公开(公告)号：BG63941B1

公开(公告)日：2003-07-31

申请号：BG10254798

申请日：1998-06-17

Applicant: BALKANFARMA DUPNITSA AD

Inventor： STANEVA TINKA D ,  LAZOV VLADIMIR K ,  STANEV STANCHO R ,  DIMITROVA-BACHEVA BOJKA L ,  BOTSEVA ADELINA V ,  KAFEDZHIJSKI STEFAN K

IPC: C07D211/10 ,  C07D211/30 ,  C07D211/74

Abstract: The 2,2,6,6-tetramethyl-4-oxopiperidine p-toluenesulphonate is used in medicine as antidepressive and antineurotic means. By the method p-toluenesulphonic salts of 2,2,6,6-tetramethyl-4-oxopiperidine, also known as triacetonamine is produced at high yields and purity in a reduced and simplified process in catalytic condensation of acetone with ammonia. The reaction occurs at temperature range from -15 to +15 degrees C at continuous agitation and slow acetone saturation with gaseous ammonia, until a ratio between them of 1.5:1 to 1:1.5 is achieved. In the addition to the acetonine-containing reaction medium of additional catalyst quantities and 0.1-1 ml siccative, the acetonine is converted into triacetonamine. The triacetonamine produced, without being isolated from the reaction mixture, is settled as a salt at the addition of p-toluenesulphonic acid. 5 claims

公开(公告)号：BG102547A

公开(公告)日：2000-04-28

申请号：BG10254798

申请日：1998-06-17

Applicant: BALKANFARMA DUPNITSA AD

Inventor： STANEVA TINKA D ,  LAZOV VLADIMIR K ,  STANEV STANCHO R ,  DIMITROVA-BACHEVA BOJKA L ,  BOTSEVA ADELINA V ,  KAFEDZHIJSKI STEFAN K

IPC: C07D211/10 ,  C07D211/30 ,  C07D211/74 ,  A61K31/445

Abstract: The invention relates to a method for the preparation of 2,2,6,6-tetramethyl-4-oxopiperidine p-toluenesulphonate showing antidepression and antineurotic effect. The compound has the general formula The method consists of consecutive production of triacetonamine from acetone and gaseous ammonia. Additional quantity of acetone and a catalyst is added and the compound becomes 2,2,6,6-tetramethyl-4-oxopiperidine which, without being isolated, settles as a salt of the p-toluenesulphonic acid. 4 claims