公开(公告)号：WO2004058305A3

公开(公告)日：2004-07-15

申请号：PCT/CA2003/002008

申请日：2003-12-24

Applicant: AN-GO-GEN INC. ,  STEWART, Duncan, J. ,  COURTMAN, David ,  KAROUBI, Golnaz

Inventor： STEWART, Duncan, J. ,  COURTMAN, David ,  KAROUBI, Golnaz

IPC: C12N11/04

Abstract: Cell therapy comprises encapsulating a cell with an integrin or other cell interaction factor, for administration to a mammal. The cells may express a therapeutic transgene or the cells may be regenerative.

公开(公告)号：EP1220679B1

公开(公告)日：2007-06-13

申请号：EP99944205.6

申请日：1999-09-23

Applicant: An-Go-Gen Inc.

Inventor： STEWART, Duncan, J.

IPC: A61K35/36 ,  A61K48/00 ,  C12N5/10

CPC classification number: A61K38/44 ,  A61K35/36 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/52 ,  C12Y114/13039

Abstract: Cell-based gene transfer is effected by administering transfected fibroblast cells, from dermal or other origins, containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where the cells express and secrete expression products of the transgene to act locally at the site of expression, and in some cases to be conveyed by the patient's circulation to other body organs. The process is especially useful in treatment of pulmonary hypertension by means of expressed angiogenic factors.

公开(公告)号：EP1220679A1

公开(公告)日：2002-07-10

申请号：EP99944205.6

申请日：1999-09-23

Applicant: An-Go-Gen Inc.

Inventor： STEWART, Duncan, J.

IPC: A61K35/36 ,  A61K48/00 ,  C12N5/10

CPC classification number: A61K38/44 ,  A61K35/36 ,  A61K38/1866 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/52 ,  C12Y114/13039

Abstract: Cell-based gene transfer is effected by administering transfected fibroblast cells, from dermal or other origins, containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where the cells express and secrete expression products of the transgene to act locally at the site of expression, and in some cases to be conveyed by the patient's circulation to other body organs. The process is especially useful in treatment of pulmonary hypertension by means of expressed angiogenic factors.