公开(公告)号：WO2010022076A1

公开(公告)日：2010-02-25

申请号：PCT/US2009/054193

申请日：2009-08-18

Applicant: ARRAY BIOPHARMA INC. ,  ALLEN, Shelley ,  CELESTE, Laura L. ,  DAVIS, T. Gregg ,  DELISLE, Robert Kirk ,  GRESCHUK, Julie Marie ,  GROSS, Stefan, D. ,  HICKEN, Erik, James ,  JACKSON, Leila, J. ,  LYSSIKATOS, Joseph, P. ,  KALLAN, Nicholas C. ,  MARMSATER, Fredrik, P. ,  MUNSON, Mark, C. ,  PHENEGER, Jed ,  RAST, Bryson ,  ROBINSON, John, E. ,  SCHLACHTER, Stephen T. ,  TOPALOV, George T. ,  WRIGHT, A. Dale ,  ZHAO, Qian

Inventor： ALLEN, Shelley ,  CELESTE, Laura L. ,  DAVIS, T. Gregg ,  DELISLE, Robert Kirk ,  GRESCHUK, Julie Marie ,  GROSS, Stefan, D. ,  HICKEN, Erik, James ,  JACKSON, Leila, J. ,  LYSSIKATOS, Joseph, P. ,  KALLAN, Nicholas C. ,  MARMSATER, Fredrik, P. ,  MUNSON, Mark, C. ,  PHENEGER, Jed ,  RAST, Bryson ,  ROBINSON, John, E. ,  SCHLACHTER, Stephen T. ,  TOPALOV, George T. ,  WRIGHT, A. Dale ,  ZHAO, Qian

IPC: C07D471/04 ,  A61K31/47

CPC classification number: C07D471/04

Abstract: Compounds of Formula (I), in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

Abstract translation: 其中A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有本说明书中给出的含义的式（I）化合物是可用于治疗免疫细胞相关的受体酪氨酸抑制剂 疾病和病症，如炎性和自身免疫性疾病。

公开(公告)号：EP2334677B1

公开(公告)日：2013-10-09

申请号：EP09791625.8

申请日：2009-08-18

Applicant: Array Biopharma, Inc.

Inventor： ALLEN, Shelley ,  CELESTE, Laura L. ,  DAVIS, T. Gregg ,  DELISLE, Robert Kirk ,  GRESCHUK, Julie Marie ,  GROSS, Stefan, D. ,  HICKEN, Erik, James ,  JACKSON, Leila, J. ,  LYSSIKATOS, Joseph, P. ,  KALLAN, Nicholas C. ,  MARMSATER, Fredrik, P. ,  MUNSON, Mark, C. ,  PHENEGER, Jed ,  RAST, Bryson ,  ROBINSON, John, E. ,  SCHLACHTER, Stephen T. ,  TOPALOV, George T. ,  WRIGHT, A. Dale ,  ZHAO, Qian

IPC: C07D471/04 ,  A61K31/47

CPC classification number: C07D471/04

公开(公告)号：EP2334677A1

公开(公告)日：2011-06-22

申请号：EP09791625.8

申请日：2009-08-18

Applicant: Array Biopharma, Inc.

Inventor： ALLEN, Shelley ,  CELESTE, Laura L. ,  DAVIS, T. Gregg ,  DELISLE, Robert Kirk ,  GRESCHUK, Julie Marie ,  GROSS, Stefan, D. ,  HICKEN, Erik, James ,  JACKSON, Leila, J. ,  LYSSIKATOS, Joseph, P. ,  KALLAN, Nicholas C. ,  MARMSATER, Fredrik, P. ,  MUNSON, Mark, C. ,  PHENEGER, Jed ,  RAST, Bryson ,  ROBINSON, John, E. ,  SCHLACHTER, Stephen T. ,  TOPALOV, George T. ,  WRIGHT, A. Dale ,  ZHAO, Qian

IPC: C07D471/04 ,  A61K31/47

CPC classification number: C07D471/04

Abstract: Compounds of Formula (I), in which A, B, R
1 , R
1a , R
2 , R
3 , R
4 , R
5 , R
6 , and R
7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

Abstract translation: 其中A，B，R 1，R 1a，R 2，R 3，R 4，R 5，R 6和R 7具有说明书中给出的含义的式（I）化合物是有用的受体酪氨酸抑制剂 用于治疗免疫细胞相关疾病和病症，例如炎性和自身免疫性疾病。