公开(公告)号：DE3782549D1

公开(公告)日：1992-12-17

申请号：DE3782549

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

Abstract: (I) and their allelic variations and mutagenically produced derivs. with lymphotoxin or lymphotoxin-like activity, as well as derivs. having an N-terminal immunogenic peptide sequence, are new. (I) is X-Leu-Lys-Pro-Ala-Ala-His-Leu-Ile -Gly-Asp-Pro-Ser-Lys-Gln-Asn-Ser-Leu- Leu-Trp-Arg-Ala-Asn-Thr-Asp-Arg-Ala-Phe-Leu-Gln-Asp-Gly-Phe-Ser-L- eu-Ser-Asn-Asn-Ser-Leu-Leu -Val-Pro-Thr-Ser-Gly-Ile -Tyr-Phe-Val-Tyr-Ser-Gln- -Val-Val-Phe-Ser-Gly-Lys-Ala-Tyr-Ser-Pro-Lys-Ala-Thr- Ser-Ser-Pro-Leu Tyr-Leu-Ala-His-Glu-Val -Gln- Leu-Phe-Ser--Ser-Gln-Tyr-Pro-Phe-His-Val-Pro- Leu-Leu-Ser-Ser-Gln -Lys-Met-Val-Tyr-Pro-Gly- Leu-Gln-Glu-Pro -Trp-Leu-His-Ser-Met-Tyr-His-Gly -Ala-Ala-Phe-Gln-Leu-Thr-Gln-Gly-Asp- Gln-Leu-Ser-Thr -His-Thr-Asp-Gly-Ile-Pro-His-Leu -Val-Leu-Ser-Pro Ser-Thr-Val-Phe-Phe-Gly -Ala-Phe-Ala-Leu, where X = Thr, Ser-Thr, Met-Ser-Thr, Ala-Thr or Ala-Ser-Thr. DNA sequences coding for the polypeptides are also new.

公开(公告)号：DE3922089A1

公开(公告)日：1990-12-13

申请号：DE3922089

申请日：1989-07-05

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG DR ,  HILLEN HEINZ DR ,  MOELLER ACHIM DR ,  DAUM LOTHAR DR ,  DOERPER THOMAS DR ,  SUBKOWSKI THOMAS DR

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: Novel proteins have a molecular weight of approximately 42.000 daltons and the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu on their terminal N, where X denotes a hydrogen atom, a phenylalanine (Phe) residue or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe. These proteins have a therapeutic effect.

公开(公告)号：DE3716513A1

公开(公告)日：1988-11-24

申请号：DE3716513

申请日：1987-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS DR ,  MOELLER ACHIM DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  KEILHAUER GERHARD DR ,  EMLING FRANZ DR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  C07H21/04

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：DE19650975A1

公开(公告)日：1998-06-10

申请号：DE19650975

申请日：1996-12-09

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  MOELLER ACHIM DR ,  TREIBER HANS-JOERG DR

IPC: A61K31/403 ,  A61K31/4035 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D209/48 ,  C07D209/66 ,  C07D239/70 ,  C07D239/96 ,  C07D401/12 ,  C07D471/04 ,  C07D475/02 ,  C07D235/26 ,  C07D235/02 ,  C07D217/24 ,  C07D209/64 ,  C07D275/06 ,  C07D403/12 ,  A61K31/40 ,  A61K31/505

Abstract: The invention concerns heterocyclically substituted benzamides of formula (I) in which R , R , R , R , R , X, m and n have the meanings given in the description. The novel compounds are suitable for fighting diseases.

公开(公告)号：ES2058083T3

公开(公告)日：1994-11-01

申请号：ES87113278

申请日：1987-09-11

Applicant: BASF AG

Inventor： MOELLER ACHIM DR ,  EMLING FRANZ DR

IPC: G01N33/53 ,  A61K39/395 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07H21/04 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C07K14/525 ,  C07K16/00 ,  C07K16/24 ,  C12N5/10 ,  C12N5/20 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

Abstract: The monoclonal antibodies are directed highly specifically against human tumour necrosis factor and are synthesised by hybridoma cell lines prepared as described. … …

公开(公告)号：DE3787241D1

公开(公告)日：1993-10-07

申请号：DE3787241

申请日：1987-09-11

Applicant: BASF AG

Inventor： MOELLER ACHIM DR ,  EMLING FRANZ DR

IPC: G01N33/53 ,  A61K39/395 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07H21/04 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C07K14/525 ,  C07K16/00 ,  C07K16/24 ,  C12N5/10 ,  C12N5/20 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

Abstract: The monoclonal antibodies are directed highly specifically against human tumour necrosis factor and are synthesised by hybridoma cell lines prepared as described. … …

公开(公告)号：CZ20003891A3

公开(公告)日：2001-03-14

申请号：CZ20003891

申请日：1999-04-20

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  MOELLER ACHIM DR ,  TREIBER HANS-JOERG DR ,  KNOPP MONIKA DR

IPC: A61K31/44 ,  A61K31/455 ,  A61K31/495 ,  A61K31/505 ,  A61P25/28 ,  C07D213/82 ,  C07D215/50 ,  C07D239/42 ,  C07D295/155 ,  C07D317/60 ,  C07D401/04 ,  C07D405/12

公开(公告)号：DE19642591A1

公开(公告)日：1998-04-16

申请号：DE19642591

申请日：1996-10-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  MOELLER ACHIM DR ,  DELZER JUERGEN DR

IPC: A61K31/445 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/5355 ,  A61P9/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D211/62 ,  C07D213/40 ,  C07D295/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14

Abstract: Disclosed are piperidine-keto acid derivates of general formula (I) and their tautomeric and isomeric forms, as well as their physiologically well tolerated salts, where R can mean -CO-R , -SO -R , -CONH-R , -COOR , -C(=N)-R , -C(=O)-NHR and -C(=S)-NHR ; R can have the meaning -C1-C6-alkyl, whether branched or not, and can still carry a phenyl, a pyridine or a naphthyl-ring, which can possibly be substituted with no more than two R residues, while R C1-C4-alkyl, whether branched or not, can mean -O-C1-C4-alkyl, OH, Cl, F, Br, J, CF3, NO2, NH2, CN, COOH, COO-C1-C4-alkyl, -NHCO-C1-C4-alkyl, -NHCOPh, -NHSO2-C1-C4-alkyl, NHSO2-Ph, -SO2-C1-C4-alkyl and -SO2Ph; and R can mean -OR and -NHR . The preparation of the inventive compounds and their use as drug products are also disclosed.

公开(公告)号：AT93895T

公开(公告)日：1993-09-15

申请号：AT87113278

申请日：1987-09-11

Applicant: BASF AG

Inventor： MOELLER ACHIM DR ,  EMLING FRANZ DR

IPC: A61K39/395 ,  C12N15/00 ,  C12P21/00 ,  G01N33/577

公开(公告)号：AT82329T

公开(公告)日：1992-11-15

申请号：AT87108847

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00