公开(公告)号：RU2163808C2

公开(公告)日：2001-03-10

申请号：RU96121628

申请日：1995-03-23

Applicant: BASF AG

Inventor： EHRNST BAUMANN ,  UVE JOZEF FOGEL BAKHER ,  JOAKHIM RAJNKHAJMER ,  DAGMAR KLINGE ,  KHARTMUT RIKHERS ,  BURKKHARD KREGER ,  ZIGFRID BIALOJAN ,  KLAUS BOLL SHVAJLER ,  VOL FGANG VERNET ,  LILIANE UNGER ,  MANFRED RASHAK

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  C07D251/26 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: organic chemistry, pharmacy. SUBSTANCE: invention proposes a novel drug showing inhibitory properties with respect to endothelin receptors. Invention proposes derivatives of carboxylic acid of the general formula (I): where R means formyl group, carboxyl group or residue easily hydrolyzed to carboxyl group; R2 and R3 means alkoxyl with carbon atoms number from 1 to 4; X means nitrogen atom or the group CH; R4,R5 and R6 means as given in the invention claim; Y means sulfur or oxygen atom; Z means oxygen atom. EFFECT: broadened arsenal of agents of indicated prescription. 4 tbl, 10 ex