PROCESS FOR PREPARING NITROIMIDAZOLE DERIVATIVES

    公开(公告)号:KR820001686B1

    公开(公告)日:1982-09-17

    申请号:KR760002570

    申请日:1976-10-15

    Applicant: BASF AG

    Abstract: Nitroimdazolyivinylthiadiazoles (I, R1 = C1-4 alkyl; R2 = H, CH3; R3 = H, C1-24 alkyl, substitutable ph, heteroallyl) useful agents for treating bacteria, fungi and protozoa, were prepd. by the reaction of 2-substituted-1,3,4-thiadiazole(II) and 5-nitroimidazole-2-carboxaldehyde(III) or its acetal at elevated temp. Thus, 2,5-dimethy 1-1,3,4-thiadiazole and 1-methyl-5-nitroimidazole-2-carboxy aldehyde were refluxed in glacial acetic acid and acetic anhydride in the presence of ZnCl2 for 10 hr and recrystallized with DMF to give -methyl-5-[2-(1-methyl-5-nitroimidazol-2-yl)-vinyl -1,3,4-thiadiazloe(m.p. 248≦̸C).

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