公开(公告)号：DE19642591A1

公开(公告)日：1998-04-16

申请号：DE19642591

申请日：1996-10-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  MOELLER ACHIM DR ,  DELZER JUERGEN DR

IPC: A61K31/445 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/5355 ,  A61P9/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D211/62 ,  C07D213/40 ,  C07D295/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14

Abstract: Disclosed are piperidine-keto acid derivates of general formula (I) and their tautomeric and isomeric forms, as well as their physiologically well tolerated salts, where R can mean -CO-R , -SO -R , -CONH-R , -COOR , -C(=N)-R , -C(=O)-NHR and -C(=S)-NHR ; R can have the meaning -C1-C6-alkyl, whether branched or not, and can still carry a phenyl, a pyridine or a naphthyl-ring, which can possibly be substituted with no more than two R residues, while R C1-C4-alkyl, whether branched or not, can mean -O-C1-C4-alkyl, OH, Cl, F, Br, J, CF3, NO2, NH2, CN, COOH, COO-C1-C4-alkyl, -NHCO-C1-C4-alkyl, -NHCOPh, -NHSO2-C1-C4-alkyl, NHSO2-Ph, -SO2-C1-C4-alkyl and -SO2Ph; and R can mean -OR and -NHR . The preparation of the inventive compounds and their use as drug products are also disclosed.