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公开(公告)号：WO2006119146A1
公开(公告)日：2006-11-09
申请号：PCT/US2006/016526
申请日：2006-05-01
Applicant: ARRAY BIOPHARMA INC. , HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk
IPC: C07D417/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白，特别是KSP的抑制剂，以及生产这些抑制剂的方法。 本发明还提供了包含本发明抑制剂的药物组合物以及使用该抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：WO2007130743A3
公开(公告)日：2007-11-15
申请号：PCT/US2007/063884
申请日：2007-03-13
Applicant: ARRAY BIOPHARMA, INC. , LYSSIKATOS, Joseph P. , WENGLOWSKY, Steven Mark , HENNINGS, D. David , WATSON, Daniel John
Inventor： LYSSIKATOS, Joseph P. , WENGLOWSKY, Steven Mark , HENNINGS, D. David , WATSON, Daniel John
Abstract: The present invention relates to phenylurea derivatives of capreomycin I, IIB, IIA, or IB, and metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present invention are useful as antibacterial agents for treating bacterial infections and for treating disorders caused by bacterial infections. The present invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial infections by administering such compounds. The present invention also relates to methods of preparing such compounds.
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公开(公告)号：WO2010022081A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054198
申请日：2009-08-18
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , DELISLE, Robert Kirk , GRESCHUK, Julie Marie , HICKEN, Erik James , LYSSIKATOS, Joseph P. , MARMSATER, Fredrik P. , MUNSON, Mark C. , ROBINSON, John E. , ZHAO, Qian
Inventor： ALLEN, Shelley , DELISLE, Robert Kirk , GRESCHUK, Julie Marie , HICKEN, Erik James , LYSSIKATOS, Joseph P. , MARMSATER, Fredrik P. , MUNSON, Mark C. , ROBINSON, John E. , ZHAO, Qian
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I): I in which B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 10 and R 11 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
Abstract translation: 式（I）的化合物：其中B，R1，R1a，R2，R3，R4，R5，R6，R7，R10和R11具有本说明书中给出的含义的I是可用于治疗疾病介导的受体酪氨酸抑制剂 通过PIM-1和/或PIM-2和/或PIM-3激酶。
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公开(公告)号：WO2008028141A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/077411
申请日：2007-08-31
Applicant: ARRAY BIOPHARMA INC. , BUCKMELTER, Alexandre J. , LYSSIKATOS, Joseph P. , MIKNIS, Greg , REN, Li , WENGLOWSKY, Steven Mark
Inventor： BUCKMELTER, Alexandre J. , LYSSIKATOS, Joseph P. , MIKNIS, Greg , REN, Li , WENGLOWSKY, Steven Mark
IPC: C07D491/04 , A61K31/4741 , A61P35/00
Abstract: Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：WO2007027855A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/033976
申请日：2006-08-31
Applicant: ARRAY BIOPHARMA INC. , MIKNIS, Greg , LYSSIKATOS, Joseph P. , LAIRD, Ellen , TARLTON, Eugene , BUCKMELTER, Alexandre J. , REN, Li , RAST, Bryson , SCHLACTER, Stephen T. , WENGLOWSKY, Steven Mark
Inventor： MIKNIS, Greg , LYSSIKATOS, Joseph P. , LAIRD, Ellen , TARLTON, Eugene , BUCKMELTER, Alexandre J. , REN, Li , RAST, Bryson , SCHLACTER, Stephen T. , WENGLOWSKY, Steven Mark
CPC classification number: C07D491/04 , C07D495/04
Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。 使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐的方法用于在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些疾病。 披露。
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Patent Agency Ranking
公开(公告)号：EP1879886A1
公开(公告)日：2008-01-23
申请号：EP06758821.0
申请日：2006-05-01
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk , VOEGTLI, Walter Charles
IPC: C07D417/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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7.发明公开MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权MITOTISCHE KINESINHEMMER UND VERFAHREN ZU IHRER VERWENDUNG
公开(公告)号：EP1809280A2
公开(公告)日：2007-07-25
申请号：EP05819172.7
申请日：2005-10-18
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , LYSSIKATOS, Joseph P. , AICHER, Tom , LAIRD, Ellen , ROBINSON, John , ALLEN, Shelley
IPC: A61K31/4245 , C07D417/00 , C07D413/00
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：EP2663555B1
公开(公告)日：2016-12-14
申请号：EP12733896.0
申请日：2012-01-12
Applicant: VentiRx Pharmaceuticals, Inc. , Array Biopharma, Inc.
Inventor： HOWBERT, James, Jeffry , HERSHBERG, Robert , BURGESS, Laurence E. , DOHERTY, George A. , EARY, Charles Todd , GRONEBERG, Robert D. , JONES, Zachary , LYSSIKATOS, Joseph P. , YANG, Hong Woon
IPC: A61K31/55 , A61P37/00 , C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
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公开(公告)号：EP1809280B1
公开(公告)日：2011-09-07
申请号：EP05819172.7
申请日：2005-10-18
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , LYSSIKATOS, Joseph P. , AICHER, Tom , LAIRD, Ellen , ROBINSON, John , ALLEN, Shelley
IPC: A61K31/4245 , C07D417/00 , C07D413/00
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：EP1879886B1
公开(公告)日：2014-07-09
申请号：EP06758821.0
申请日：2006-05-01
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk , VOEGTLI, Walter Charles
IPC: C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
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