公开(公告)号：WO2019028382A1

公开(公告)日：2019-02-07

申请号：PCT/US2018/045212

申请日：2018-08-03

Applicant: AMGEN INC.

Inventor： ACHMATOWICZ, Michal ,  ROMANINI, Dante ,  FALSEY, James R. ,  HERBERICH, Bradley J. ,  THIEL, Oliver R.

IPC: A61K47/68 ,  C07K16/00 ,  C07K14/605

Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.

公开(公告)号：EP4464719A3

公开(公告)日：2025-03-05

申请号：EP24203972.5

申请日：2018-08-03

Applicant: Amgen Inc.

Inventor： ACHMATOWICZ, Michal ,  ROMANINI, Dante ,  FALSEY, James R. ,  HERBERICH, Bradley J. ,  THIEL, Oliver R.

IPC: A61K47/68 ,  C07K16/00 ,  C07K14/605 ,  C07K16/28

Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.

公开(公告)号：EP4464719A2

公开(公告)日：2024-11-20

申请号：EP24203972.5

申请日：2018-08-03

Applicant: Amgen Inc.

Inventor： ACHMATOWICZ, Michal ,  ROMANINI, Dante ,  FALSEY, James R. ,  HERBERICH, Bradley J. ,  THIEL, Oliver R.

IPC: C07K14/605

Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.