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公开(公告)号：EP0977587B1
公开(公告)日：2005-06-15
申请号：EP98910103.5
申请日：1998-03-02
Applicant: Acambis Inc. , ST. LOUIS UNIVERSITY
Inventor： CHAMBERS, Thomas, J. , MONATH, Thomas, P. , GUIRAKHOO, Farshad
IPC: A61K39/12 , A61K39/193 , C12N7/01
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
Abstract: A chimeric live, infectious, attenuated virus, containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that function
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公开(公告)号：EP0977587A1
公开(公告)日：2000-02-09
申请号：EP98910103.5
申请日：1998-03-02
Applicant: ORAVAX, INC. , ST. LOUIS UNIVERSITY
Inventor： CHAMBERS, Thomas, J. , MONATH, Thomas, P. , GUIRAKHOO, Farshad
IPC: A61K39/12 , A61K39/193 , C12N7/01
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
Abstract: A chimeric live, infectious, attenuated virus, containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that function
Abstract translation: 含有黄热病毒的嵌合活的感染性减毒病毒，其中prM-E蛋白的核苷酸序列被缺失，截短或突变，从而功能性prM-E蛋白不被表达，并被整合到 黄热病病毒的基因组，编码第二种不同黄病毒的prM-E蛋白的核苷酸序列，从而表达第二黄病毒的prM-E蛋白。
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公开(公告)号：WO2008094674A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/001330
申请日：2008-01-31
Applicant: ACAMBIS INC. , DELAGRAVE, Simon , BROWN, Nathan , KLEANTHOUS, Harold , GUIRAKHOO, Farshad , RUMYANTSEV, Alexander, A.
Inventor： DELAGRAVE, Simon , BROWN, Nathan , KLEANTHOUS, Harold , GUIRAKHOO, Farshad , RUMYANTSEV, Alexander, A.
IPC: A61K39/12
CPC classification number: C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/16134 , C12N2770/24143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
Abstract: This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.
Abstract translation: 本发明涉及双顺反子黄病毒载体，在预防和治疗疾病中使用这些载体的方法，以及制备此类载体的方法。
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公开(公告)号：WO2006116182A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015241
申请日：2006-04-24
Applicant: ACAMBIS INC. , PUGACHEV, Konstantin, V. , GUIRAKHOO, Farshad , MONATH, Thomas, P.
Inventor： PUGACHEV, Konstantin, V. , GUIRAKHOO, Farshad , MONATH, Thomas, P.
CPC classification number: C12N7/00 , C07K14/005 , C12N2710/16234 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
Abstract translation: 本发明提供可用于预防和治疗黄病毒感染的重组黄病毒疫苗。 本发明的疫苗含有重组黄病毒，包括减毒突变。
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公开(公告)号：WO2005082020A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/005949
申请日：2005-02-28
Applicant: ACAMBIS INC. , MONATH, Thomas, P. , GUIRAKHOO, Farshad , ARROYO, Juan , PUGACHEV, Konstantin
Inventor： MONATH, Thomas, P. , GUIRAKHOO, Farshad , ARROYO, Juan , PUGACHEV, Konstantin
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , C12N2770/24164 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
Abstract: The invention provides attenuated flavivirus vaccines and methods of making and using these vaccines.
Abstract translation: 本发明提供了减毒黄病毒疫苗以及制备和使用这些疫苗的方法。
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Patent Agency Ranking
公开(公告)号：WO2003103571A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/001214
申请日：2003-01-15
Applicant: ACAMBIS, INC. , MONATH, Thomas, P. , GUIRAKHOO, Farshad , ARROYO, Juan , PUGACHEV, Konstantin
Inventor： MONATH, Thomas, P. , GUIRAKHOO, Farshad , ARROYO, Juan , PUGACHEV, Konstantin
IPC: A61K
CPC classification number: A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
Abstract translation: 本发明提供黄病毒疫苗和制备和使用这些疫苗的方法。
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公开(公告)号：WO2003060088A3
公开(公告)日：2003-07-24
申请号：PCT/US2003/001319
申请日：2003-01-15
Applicant: ACAMBIS, INC. , MONATH, Thomas, P. , GUIRAKHOO, Farshad , ARROYO, Juan
Inventor： MONATH, Thomas, P. , GUIRAKHOO, Farshad , ARROYO, Juan
IPC: A61K39/12
Abstract: The invention provides methods for producing live, attenuated viral vaccines, such as flavivirus vaccines.
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公开(公告)号：WO2008115314A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/001309
申请日：2008-01-31
Applicant: ACAMBIS INC. , DELAGRAVE, Simon , GUIRAKHOO, Farshad , MAIER, Caroline , RUMYANTSEV, Alexander, A.
Inventor： DELAGRAVE, Simon , GUIRAKHOO, Farshad , MAIER, Caroline , RUMYANTSEV, Alexander, A.
IPC: A61K39/12
CPC classification number: A61K39/145 , A61K39/12 , A61K2039/5256 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , C12N2770/24143 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
Abstract: This invention relates to chimeric flavivirus vectors that can be used, for example, in the prevention and treatment of influenza virus infection, compositions including such viral vectors, and methods employing the vectors
Abstract translation: 本发明涉及可用于例如预防和治疗流感病毒感染的嵌合黄病毒载体，包括这种病毒载体的组合物，以及使用载体的方法
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公开(公告)号：EP1874346A1
公开(公告)日：2008-01-09
申请号：EP06751075.0
申请日：2006-04-24
Applicant: Acambis, Inc.
Inventor： PUGACHEV, Konstantin, V. , GUIRAKHOO, Farshad , MONATH, Thomas, P.
CPC classification number: C12N7/00 , C07K14/005 , C12N2710/16234 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
Abstract: The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
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公开(公告)号：EP1471873A2
公开(公告)日：2004-11-03
申请号：EP03748884.8
申请日：2003-01-15
Applicant: Acambis, Inc.
Inventor： MONATH, Thomas, P. , GUIRAKHOO, Farshad , ARROYO, Juan , PUGACHEV, Konstantin
IPC: A61K6/00
CPC classification number: A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
Abstract: The invention provides flavivirus vaccines and methods of making and using these vaccines.
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