公开(公告)号：BG103281A

公开(公告)日：2000-11-30

申请号：BG10328199

申请日：1999-03-25

Applicant: BALKANFARMA DUPNITSA AD

Inventor： PETKOV VLADIMIR J ,  STANEV STANCHO R ,  MILENKOV STRASHIMIR V ,  BOJCHEVA SNEZHANA A ,  NIKOLOVA EVELINA B ,  ANTOV VALERI D ,  KARKOVA AGNESA M ,  DEKOV NIKOLA G ,  RADEVA DIANA S ,  VELEVA JULIJA TS ,  JORDANOVA ADRIANA K ,  BASHIKAROVA ANTOANETA K ,  KONSTANTINOVA RUMJANA G ,  ELENSKA MAJA I ,  MITSEV GEORGI K ,  PEJCHEVA NATALIJA D ,  DIMANOVA RADOST G

IPC: C07D201/00 ,  C07D215/10

Abstract: The method has greater efficacy. By it a product is turned out of high yield and purity, particularly suitable for the preparation of inoculation forms. The method consists of reductive aminoethylation of aqueous solution of glucose and excess of aqueous solution of ethylamine with hydrogen at pressure ranging from 30 to 15 at. and temperature range of 40 to 50 deg. C in the presence of skeleton nickel catalyst. After the closure of the process the catalyst is separated from the reaction mixture which is treated with activated carbon at temperatures from 50 to 55 deg. C and is flitered. Immediately after that the reaction aqueous mixture is subjected to crystallization in stages being initially cooled down to 25-30 deg. C with agitation for about 2 to 5 h, after which the temperature is reduced to 0-2 deg. C and the mixture rests with no agitation for 1-2 h under these conditions. The N-ethylglucamine cristallizes with a high yield and purity. 1 claims

公开(公告)号：BG63080B1

公开(公告)日：2001-03-30

申请号：BG10328199

申请日：1999-03-25

Applicant: BALKANFARMA DUPNITSA AD

Inventor： PETKOV VLADIMIR J ,  STANEV STANCHO R ,  MILENKOV STRASHIMIR V ,  BOJCHEVA SNEZHANA A ,  NIKOLOVA EVELINA B ,  ANTOV VALERI D ,  KARKOVA AGNESA M ,  DEKOV NIKOLA G ,  RADEVA DIANA S ,  VELEVA JULIJA TS ,  JORDANOVA ADRIANA K ,  BASHIKAROVA ANTOANETA K ,  KONSTANTINOVA RUMJANA G ,  ELENSKA-ZHELJAZKOVA MAJA I ,  MITSEV GEORGI K ,  PEJCHEVA NATALIJA D ,  DIMANOVA RADOST G

IPC: C07D201/00 ,  C07D215/10

Abstract: The method has greater efficacy. By it a product is turned out of high yield and purity, particularly suitable for the preparation of inoculation forms. The method consists of reductive aminoethylation of aqueous solution of glucose and excess of aqueous solution of ethylamine with hydrogen at pressure ranging from 30 to 15 at. and temperature range of 40 to 50 deg. C in the presence of skeleton nickel catalyst. After the closure of the process the catalyst is separated from the reaction mixture which is treated with activated carbon at temperatures from 50 to 55 deg. C and is flitered. Immediately after that the reaction aqueous mixture is subjected to crystallization in stages being initially cooled down to 25-30 deg. C with agitation for about 2 to 5 h, after which the temperature is reduced to 0-2 deg. C and the mixture rests with no agitation for 1-2 h under these conditions. The N-ethylglucamine cristallizes with a high yield and purity. 1 claim