公开(公告)号：WO2013055645A1

公开(公告)日：2013-04-18

申请号：PCT/US2012/059282

申请日：2012-10-09

Applicant: ARRAY BIOPHARMA INC. ,  BOYS, Mark Laurence ,  BURGESS, Laurence E. ,  EARY, C. Todd ,  GRONEBERG, Robert ,  HACHE, Bruno P. ,  HARVEY, Darren ,  HICKEN, Erik James ,  KRASER, Christopher F. ,  LAIRD, Ellen ,  MORENO, David A. ,  MUNSON, Mark C. ,  REN, Li ,  ROBINSON, John E. ,  SCHLACHTER, Stephen T.

Inventor： BOYS, Mark Laurence ,  BURGESS, Laurence E. ,  EARY, C. Todd ,  GRONEBERG, Robert ,  HACHE, Bruno P. ,  HARVEY, Darren ,  HICKEN, Erik James ,  KRASER, Christopher F. ,  LAIRD, Ellen ,  MORENO, David A. ,  MUNSON, Mark C. ,  REN, Li ,  ROBINSON, John E. ,  SCHLACHTER, Stephen T.

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

CPC classification number: C07D487/04

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 and X 2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract translation: R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有本说明书中给出的含义的式I化合物及其立体异构体及其药学上可接受的盐和溶剂合物是一种或多种JAK激酶的抑制剂，并且是有用的 治疗自身免疫性疾病，炎症性疾病，移植器官，组织和细胞排斥，以及血液系统疾病和恶性肿瘤及其并发症。

公开(公告)号：WO2007089646A1

公开(公告)日：2007-08-09

申请号：PCT/US2007/002272

申请日：2007-01-26

Applicant: ARRAY BIOPHARMA INC. ,  GRONEBERG, Robert ,  BURGESS, Laurence, E. ,  HARVEY, Darren ,  LAIRD, Ellen ,  MUNSON, Mark ,  RIZZI, James ,  RODRIGUEZ, Martha ,  EARY, Charles, Todd ,  WATSON, Daniel

Inventor： GRONEBERG, Robert ,  BURGESS, Laurence, E. ,  HARVEY, Darren ,  LAIRD, Ellen ,  MUNSON, Mark ,  RIZZI, James ,  RODRIGUEZ, Martha ,  EARY, Charles, Todd ,  WATSON, Daniel

IPC: C07D231/40 ,  C07D231/56 ,  A61K31/416 ,  A61P29/00

CPC classification number: C07D231/40 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

Abstract translation: 式（I）化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。

公开(公告)号：WO2004078116A3

公开(公告)日：2004-09-16

申请号：PCT/US2004/005693

申请日：2004-02-25

Applicant: ARRAY BIOPHARMA, INC. ,  MUNSON, Mark ,  MARESKA, David, A. ,  KIM, Youngboo ,  GRONEBERG, Robert ,  RIZZI, James ,  RODRIGUEZ, Martha ,  KIM, Ganghyeok ,  VIGERS, Guy ,  RAO, Chang ,  BALACHARI, Devan ,  HARVEY, Darren

Inventor： MUNSON, Mark ,  MARESKA, David, A. ,  KIM, Youngboo ,  GRONEBERG, Robert ,  RIZZI, James ,  RODRIGUEZ, Martha ,  KIM, Ganghyeok ,  VIGERS, Guy ,  RAO, Chang ,  BALACHARI, Devan ,  HARVEY, Darren

IPC: A61K31/4745 ,  A61K31/503 ,  A61K31/675 ,  C07D401/14 ,  C07D471/02 ,  C07D487/02

Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.

公开(公告)号：EP1606283B1

公开(公告)日：2008-10-08

申请号：EP04714621.2

申请日：2004-02-25

Applicant: Array Biopharma, Inc.

Inventor： MUNSON, Mark ,  MARESKA, David, A. ,  KIM, Youngboo ,  GRONEBERG, Robert ,  RIZZI, James ,  RODRIGUEZ, Martha ,  KIM, Ganghyeok ,  VIGERS, Guy ,  RAO, Chang ,  BALACHARI, Devan ,  HARVEY, Darren

IPC: C07D401/14 ,  C07D471/04 ,  C07D231/56 ,  C07D261/20 ,  C07D403/04 ,  C07D413/12 ,  A61K31/416 ,  A61K31/4162 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D231/56 ,  C07D261/20 ,  C07D413/12

Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.

公开(公告)号：EP1981851B1

公开(公告)日：2012-01-25

申请号：EP07762713.1

申请日：2007-01-26

Applicant: Array Biopharma, Inc.

Inventor： GRONEBERG, Robert ,  BURGESS, Laurence, E. ,  HARVEY, Darren ,  LAIRD, Ellen ,  MUNSON, Mark ,  RIZZI, James ,  RODRIGUEZ, Martha ,  EARY, Charles, Todd ,  WATSON, Daniel

IPC: C07D231/40 ,  C07D231/56 ,  A61K31/416 ,  A61P29/00

CPC classification number: C07D231/40 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

公开(公告)号：EP1981851A1

公开(公告)日：2008-10-22

申请号：EP07762713.1

申请日：2007-01-26

Applicant: Array Biopharma, Inc. ,  Groneberg, Robert ,  Burgess, Laurence E. ,  Harvey, Darren ,  Laird, Ellen ,  Munson, Mark ,  Rizzi, James ,  Rodriguez, Martha ,  Eary, Charles Todd ,  Watson, Daniel

Inventor： GRONEBERG, Robert ,  BURGESS, Laurence, E. ,  HARVEY, Darren ,  LAIRD, Ellen ,  MUNSON, Mark ,  RIZZI, James ,  RODRIGUEZ, Martha ,  EARY, Charles, Todd ,  WATSON, Daniel

IPC: C07D231/40 ,  C07D231/56 ,  A61K31/416 ,  A61P29/00

CPC classification number: C07D231/40 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

公开(公告)号：EP2766368A1

公开(公告)日：2014-08-20

申请号：EP12775905.8

申请日：2012-10-09

Applicant: Array Biopharma Inc.

Inventor： BOYS, Mark Laurence ,  BURGESS, Laurence E. ,  EARY, C. Todd ,  GRONEBERG, Robert ,  HACHE, Bruno P. ,  HARVEY, Darren ,  HICKEN, Erik James ,  KRASER, Christopher F. ,  LAIRD, Ellen ,  MORENO, David A. ,  MUNSON, Mark C. ,  REN, Li ,  ROBINSON, John E. ,  SCHLACHTER, Stephen T.

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

CPC classification number: C07D487/04

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , X
1 and X
2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract translation: 其中R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有说明书中给出的含义的式I化合物及其立体异构体和药学上可接受的盐和溶剂合物是 一种或多种JAK激酶，并且可用于治疗自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液病和恶性肿瘤及其并发症。

公开(公告)号：EP1606283A2

公开(公告)日：2005-12-21

申请号：EP04714621.2

申请日：2004-02-25

Applicant: Array Biopharma, Inc.

Inventor： MUNSON, Mark ,  MARESKA, David, A. ,  KIM, Youngboo ,  GRONEBERG, Robert ,  RIZZI, James ,  RODRIGUEZ, Martha ,  KIM, Ganghyeok ,  VIGERS, Guy ,  RAO, Chang ,  BALACHARI, Devan ,  HARVEY, Darren

IPC: C07D401/14

CPC classification number: C07D471/04 ,  C07D231/56 ,  C07D261/20 ,  C07D413/12

Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.