公开(公告)号：RU2163808C2

公开(公告)日：2001-03-10

申请号：RU96121628

申请日：1995-03-23

Applicant: BASF AG

Inventor： EHRNST BAUMANN ,  UVE JOZEF FOGEL BAKHER ,  JOAKHIM RAJNKHAJMER ,  DAGMAR KLINGE ,  KHARTMUT RIKHERS ,  BURKKHARD KREGER ,  ZIGFRID BIALOJAN ,  KLAUS BOLL SHVAJLER ,  VOL FGANG VERNET ,  LILIANE UNGER ,  MANFRED RASHAK

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  C07D251/26 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: organic chemistry, pharmacy. SUBSTANCE: invention proposes a novel drug showing inhibitory properties with respect to endothelin receptors. Invention proposes derivatives of carboxylic acid of the general formula (I): where R means formyl group, carboxyl group or residue easily hydrolyzed to carboxyl group; R2 and R3 means alkoxyl with carbon atoms number from 1 to 4; X means nitrogen atom or the group CH; R4,R5 and R6 means as given in the invention claim; Y means sulfur or oxygen atom; Z means oxygen atom. EFFECT: broadened arsenal of agents of indicated prescription. 4 tbl, 10 ex

公开(公告)号：RU2146255C1

公开(公告)日：2000-03-10

申请号：RU95120095

申请日：1994-04-13

Applicant: BASF AG

Inventor： EHRNST BAUMANN ,  AL BREKHT KHARREUS ,  MATTIAS BRATS ,  JOAKHIM RAJNKHAJMER ,  UVEH JOZEF FOGEL BAKHER ,  GANS TEOBAL D ,  MATTIAS GERBER ,  GEL MUT VAL TER ,  KARL-OTTO VESTFALEN ,  VIL GEL M RADEMAKHER

IPC: C07D233/64 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/653 ,  A01N43/66 ,  A01N43/713 ,  A01N43/76 ,  A01N43/80 ,  A01P13/00 ,  C07D207/333 ,  C07D207/335 ,  C07D213/55 ,  C07D231/12 ,  C07D239/34 ,  C07D239/38 ,  C07D239/56 ,  C07D239/60 ,  C07D261/08 ,  C07D263/32 ,  C07D275/02 ,  C07D277/14 ,  C07D307/28 ,  C07D333/16 ,  C07D333/24 ,  C07D333/28 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/048

Abstract: FIELD: agriculture. SUBSTANCE: described are 3-halogen-3-hetarylcarboxylic acid derivatives of formula I: wherein R is -C(O)R1 wherein R1 is C1-C4 alkoxy group or -OR9 wherein R9 is hydrogen or alkali metal cation; R2 and R3 is C1-C4 alkoxy group; X is CR13 wherein R13 is hydrogen; R4 is fine-or six-membered heteroaromatic ring containing one or two nitrogen atoms and/or one sulfur atom or one oxygen atom which contains one or several residues from among C1-C4-alkyl, or phenyl; R5 is hydrogen or C1-C4-alkyl; Y is sulfur or oxygen; Z is halogen, and herbicidal agent based thereon. Said compounds have herbicidal activity. EFFECT: improved properties of the title compounds. 5 cl, 5 ex, 9 tbl

公开(公告)号：RU2135479C1

公开(公告)日：1999-08-27

申请号：RU95120096

申请日：1994-04-14

Applicant: BASF AG

Inventor： EHRNST BAUMANN ,  JOAKHIM RAJNKHAJMER ,  UVEH JOZEF FOGEL BAKHER ,  MATTIAS BRATS ,  NORBERT MEJER ,  MATTIAS GERBER ,  KARL-OTTO VESTFALEN ,  GEL MUT VAL TER ,  VIL GEL M RADEMAKHER

IPC: C07D251/34 ,  A01N43/54 ,  A01N43/60 ,  A01N43/66 ,  A01P13/00 ,  C07C69/22 ,  C07C69/712 ,  C07C69/734 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/52 ,  C07D239/60 ,  C07D251/30 ,  C07D307/46 ,  C07D307/54 ,  C07D333/24 ,  C07D405/12 ,  C07D409/12 ,  C07D491/048

Abstract: FIELD: agriculture. SUBSTANCE: 3-aryloxycarboxylic acid derivatives of general formula I wherein R is radical OR wherein R is hydrogen, C 1 -C 4 alkyl, alkali metal cation, equivalent of alkaline-earth metal cation, ammonium cation or organic ammonium cation; R 2 and R are C 1 -C 4 alkoxy group; X is CH; R is phenyl which is substituted by 1-5 halogen atoms and/or 1-3 groups selected from C 1 -C 4 alkyl and C 1 -C 4 alkoxy group; R is C-C alkyl or phenyl; R is phenyl which is substituted by one or more substituents selected from group consisting of halogen, hydroxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy group, C 1 -C 4 alkylthio group or acetoxy group; Y is sulfur or oxygen; Z is oxygen, have herbicidal or bioregulating activity. Herbicidal agent and agent for controlling growth of plants based on compounds of formula I are described. EFFECT: compounds having improved selective activity and higher biological effectiveness. 8 cl, 5 ex, 7 tbl

公开(公告)号：RU2180335C2

公开(公告)日：2002-03-10

申请号：RU97107617

申请日：1995-10-07

Applicant: BASF AG

Inventor： KHARTMUT RIKHERS ,  DAGMAR KLINGE ,  VIL KHEL M AMBERG ,  ANDREAS KLING ,  SHTEFAN MJULLER ,  EHRNST BAUMANN ,  JOAKHIM RAJNKHAJMER ,  UVE JOZEF FOGEL BAKHER ,  VOL FGANG VERNET ,  LILIANE UNGER ,  MANFRED RASHAK

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048

Abstract: organic synthesis. SUBSTANCE: invention provides novel carboxylic acid derivatives having general formula I: (I) and containing heterocyclic moieties. Compound possess biological activity, in particular they inhibit binding of endothelin to receptors and can be used for treatment of hypertension, myocardial infarction, renal insufficiency, and other maladies. In the formula I, (i) R1 denotes tetrazole, nitrile, carboxylic group, group COOR7, in which R7 is C1-C4-alkyl or alkali of alkaliearth cation, group -CONHSO2R8, in which R8 is C1-C4-alkyl, or group -CONHSO2R9, in which R9 is C1-C4-alkyl; (ii) R2 denotes hydroxy group, amino group, di-C1-C4- alkylaino group, or C1-C4-alkoxy group; (iii) X denotes nitrogen or radical CR10, in which R10 is hydrogen or C1-C5- alkyl, or CR10 and CR3 together form 5- or 6-membered alkylene or alkenylene ring optionally substituted by 1 or 2 C1- C4-alkyl group and in which one methylene group can be substituted by oxygen, imino or C1-C4-imino group; (iv) R3 denotes mono- or di-C1-C4-alkyl group, C1- C4-alkyl, C1-C4-alkoxy, or CR3 together with CR10 form above-described ring; (v) R4 and R5 each denote phenyl optionally substituted by halogen, C1-C4-alkyl or C1-C4-alkoxy, provided that two phenyls are in ortho-position to each other and linked by an ordinary linkage, methylene or ethylene group, or C3- C7- cycloalkyl group; (vi) R6 denotes C1-C8-alkyl or C3-C6-alkenyl optionally substituted by halogen, cyano, C1-C4- alkoxy, C1-C4-alkylthio, or phenyl; phenyl optionally substituted by one or two groups selected from halogen, C1-C4- alkyl, C1-C4-alkoxyl; cycloalkyl optionally substituted by C1-C4-alkyl; or five- or six-membered heterocyclic residue containing one sulfur or oxygen atom and optionally substituted by C1-C4-alkyl; and (vii) Z denotes sulfur, oxygen, sulfinyl or sulfonyl. EFFECT: extended choice of drugs. 3 tbl, 25 ex

公开(公告)号：RU2140413C1

公开(公告)日：1999-10-27

申请号：RU95120099

申请日：1994-04-13

Applicant: BASF AG

Inventor： EHRNST BAUMANN ,  JOAKHIM RAJNKHAJMER ,  UVEH JOZEF FOGEL BAKHER ,  MATTIAS BRATS ,  GANS TEOBAL D ,  MATTIAS GERBER ,  KARL-OTTO VESTFALEN ,  GEL MUT VAL TER ,  VIL GEL M RADEMAKHER

IPC: A01N43/54 ,  A01N43/64 ,  A01N43/66 ,  A01N43/72 ,  A01P13/00 ,  A01P21/00 ,  C07C45/58 ,  C07C47/198 ,  C07C47/277 ,  C07C59/125 ,  C07C67/31 ,  C07C69/708 ,  C07C69/734 ,  C07C205/28 ,  C07C323/22 ,  C07C323/50 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D251/22 ,  C07D239/60 ,  C07D251/24 ,  C07D251/30 ,  C07D251/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D411/12 ,  C07D413/12 ,  C07D477/12 ,  C07D491/048 ,  A01N43/34 ,  A01N43/06

Abstract: FIELD: agriculture. SUBSTANCE: described are new 3-(het) arylcarboxylic acid derivatives of general formula I: R, R 2 -R 6 , Z, Y, X wherein are as defined in claim 1, which show herbicidal activity. Also described are herbicidal agent based on compounds of formula I and agent for controlling growth of plants. EFFECT: improved properties of the herbicidal agent and the plant growth control agent. 8 cl, 5 ex, 8 tbl