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1.发明申请
公开(公告)号：WO2022109242A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/060048
申请日：2021-11-19
Applicant: AMGEN INC.
Inventor： ACHMATOWICZ, Michal , COYLER, John T. , CORBETT, Michael T. , GRIFFIN, Daniel J. , PARSONS, Andrew T. , ROBINSON, Joanna , QUASDORF, Kyle
IPC: C07D471/04
Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3‑isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropy1-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes [Insert Structure] (Compound A).
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公开(公告)号：WO2019028382A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/045212
申请日：2018-08-03
Applicant: AMGEN INC.
Inventor： ACHMATOWICZ, Michal , ROMANINI, Dante , FALSEY, James R. , HERBERICH, Bradley J. , THIEL, Oliver R.
IPC: A61K47/68 , C07K16/00 , C07K14/605
Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.
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公开(公告)号：EP4464719A2
公开(公告)日：2024-11-20
申请号：EP24203972.5
申请日：2018-08-03
Applicant: Amgen Inc.
Inventor： ACHMATOWICZ, Michal , ROMANINI, Dante , FALSEY, James R. , HERBERICH, Bradley J. , THIEL, Oliver R.
IPC: C07K14/605
Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.
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Patent Agency Ranking
公开(公告)号：EP4464719A3
公开(公告)日：2025-03-05
申请号：EP24203972.5
申请日：2018-08-03
Applicant: Amgen Inc.
Inventor： ACHMATOWICZ, Michal , ROMANINI, Dante , FALSEY, James R. , HERBERICH, Bradley J. , THIEL, Oliver R.
IPC: A61K47/68 , C07K16/00 , C07K14/605 , C07K16/28
Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.
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5.发明公开
公开(公告)号：EP4247813A1
公开(公告)日：2023-09-27
申请号：EP21827309.2
申请日：2021-11-19
Applicant: Amgen, Inc
Inventor： ACHMATOWICZ, Michal , COYLER, John T. , CORBETT, Michael T. , GRIFFIN, Daniel J. , PARSONS, Andrew T. , ROBINSON, Joanna , QUASDORF, Kyle
IPC: C07D471/04
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公开(公告)号：EP4472985A1
公开(公告)日：2024-12-11
申请号：EP23718377.7
申请日：2023-02-03
Applicant: Amgen Inc.
Inventor： KELLY, Ron, C. , CHAVES, Mary , TENG, Jing , PARENT, Stephan , LUU, Van , FARRELL, Robert, P. , HUCKLE, James, E. , ACHMATOWICZ, Michal , WU, Tian , REID, Darren, L , XIAO, Lingyun
IPC: C07D519/00 , A61P35/00 , A61K31/553
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公开(公告)号：EP4472984A1
公开(公告)日：2024-12-11
申请号：EP23710498.9
申请日：2023-02-03
Applicant: Amgen Inc.
Inventor： KELLY, Ron, C. , CHAVES, Mary , TENG, Jing , PARENT, Stephan , STEC, Markian , LUU, Van , FARRELL, Robert, P. , HUCKLE, James, E. , ACHMATOWICZ, Michal , WU, Tian , REID, Darren, L. , XIAO, Lingyun
IPC: C07D519/00 , A61K31/553 , A61P35/00
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公开(公告)号：EP4126883A1
公开(公告)日：2023-02-08
申请号：EP21720126.8
申请日：2021-03-30
Applicant: Amgen Inc.
Inventor： ACHMATOWICZ, Michal , CUI, Sheng , HWANG, Tsang-Lin , LANGILLE, Neil Fred , TOM, Janine K. , HUCKLE, James E. , STEC, Markian , WU, Tian , BROWN, Sean P.
IPC: C07D519/00 , A61P35/00 , A61K31/553
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