公开(公告)号：WO2011068881A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058572

申请日：2010-12-01

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC: A01N43/58

CPC classification number: C07D487/14 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides compounds of Formula (I) and Formula (II), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）和式（II）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2008060621A3

公开(公告)日：2008-05-22

申请号：PCT/US2007/024076

申请日：2007-11-16

Applicant: ABBOTT LABORATORIES ,  GEORGE, Dawn M. ,  DIXON, Richard W. ,  FRIEDMAN, Michael ,  HOBSON, Adrian ,  LI, Biqin ,  WANG, Lu ,  WU, Xiaoyun ,  WISHART, Neil

Inventor： GEORGE, Dawn M. ,  DIXON, Richard W. ,  FRIEDMAN, Michael ,  HOBSON, Adrian ,  LI, Biqin ,  WANG, Lu ,  WU, Xiaoyun ,  WISHART, Neil

IPC: A61K31/445 ,  C07D211/00

Abstract: The present invention is directed to novel aminopyrrolidines of formula (I), pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

公开(公告)号：WO2011079105A1

公开(公告)日：2011-06-30

申请号：PCT/US2010/061475

申请日：2010-12-21

Applicant: ABBOTT LABORATORIES ,  ERICSSON, Anna M. ,  EDMUNDS, Jeremy J. ,  HOBSON, Adrian D. ,  STEWART, Kent D. ,  WISHART, Neil ,  WANG, Lei ,  IHLE, David C. ,  FERENZ, Catherine R. ,  DUNSTAN, Theresa A. ,  WANG, Lu

Inventor： ERICSSON, Anna M. ,  EDMUNDS, Jeremy J. ,  HOBSON, Adrian D. ,  STEWART, Kent D. ,  WISHART, Neil ,  WANG, Lei ,  IHLE, David C. ,  FERENZ, Catherine R. ,  DUNSTAN, Theresa A. ,  WANG, Lu

IPC: C07D265/00

CPC classification number: C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D498/04

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2007117465A2

公开(公告)日：2007-10-18

申请号：PCT/US2007/008307

申请日：2007-04-02

Applicant: ABBOTT LABORATORIES ,  ERICSSON, Anna M. ,  BURCHAT, Andrew ,  FRANK, Kristine E. ,  CALDERWOOD, David J. ,  ABBOTT, Lily K. ,  ARGIRIADI, Maria A. ,  BORHANI, David W. ,  CUSACK, Kevin P. ,  DIXON, Richard W. ,  GORDON, Thomas D. ,  MULLEN, Kelly D. ,  TALANIAN, Robert V. ,  WU, Xiaoyun ,  ZHANG, Xiaolei ,  WANG, Lu X. ,  LI, Biqin ,  BARBERIS, Claude E. ,  WISHART, Neil

Inventor： ERICSSON, Anna M. ,  BURCHAT, Andrew ,  FRANK, Kristine E. ,  CALDERWOOD, David J. ,  ABBOTT, Lily K. ,  ARGIRIADI, Maria A. ,  BORHANI, David W. ,  CUSACK, Kevin P. ,  DIXON, Richard W. ,  GORDON, Thomas D. ,  MULLEN, Kelly D. ,  TALANIAN, Robert V. ,  WU, Xiaoyun ,  ZHANG, Xiaolei ,  WANG, Lu X. ,  LI, Biqin ,  BARBERIS, Claude E. ,  WISHART, Neil

IPC: A61K31/5377

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：WO2011068899A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058598

申请日：2010-12-01

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  ARGIRIADI, Maria A. ,  BREINLINGER, Eric C. ,  CALDERWOOD, David J. ,  ERICSSON, Anna M. ,  FIAMENGO, Bryan A. ,  FRANK, Kristine E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn M. ,  GOEDKEN, Eric R. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  MORYTKO, Michael J. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  STEWART, Kent D. ,  VOSS, Jeffrey W. ,  WALLACE, Grier A. ,  WANG, Lu ,  WOLLER, Kevin R.

Inventor： WISHART, Neil ,  ARGIRIADI, Maria A. ,  BREINLINGER, Eric C. ,  CALDERWOOD, David J. ,  ERICSSON, Anna M. ,  FIAMENGO, Bryan A. ,  FRANK, Kristine E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn M. ,  GOEDKEN, Eric R. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  MORYTKO, Michael J. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  STEWART, Kent D. ,  VOSS, Jeffrey W. ,  WALLACE, Grier A. ,  WANG, Lu ,  WOLLER, Kevin R.

IPC: A01N43/42 ,  A61K31/44

CPC classification number: C07F9/06 ,  C07D471/14 ,  C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii），（Ij），（Ik） ，或（II），其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2008060767A3

公开(公告)日：2008-05-22

申请号：PCT/US2007/080133

申请日：2007-10-02

Applicant: ABBOTT LABORATORIES ,  ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  COWART, Marlon D ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D.

Inventor： ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  COWART, Marlon D ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D.

IPC: C07D491/04 ,  C07D493/04 ,  C07H17/04

Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

公开(公告)号：WO2008060766A2

公开(公告)日：2008-05-22

申请号：PCT/US2007/080132

申请日：2007-10-02

Applicant: ABBOTT LABORATORIES ,  COWART, Marlon D ,  ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D

Inventor： ALTENBACH, Robert J ,  LIU, Huaqing ,  DRIZIN, Irene ,  WISHART, Neil ,  BABINSKI, David J ,  GREGG, Robert J ,  ESBENSHADE, Timothy A ,  HSIEH, Gin C ,  BRIONI, Jorge D ,  HONORE, Marie P ,  BLACK, Lawrence A ,  ZHAO, Chen ,  WAKEFIELD, Brian D

CPC classification number: A61K31/506 ,  A61K31/417 ,  A61K31/496 ,  A61K45/06

Abstract: This invention discloses a method of treating pain by administering histamine H 4 receptor ligands and compositions comprising the same.

Abstract translation: 本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。

公开(公告)号：WO2005110410A2

公开(公告)日：2005-11-24

申请号：PCT/US2005/016903

申请日：2005-05-13

Applicant: ABBOTT LABORATORIES ,  CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

Inventor： CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

IPC: A61K31/4743

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  Y02A50/481

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

公开(公告)号：WO2011156698A2

公开(公告)日：2011-12-15

申请号：PCT/US2011/039958

申请日：2011-06-10

Applicant: ABBOTT LABORATORIES ,  WOLLER, Kevin R. ,  CURTIN, Michael L. ,  FRANK, Kristine E. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  WISHART, Neil

Inventor： WOLLER, Kevin R. ,  CURTIN, Michael L. ,  FRANK, Kristine E. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  WISHART, Neil

IPC: A61K31/519 ,  C07D487/04 ,  A61P35/00 ,  A61P29/00 ,  A61P11/06 ,  A61P1/00 ,  A61P17/06 ,  A61P19/02

CPC classification number: C07D487/04

Abstract: The present disclosure is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

Abstract translation: 本公开涉及新的式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如类风湿性关节炎，系统性红斑狼疮，多发性硬化症，克罗恩病 疾病，牛皮癣和哮喘。

公开(公告)号：WO2009152133A1

公开(公告)日：2009-12-17

申请号：PCT/US2009/046714

申请日：2009-06-09

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC: A01N43/42

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。