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1.发明授权SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1, 2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS CFMS INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并+ AFS-1，2-A + AF0 - 吡啶-3-甲酰胺作为抑制剂CFMS
公开(公告)号：EP2516433B1
公开(公告)日：2014-05-21
申请号：EP10798683.8
申请日：2010-12-20
Applicant: Array Biopharma, Inc.
Inventor： BOYS, Mark Laurence , BRADLEY, Michael F. , DELISLE, Robert Kirk , HENNINGS, D. David , KENNEDY, April L. , MARMSATER, Fredrik P. , MEDINA, Matthew David , MUNSON, Mark C. , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC: C07D471/04 , C07D519/00 , A61K31/437 , A61K31/4985 , A61P9/00 , A61P19/08 , A61P29/00 , A61P35/00
CPC classification number: C07D471/04 , C07D519/00
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2.发明公开SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1, 2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS CFMS INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并+ AFS-1，2-A + AF0 - 吡啶-3-甲酰胺作为抑制剂CFMS
公开(公告)号：EP2516433A1
公开(公告)日：2012-10-31
申请号：EP10798683.8
申请日：2010-12-20
Applicant: Array Biopharma, Inc.
Inventor： BOYS, Mark Laurence , BRADLEY, Michael F. , DELISLE, Robert Kirk , HENNINGS, D. David , KENNEDY, April L. , MARMSATER, Fredrik P. , MEDINA, Matthew David , MUNSON, Mark C. , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC: C07D471/04 , C07D519/00 , A61K31/437 , A61K31/4985 , A61P9/00 , A61P19/08 , A61P29/00 , A61P35/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R
1 , R
2 , R
3 , R
4 and R
5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.
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