公开(公告)号：BG103281A

公开(公告)日：2000-11-30

申请号：BG10328199

申请日：1999-03-25

Applicant: BALKANFARMA DUPNITSA AD

Inventor： PETKOV VLADIMIR J ,  STANEV STANCHO R ,  MILENKOV STRASHIMIR V ,  BOJCHEVA SNEZHANA A ,  NIKOLOVA EVELINA B ,  ANTOV VALERI D ,  KARKOVA AGNESA M ,  DEKOV NIKOLA G ,  RADEVA DIANA S ,  VELEVA JULIJA TS ,  JORDANOVA ADRIANA K ,  BASHIKAROVA ANTOANETA K ,  KONSTANTINOVA RUMJANA G ,  ELENSKA MAJA I ,  MITSEV GEORGI K ,  PEJCHEVA NATALIJA D ,  DIMANOVA RADOST G

IPC: C07D201/00 ,  C07D215/10

Abstract: The method has greater efficacy. By it a product is turned out of high yield and purity, particularly suitable for the preparation of inoculation forms. The method consists of reductive aminoethylation of aqueous solution of glucose and excess of aqueous solution of ethylamine with hydrogen at pressure ranging from 30 to 15 at. and temperature range of 40 to 50 deg. C in the presence of skeleton nickel catalyst. After the closure of the process the catalyst is separated from the reaction mixture which is treated with activated carbon at temperatures from 50 to 55 deg. C and is flitered. Immediately after that the reaction aqueous mixture is subjected to crystallization in stages being initially cooled down to 25-30 deg. C with agitation for about 2 to 5 h, after which the temperature is reduced to 0-2 deg. C and the mixture rests with no agitation for 1-2 h under these conditions. The N-ethylglucamine cristallizes with a high yield and purity. 1 claims

公开(公告)号：BG63941B1

公开(公告)日：2003-07-31

申请号：BG10254798

申请日：1998-06-17

Applicant: BALKANFARMA DUPNITSA AD

Inventor： STANEVA TINKA D ,  LAZOV VLADIMIR K ,  STANEV STANCHO R ,  DIMITROVA-BACHEVA BOJKA L ,  BOTSEVA ADELINA V ,  KAFEDZHIJSKI STEFAN K

IPC: C07D211/10 ,  C07D211/30 ,  C07D211/74

Abstract: The 2,2,6,6-tetramethyl-4-oxopiperidine p-toluenesulphonate is used in medicine as antidepressive and antineurotic means. By the method p-toluenesulphonic salts of 2,2,6,6-tetramethyl-4-oxopiperidine, also known as triacetonamine is produced at high yields and purity in a reduced and simplified process in catalytic condensation of acetone with ammonia. The reaction occurs at temperature range from -15 to +15 degrees C at continuous agitation and slow acetone saturation with gaseous ammonia, until a ratio between them of 1.5:1 to 1:1.5 is achieved. In the addition to the acetonine-containing reaction medium of additional catalyst quantities and 0.1-1 ml siccative, the acetonine is converted into triacetonamine. The triacetonamine produced, without being isolated from the reaction mixture, is settled as a salt at the addition of p-toluenesulphonic acid. 5 claims

公开(公告)号：BG63080B1

公开(公告)日：2001-03-30

申请号：BG10328199

申请日：1999-03-25

Applicant: BALKANFARMA DUPNITSA AD

Inventor： PETKOV VLADIMIR J ,  STANEV STANCHO R ,  MILENKOV STRASHIMIR V ,  BOJCHEVA SNEZHANA A ,  NIKOLOVA EVELINA B ,  ANTOV VALERI D ,  KARKOVA AGNESA M ,  DEKOV NIKOLA G ,  RADEVA DIANA S ,  VELEVA JULIJA TS ,  JORDANOVA ADRIANA K ,  BASHIKAROVA ANTOANETA K ,  KONSTANTINOVA RUMJANA G ,  ELENSKA-ZHELJAZKOVA MAJA I ,  MITSEV GEORGI K ,  PEJCHEVA NATALIJA D ,  DIMANOVA RADOST G

IPC: C07D201/00 ,  C07D215/10

Abstract: The method has greater efficacy. By it a product is turned out of high yield and purity, particularly suitable for the preparation of inoculation forms. The method consists of reductive aminoethylation of aqueous solution of glucose and excess of aqueous solution of ethylamine with hydrogen at pressure ranging from 30 to 15 at. and temperature range of 40 to 50 deg. C in the presence of skeleton nickel catalyst. After the closure of the process the catalyst is separated from the reaction mixture which is treated with activated carbon at temperatures from 50 to 55 deg. C and is flitered. Immediately after that the reaction aqueous mixture is subjected to crystallization in stages being initially cooled down to 25-30 deg. C with agitation for about 2 to 5 h, after which the temperature is reduced to 0-2 deg. C and the mixture rests with no agitation for 1-2 h under these conditions. The N-ethylglucamine cristallizes with a high yield and purity. 1 claim

公开(公告)号：BG105640A

公开(公告)日：2003-01-31

申请号：BG10564001

申请日：2001-06-22

Applicant: BALKANFARMA DUPNITSA AD

Inventor： STANEVA TINKA D ,  KAFEDZHIJSKI STEFAN K ,  NACHEVA ELIZABETA B ,  PARALANOVA DANIELA I ,  STANEV STANCHO R ,  KATSARSKI DIMITAR E

IPC: C07C255/49

Abstract: The method is used in the pharmaceutical industry for the production of 4-hydroxy-3-iodo-5-nitrobenzonitrile, known by its generic name of Nitroxynil, which is used in the veterinary pharmaceutical practice for the treatment of helminthic infections. The compound has high yield and purity and is produced by the method of nitration of 4-hydroxybenzonitrile with water solution of sodium or ammonium nitrate, in saline-acidic medium at 80 degrees C and continuous agitation. The 4-hydroxy-5-netrobenzonitrile produced is iodized at 80 to 110 degrees C, after which the reaction mixture is cooled to 10-15 degrees C. The precipitation of 4-hydroxy-3-iodo-5-benzonitrile is filtered, rinsed in water, re-crystallized in ethanol and is dried. 3 claims

公开(公告)号：BG102547A

公开(公告)日：2000-04-28

申请号：BG10254798

申请日：1998-06-17

Applicant: BALKANFARMA DUPNITSA AD

Inventor： STANEVA TINKA D ,  LAZOV VLADIMIR K ,  STANEV STANCHO R ,  DIMITROVA-BACHEVA BOJKA L ,  BOTSEVA ADELINA V ,  KAFEDZHIJSKI STEFAN K

IPC: C07D211/10 ,  C07D211/30 ,  C07D211/74 ,  A61K31/445

Abstract: The invention relates to a method for the preparation of 2,2,6,6-tetramethyl-4-oxopiperidine p-toluenesulphonate showing antidepression and antineurotic effect. The compound has the general formula The method consists of consecutive production of triacetonamine from acetone and gaseous ammonia. Additional quantity of acetone and a catalyst is added and the compound becomes 2,2,6,6-tetramethyl-4-oxopiperidine which, without being isolated, settles as a salt of the p-toluenesulphonic acid. 4 claims