公开(公告)号：WO0185165A2

公开(公告)日：2001-11-15

申请号：PCT/EP0105359

申请日：2001-05-10

Applicant: BASF AG ,  HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  MUELLER WALTER E ,  ECKERT GUENTHER P

Inventor： HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  MUELLER WALTER E ,  ECKERT GUENTHER P

IPC: C07D339/04 ,  A61K31/385 ,  A61K31/519 ,  A61K31/7076 ,  A61K45/00 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  C07D475/04 ,  C07H19/16

CPC classification number: A61K31/385 ,  A61K31/519 ,  A61K31/7076 ,  A61K2300/00

Abstract: The invention relates to the use of lipoic acid and C1 donors, especially S-adenosylmethionine and/or 5-methyltetrahydrofolate, for treating disorders of the central nervous system. The invention also relates to agents containing a corresponding active substance combination and to agents in the form of commercial packages containing the inventive combination preparations or monopreparations for combined use.

Abstract translation: 本发明涉及使用的硫辛酸和C1-供体，特别是S-腺苷甲硫氨酸和/或5-甲基，对中枢神经系统的障碍的治疗，与相应的活性成分组合装置，并与相应的组合产品或单一成分的产品的商业包装形式的组合物用于组合 应用。

公开(公告)号：DE10022856A1

公开(公告)日：2001-11-15

申请号：DE10022856

申请日：2000-05-10

Applicant: BASF AG

Inventor： HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  MUELLER WALTER ,  ECKERT GUENTHER P

IPC: A61K31/385 ,  A61K31/519 ,  C07D339/04 ,  A61K31/7076 ,  A61K45/00 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  C07D475/04 ,  C07H19/16 ,  A61K31/381

Abstract: The use of lipoic acid (I) (or its derivative or salt) is claimed for the preparation of a medicament for the C1 donor (II)-supported treatment of central nervous system disorders; and the use of (II) is claimed for the preparation of a medicament for the (I)-supported treatment of central nervous system disorders. Independent claims are included for the following: (i) a composition containing (I) (or its salt or derivative), (II), optionally further active agents and a formulation base; and (ii) a commercial package including at least one composition containing (I) (or its salt or derivative) and/or (II), together with instructions for the therapeutic use of (I) in combination with (II).

公开(公告)号：ZA200209940B

公开(公告)日：2003-12-09

申请号：ZA200209940

申请日：2002-12-09

Applicant: BASF AG

Inventor： ECKERT GUENTHER P ,  HASSELWANDER OLIVER ,  HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  MUELLER WALTER E

IPC: A61K31/385 ,  A61K31/519 ,  C07D339/04 ,  A61K31/7076 ,  A61K45/00 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  C07D475/04 ,  C07H19/16 ,  A61K ,  A61P

Abstract: The present invention relates to the use of lipoic acid and C1 donors, in particular S-adenosylmethionine and/or 5-methyltetrahydrofolate, for the treatment of central nervous system disorders, to compositions with a corresponding active ingredient combination and to compositions in the form of commercial packs with corresponding combination products or single component products for combined use.