认知缺陷的组合物。 这样的组合物可以具有a4β2亚型或a7烟碱型乙酰胆碱亚型的烟碱型乙酰胆碱受体配体，组胺3受体配体，使用该配体的方法和相关制品。 也考虑了这些活性剂与精神兴奋剂或单胺再摄取抑制剂的组合。
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公开(公告)号：EP2237779A1
公开(公告)日：2010-10-13
申请号：EP08867156.5
申请日：2008-12-18
Applicant: Abbott Laboratories
Inventor： BLACK, Lawrence A. , COWART, Marlon D. , GFESSER, Gregory A. , WAKEFIELD, Brian D. , ALTENBACH, Robert J. , LIU, Huaqing , ZHAO, Chen , HSIEH, Gin C.
IPC: A61K31/423 , A61K31/428 , C07D413/14 , C07D417/14 , A61P25/00 , A61P3/10
CPC classification number: C07D417/14 , C07D413/04 , C07D417/04
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
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公开(公告)号：EP2041085A1
公开(公告)日：2009-04-01
申请号：EP07812375.9
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
IPC: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , A61K31/402 , A61P25/00
CPC classification number: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
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