公开(公告)号：WO0184962A3

公开(公告)日：2002-04-11

申请号：PCT/EP0104984

申请日：2001-05-03

Applicant: BASF AG ,  HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  SCHWEIKERT LONI

Inventor： HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  SCHWEIKERT LONI

IPC: A23L1/30 ,  A23C9/158 ,  A23K1/16 ,  A23L1/29 ,  A23L1/302 ,  A23L1/305 ,  A23L2/52 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/7076 ,  A61K31/714 ,  A61P9/00 ,  A61P25/00 ,  C07D475/04

CPC classification number: A23K20/10 ,  A23C9/158 ,  A23K20/174 ,  A23L2/52 ,  A23L33/15 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  C07D475/04 ,  A23V2250/5486 ,  A23V2250/716 ,  A23V2250/5482 ,  A23V2250/628 ,  A23V2250/616 ,  A23V2250/1578 ,  A23V2250/70 ,  A23V2250/702 ,  A23V2250/708 ,  A23V2250/71 ,  A23V2250/704 ,  A23V2250/032 ,  A23V2250/211

Abstract: Compositions containing folic acid in combination with 5-methyltetrahydrofolic acid are disclosed, as well as compositions containing folic acid, 5-methyltetrahydrofolic acid and/or 5-methyltetrahydrofolic acid polyglutamate and a dietary component and/or a dietary preparation and the use thereof.

Abstract translation: 含叶酸的组合物，提出了结合5-甲基四氢叶酸，以及含有叶酸，5-甲基四氢叶酸和/或5-Methyltetrahydrofolsäurepolyglutamat组合物和食品成分和/或含有它们和它们的用途的营养制剂。

公开(公告)号：WO0185165A2

公开(公告)日：2001-11-15

申请号：PCT/EP0105359

申请日：2001-05-10

Applicant: BASF AG ,  HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  MUELLER WALTER E ,  ECKERT GUENTHER P

Inventor： HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  MUELLER WALTER E ,  ECKERT GUENTHER P

IPC: C07D339/04 ,  A61K31/385 ,  A61K31/519 ,  A61K31/7076 ,  A61K45/00 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  C07D475/04 ,  C07H19/16

CPC classification number: A61K31/385 ,  A61K31/519 ,  A61K31/7076 ,  A61K2300/00

Abstract: The invention relates to the use of lipoic acid and C1 donors, especially S-adenosylmethionine and/or 5-methyltetrahydrofolate, for treating disorders of the central nervous system. The invention also relates to agents containing a corresponding active substance combination and to agents in the form of commercial packages containing the inventive combination preparations or monopreparations for combined use.

Abstract translation: 本发明涉及使用的硫辛酸和C1-供体，特别是S-腺苷甲硫氨酸和/或5-甲基，对中枢神经系统的障碍的治疗，与相应的活性成分组合装置，并与相应的组合产品或单一成分的产品的商业包装形式的组合物用于组合 应用。

公开(公告)号：GB2298137B

公开(公告)日：1999-01-06

申请号：GB9603571

申请日：1996-02-20

Applicant: BASF AG

Inventor： BIERDEL-WILLKOMMEN ELVIRA ,  SAMBALE CLEMENS ,  HAEHNLEIN WOLFGANG

IPC: A23K20/174 ,  A61K8/11 ,  A61K8/65 ,  A61K9/48 ,  C08J3/12 ,  A61J3/07

Abstract: Soft gelatin capsules consisting of capsule shell and capsule filling, where the capsule filling comprises one or more water-insoluble active ingredients) in the form of a powdered product.

公开(公告)号：ZA200209941B

公开(公告)日：2004-03-09

申请号：ZA200209941

申请日：2002-12-09

Applicant: BASF AG

Inventor： HASSELWANDER OLIVER ,  HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  SCHWEIKERT LONI

IPC: A23L1/30 ,  A23C9/158 ,  A23K1/16 ,  A23L1/305 ,  A23L2/52 ,  A23L33/00 ,  A23L33/15 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/7076 ,  A61K31/714 ,  A61P9/00 ,  A61P25/00 ,  C07D475/04 ,  A23L

Abstract: Compositions are proposed which comprise folic acid in combination with 5-methyltetrahydrofolic acid, and also compositions which comprise folic acid, 5-methyltetrahydrofolic acid and/or 5-methyltetrahydrofolylpolyglutamate and also comprise a dietary component and/or a nutrient preparation, and their use is also proposed.

公开(公告)号：DE10022510A1

公开(公告)日：2001-11-15

申请号：DE10022510

申请日：2000-05-10

Applicant: BASF AG

Inventor： HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  SCHWEIKERT LONI

IPC: A23L1/30 ,  A23C9/158 ,  A23K1/16 ,  A23L1/305 ,  A23L2/52 ,  A23L33/00 ,  A23L33/15 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/7076 ,  A61K31/714 ,  A61P9/00 ,  A61P25/00 ,  C07D475/04 ,  A61K31/525

Abstract: Composition (I) contains: (a) folic acid; (b) 5-methyl-tetrahydrofolic acid and/or 5-methyltetrahydrofolic acid polyglutamate and (c) a nutrient component and/or a nutrition preparation, provided that if (c) is a nutrient component, then the amount of (b) in the overall composition (I) is greater than that in (c). Alternatively (c) may be absent if (b) is 5-methyl-tetrahydrofolic acid.

公开(公告)号：CA2216320A1

公开(公告)日：1998-04-14

申请号：CA2216320

申请日：1997-10-10

Applicant: BASF AG

Inventor： OLESEN JES ELENIUS ,  TOBIASEN ANNE GRETHE ,  HAEHNLEIN WOLFGANG ,  HANSEN MORTEN MOHR

IPC: A23K1/16 ,  A23K20/174 ,  A23L1/00 ,  A23L33/15 ,  A61K9/107 ,  A61K9/14 ,  A61K31/07 ,  A61K31/12 ,  A61K31/122 ,  A61K31/355 ,  A61K31/59 ,  A61P3/02 ,  B01J13/00 ,  A61K31/19 ,  A23L1/302

Abstract: The present invention relates to stable emulsions and dry powders of mixtures of fat-soluble vitamins, and to processes for their preparation and to their use.

公开(公告)号：DE10022856A1

公开(公告)日：2001-11-15

申请号：DE10022856

申请日：2000-05-10

Applicant: BASF AG

Inventor： HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  HASSELWANDER OLIVER ,  MUELLER WALTER ,  ECKERT GUENTHER P

IPC: A61K31/385 ,  A61K31/519 ,  C07D339/04 ,  A61K31/7076 ,  A61K45/00 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  C07D475/04 ,  C07H19/16 ,  A61K31/381

Abstract: The use of lipoic acid (I) (or its derivative or salt) is claimed for the preparation of a medicament for the C1 donor (II)-supported treatment of central nervous system disorders; and the use of (II) is claimed for the preparation of a medicament for the (I)-supported treatment of central nervous system disorders. Independent claims are included for the following: (i) a composition containing (I) (or its salt or derivative), (II), optionally further active agents and a formulation base; and (ii) a commercial package including at least one composition containing (I) (or its salt or derivative) and/or (II), together with instructions for the therapeutic use of (I) in combination with (II).

公开(公告)号：GB2298137A

公开(公告)日：1996-08-28

申请号：GB9603571

申请日：1996-02-20

Applicant: BASF AG

Inventor： BIERDEL-WILLKOMMEN ELVIRA ,  SAMBALE CLEMENS ,  HAEHNLEIN WOLFGANG

IPC: A23K20/174 ,  A61K8/11 ,  A61K8/65 ,  A61K9/48 ,  C08J3/12 ,  A61J3/07

Abstract: Soft gelatin capsules comprise a capsule shell and a capsule filling, the capsule filling comprising one or more water-insoluble active ingredient(s) in the form of a powdered product with the particle size distribution 400 m.

公开(公告)号：DK170287D0

公开(公告)日：1987-04-03

申请号：DK170287

申请日：1987-04-03

Applicant: BASF AG

Inventor： HORN DIETER ,  QUADBECK-SEEGER HANS-JUERGEN ,  SCHAEFFER PETER ,  HAEHNLEIN WOLFGANG

IPC: A23L5/44 ,  B01J13/02 ,  C09B61/00 ,  C09B67/02 ,  C09B67/42 ,  A23L1/27

公开(公告)号：ZA200209940B

公开(公告)日：2003-12-09

申请号：ZA200209940

申请日：2002-12-09

Applicant: BASF AG

Inventor： ECKERT GUENTHER P ,  HASSELWANDER OLIVER ,  HAEHNLEIN WOLFGANG ,  KRAEMER KLAUS ,  MUELLER WALTER E

IPC: A61K31/385 ,  A61K31/519 ,  C07D339/04 ,  A61K31/7076 ,  A61K45/00 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  C07D475/04 ,  C07H19/16 ,  A61K ,  A61P

Abstract: The present invention relates to the use of lipoic acid and C1 donors, in particular S-adenosylmethionine and/or 5-methyltetrahydrofolate, for the treatment of central nervous system disorders, to compositions with a corresponding active ingredient combination and to compositions in the form of commercial packs with corresponding combination products or single component products for combined use.