公开(公告)号：WO2007084728A3

公开(公告)日：2007-07-26

申请号：PCT/US2007/001548

申请日：2007-01-19

Applicant: ABBOTT LABORATORIES ,  ROTH, Gregory P. ,  WALLACE, Grier A. ,  GEORGE, Dawn M. ,  GRONGSAARD, Pintipa ,  HAYES, Martin ,  BREINLINGER, Eric C.

Inventor： ROTH, Gregory P. ,  WALLACE, Grier A. ,  GEORGE, Dawn M. ,  GRONGSAARD, Pintipa ,  HAYES, Martin ,  BREINLINGER, Eric C.

IPC: A61K31/496

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I), wherein the substituents are as defined herein, which are useful as therapeutic agents.

公开(公告)号：WO2009025854A1

公开(公告)日：2009-02-26

申请号：PCT/US2008/010000

申请日：2008-08-22

Applicant: BURNHAM INSTITUTE FOR MEDICAL RESEARCH ,  WOLF, Dieter, A. ,  ROTH, Gregory, P.

Inventor： WOLF, Dieter, A. ,  ROTH, Gregory, P.

IPC: G01N33/53

CPC classification number: G01N33/5011 ,  G01N2333/4739

Abstract: Methods are provided for screening for SMIPs (small molecule inhibitors of p 27 depletion). The SMIPs thus identified are useful for treating cancers and other proliferative diseases.

Abstract translation: 提供了筛选SMIPs（p27耗尽的小分子抑制剂）的方法。 如此确定的SMIPs可用于治疗癌症和其他增殖性疾病。

公开(公告)号：WO2007084728A2

公开(公告)日：2007-07-26

申请号：PCT/US2007001548

申请日：2007-01-19

Applicant: ABBOTT LAB ,  ROTH GREGORY P ,  WALLACE GRIER A ,  GEORGE DAWN M ,  GRONGSAARD PINTIPA ,  HAYES MARTIN ,  BREINLINGER ERIC C

Inventor： ROTH GREGORY P ,  WALLACE GRIER A ,  GEORGE DAWN M ,  GRONGSAARD PINTIPA ,  HAYES MARTIN ,  BREINLINGER ERIC C

IPC: A61K31/4184

CPC classification number: C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I), wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前药和其生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：WO2005110410A3

公开(公告)日：2007-03-29

申请号：PCT/US2005016903

申请日：2005-05-13

Applicant: ABBOTT LAB ,  CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  WISHART NEIL ,  YU ZHENGTIAN

Inventor： CUSACK KEVIN ,  SALMERON-GARCIA JOSE-ANDRES ,  GORDON THOMAS D ,  BARBERIS CLAUDE E ,  ALLEN HAMISH J ,  BISCHOFF AGNIESZKA K ,  ERICSSON ANNA M ,  FRIEDMAN MICHAEL M ,  GEORGE DAWN M ,  ROTH GREGORY P ,  TALANIAN ROBERT V ,  THOMAS CHRISTINE ,  WALLACE GRIER A ,  WISHART NEIL ,  YU ZHENGTIAN

IPC: C07D471/02 ,  A61K31/4743 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

公开(公告)号：WO2005110410A2

公开(公告)日：2005-11-24

申请号：PCT/US2005/016903

申请日：2005-05-13

Applicant: ABBOTT LABORATORIES ,  CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

Inventor： CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

IPC: A61K31/4743

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  Y02A50/481

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。