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公开(公告)号：WO2004022776A3
公开(公告)日：2004-07-08
申请号：PCT/EP0309369
申请日：2003-08-23
Applicant: BASF AG , FREUND ANNETTE , ROEHL FRANZ , ALTHOEFER HENNING , KAROS MARVIN , KAESLER BRUNO , LACOUR THIERRY
Inventor： FREUND ANNETTE , ROEHL FRANZ , ALTHOEFER HENNING , KAROS MARVIN , KAESLER BRUNO , LACOUR THIERRY
CPC classification number: A01N61/00 , A01N43/90 , C12N9/78 , C12Q1/34 , C12Y305/04025 , G01N2500/02
Abstract: The present invention relates to inhibition of GTP cyclohydrolase II as target for the identification of fungicides. Binding assays are claimed and coupled enzymatic assays are disclosed involving the conversion of formate (product of the reaction catalyzed by GTP-cyclohydrolases) by formate dehydrogenase and spectroscopically measuring the NADH formed. Furthermore in vivo assays with organisms containing a GTP-cyclohydrolase II are claimed as well as a DNA sequence for a fungal GTP-cyclohydrolase II. 3-Butyl-10-(3-chlorophenyl)- 10H-pyrimido[4,5-b]quinoline-2,4-dione is identified by the enzymatic method as a fungicide. Finally, methods of controlling fungi (e.g. on plants, in soil) by applying this agent are claimed.
Abstract translation: 本发明涉及抑制GTP环化水解酶II作为鉴定杀真菌剂的靶标。 公开了结合测定法，并公开了偶联的酶测定法，其涉及通过甲酸脱氢酶转化甲酸盐（由GTP-环化水解酶催化的反应产物）并光谱测量形成的NADH。 此外还要求具有含有GTP-环化水解酶II的生物体的体内测定以及用于真菌GTP-环化水解酶II的DNA序列。 通过酶法将3-丁基-10-（3-氯苯基）-10H-嘧啶并[4,5-b]喹啉-2,4-二酮鉴定为杀真菌剂。 最后，要求保护通过施用该试剂控制真菌（例如在土壤中的植物上）的方法。
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2.发明申请URIDYL GLUCOSE PYROPHOSPHORYLASE AS TARGET FOR FUNGICIDES 审中-公开URIDYL GLUCOSE PYROPHOSPHORYLASE作为目标用于杀真菌剂
公开(公告)号：WO2005005629A3
公开(公告)日：2005-02-10
申请号：PCT/EP2004007229
申请日：2004-07-02
Applicant: BASF AG , LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , LOESCH ANKE , JENCZMIONKA NICOLE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA , SCHMIDT RALF-MICHAEL
Inventor： LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , LOESCH ANKE , JENCZMIONKA NICOLE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA , SCHMIDT RALF-MICHAEL
CPC classification number: C12N9/1241 , C12Q1/48
Abstract: The present invention relates to the provision of a polypeptide with the enzymatic activity of a Uridyl glucose pyrophosphorylase as targets for fungicides, the provision of novel nucleic acid sequences encoding a polypeptide with the enzymatic activity of a Uridyl glucose pyrophosphorylase, the provision of functional equivalents of the aforementioned nucleic acid sequences, and use of a polypeptide with the enzymatic activity of a Uridyl glucose pyrophosphorylase encoded by a nucleic acid sequence in a method for identifying antifungal compounds. Furthermore, the invention relates to antifungal compounds identified by the abovementioned method and the use of these compounds as fungicides.
Abstract translation: 本发明涉及提供具有乌吡啶葡萄糖焦磷酸化酶作为杀真菌剂靶的酶活性的多肽，提供编码具有乌吡啶葡萄糖焦磷酸化酶的酶活性的多肽的新型核酸序列，提供功能等同物 上述核酸序列，以及在鉴定抗真菌化合物的方法中使用由核酸序列编码的乌吡啶葡萄糖焦磷酸化酶的酶活性的多肽。 此外，本发明涉及通过上述方法鉴定的抗真菌化合物和这些化合物作为杀真菌剂的用途。
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公开(公告)号：WO2004043150A8
公开(公告)日：2005-06-23
申请号：PCT/EP0312483
申请日：2003-11-08
Applicant: BASF AG , OAKLEY PETER , FREUND ANNETTE , SCHELBERGER KLAUS
Inventor： OAKLEY PETER , FREUND ANNETTE , SCHELBERGER KLAUS
CPC classification number: A01N57/20 , A01N61/00 , A01N47/24 , A01N2300/00
Abstract: The invention relates to a method for yield improvement in glyphosate-resistant legumes, characterised in that the plants or the seedstock are treated with a mixture comprising: a) a compound of formula (I), where X, m, Q and A have the meanings given in the description and b) a glyphosate derivative (II) in a synergistically effective amount.
Abstract translation: 一种用于在相反的抗草甘膦豆类增产，其特征在于，I（式I）其中X，M，Q，A如说明书中所定义的植物或种子与包含a）式的化合物的混合物的方法 和b）以协同有效量处理具有Glyphosatederivat II。
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公开(公告)号：WO2005054283A2
公开(公告)日：2005-06-16
申请号：PCT/EP2004013555
申请日：2004-11-30
Applicant: BASF AG , EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC , LEIN WOLFGANG , BOERNKE FREDERIK , DEIST KIRSTEN
Inventor： EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC , LEIN WOLFGANG , BOERNKE FREDERIK , DEIST KIRSTEN
IPC: C07K14/415 , C12N9/14 , C12N15/82 , C12Q1/37 , G01N33/569 , G01N33/573
CPC classification number: C12N9/14 , C12N15/8261 , C12Q1/37 , G01N33/56961 , G01N33/573 , Y02A40/146
Abstract: The present invention relates to Clp-protease, which, when absent, brings about reduced growth and chlorotic leaves as target for herbicides. For this purpose, novel nucleic acid sequences encompassing SEQ ID NO:3, SEQ ID NO:11 and SEQ ID NO: 17 and functional equivalents of SEQ ID NO:3, SEQ ID NO:11 and SEQ ID NO: 17 are provided. Moreover, the present invention relates to the use of Clp-protease in a method for identifying compounds with herbicidal or growth-regulatory activity, and to the use of the compounds identified by this method as herbicides or growth regulators.
Abstract translation: 本发明涉及Clp-蛋白酶，其在不存在时导致生长减少和褪绿叶作为除草剂的靶标。 为此目的，提供了包含SEQ ID NO：3，SEQ ID NO：11和SEQ ID NO：17的新型核酸序列和SEQ ID NO：3，SEQ ID NO：11和SEQ ID NO：17的功能等价物。 此外，本发明涉及Clp-蛋白酶在鉴定具有除草或生长调节活性的化合物的方法中的用途，以及由该方法鉴定的化合物作为除草剂或生长调节剂的用途。
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公开(公告)号：WO2005085451A3
公开(公告)日：2006-07-06
申请号：PCT/EP2005050942
申请日：2005-02-23
Applicant: BASF AG , BOERNKE FREDERIK , EHRHARDT THOMAS , FREUND ANNETTE , LEIN WOLFGANG , REINDL ANDREAS , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC
Inventor： BOERNKE FREDERIK , EHRHARDT THOMAS , FREUND ANNETTE , LEIN WOLFGANG , REINDL ANDREAS , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC
CPC classification number: C12N15/8274 , A01N61/00 , C12N9/1258 , C12Q1/48 , G01N2333/9125
Abstract: The present invention relates to polynucleotide phosphorylase (PNPase), which, when absent brings about reduced growth and chlorotic leaves, as target for herbicides. For this purpose, nucleic acid sequences encompassing SEQ. ID No. 1 and functional equivalents of SEQ.ID No. 1 are provided. Moreover, the present invention relates to the use of polynucleotide phosphorylase in a method for identifying compounds with herbicidal or growth-regulatory activity, and to the use of the compounds identified by this method as herbicides or growth regulators.
Abstract translation: 本发明涉及多核苷酸磷酸化酶（PNPase），当不存在时会导致减少的生长和褪绿叶作为除草剂的靶标。 为此目的，包含SEQ ID NO： 提供ID No.1和SEQ ID NO.1的功能等同物。 此外，本发明涉及多核苷酸磷酸化酶在鉴定具有除草或生长调节活性的化合物的方法中的用途，以及通过该方法鉴定的化合物作为除草剂或生长调节剂的用途。
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Patent Agency Ranking
公开(公告)号：WO2005047513A3
公开(公告)日：2005-08-11
申请号：PCT/EP2004052816
申请日：2004-10-27
Applicant: BASF AG , EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC , LEIN WOLFGANG , BOERNKE FREDERIK , DEIST KIRSTEN
Inventor： EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC , LEIN WOLFGANG , BOERNKE FREDERIK , DEIST KIRSTEN
CPC classification number: C12N15/8274 , C12N9/00
Abstract: The invention relates to the use of glycin decarboxylase complex, which is used as a target for herbicides in the absence of growth retardations and chlorotic leaves. Novel nucleic acid sequences comprising SEQ ID NO:1 and functional equivalents of SEQ ID NO:1 are thus disclosed. The invention also relates to the use of glycin decarboxylase complex and the functional equivalents thereof in a method for identifying compounds having a herbicidal or growth-regulatory effect, in addition to the use of said compounds identified via said method as herbicides or growth regulators.
Abstract translation: 本发明涉及甘氨酸脱羧酶复合物在不存在时引起生长迟缓以及褪绿叶作为除草剂目标的用途。 在此范围内，提供了包含SEQ ID NO：1和SEQ ID NO：1的功能等同物的新型核酸序列。 此外，本发明涉及在用于识别与除草或生长作用的化合物，以及使用由该方法作为除草剂或生长调节剂鉴定这些化合物的方法中的用途甘氨酸脱羧酶复合物和它的功能等价物的。 ，
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公开(公告)号：WO2004005522A3
公开(公告)日：2004-06-03
申请号：PCT/EP0307028
申请日：2003-07-02
Applicant: BASF AG , LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA
Inventor： LACOUR THIERRY , RETHER JAN , FREUND ANNETTE , SCHAEFER WILHELM , MAIER FRANK , MALZ SASCHA
CPC classification number: C12N15/80
Abstract: The invention relates to novel plasmid vectors for transformation of filamentous fungi and to a method of modifiying the genome of filamentous fungi based on these vectors. The invention furthermore relates to the modification of a specific gene via the process of homologous recombination, to recombinant expression of foreign genes in filamentous fungi and to new selection markers for detecting succesfull transfer of the target gene in filamentous fungi.
Abstract translation: 本发明涉及用于转化丝状真菌的新型质粒载体和基于这些载体修饰丝状真菌基因组的方法。 本发明还涉及通过同源重组的方法修饰特定基因，重组外源基因在丝状真菌中的表达，以及用于检测丝状真菌中靶基因成功转移的新选择标记。
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8.发明申请
公开(公告)号：WO0204619A2
公开(公告)日：2002-01-17
申请号：PCT/EP0107763
申请日：2001-07-06
Applicant: BASF AG , FREUND ANNETTE , SONNEWALD UWE , DING LI
Inventor： FREUND ANNETTE , SONNEWALD UWE , DING LI
IPC: A01H5/00 , A01N37/24 , A01N41/10 , A01N43/54 , A01N47/34 , A01N57/26 , C12N1/21 , C12N5/10 , C12N9/04 , C12N9/88 , C12N15/09 , C12N15/53 , C12N15/82 , C12Q1/02 , C12Q1/32 , C12Q1/527 , C12Q1/68 , C12N15/00
CPC classification number: C12N9/0006 , C12N9/88 , C12N15/8274 , C12Q1/32 , C12Q1/527 , G01N2430/20 , G01N2500/00
Abstract: The invention relates to the use of a nucleic acid sequence coding for a polypeptide exhibiting dehydroquinate dehydrase/shikimate dehydrogenase activity for producing a test system for discovering the inhibitors of dehydroquinate dehydrase/shikimate dehydrogenase. For the first time, it has been shown, with the aid of the antisense technology, that dehydroquinate dehydrase/shikimate dehydrogenase constitutes a herbicide target. The invention further relates to a method for producing transgenic plants containing a nucleic acid sequence coding for a polypeptide containing dehydroquinate dehydrase/shikimate dehydrogenase (E.C. 4.2.1.10/E.C. 1.1.1.25) activity, characterised by an increased biomass production or/and an increased content of aromatized amino acids compared to a non-transgenic plant.
Abstract translation: 本发明涉及使用编码具有用于产生测定系统用于查找脱氢脱水酶/莽草酸脱氢酶的抑制剂脱氢脱水酶/莽草酸脱氢酶活性的多肽的核酸序列。 第一次反义技术已经通过单元，其脱氢莽草酸脱水酶是脱氢酶/除草剂目标所示。 此外，与比较本申请涉及生产含编码具有脱氢脱水酶/莽草酸脱氢酶（EC 4.2.1.10/EC 1.1.1.25）活性，其特征在于增加的生物量产生和/或芳香氨基酸含量增加的多肽的核酸序列的转基因植物的 非转基因植物。
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公开(公告)号：AU2004289827A1
公开(公告)日：2005-05-26
申请号：AU2004289827
申请日：2004-10-27
Applicant: BASF AG
Inventor： NIGEL MARC STITT , BORNKE FREDERIK , REINDL ANDREAS , EHRHARDT THOMAS , SCHMIDT RALF-MICHAEL , DEIST KIRSTEN , LEIN WOLFGANG , FREUND ANNETTE , SONNEWALD UWE
Abstract: The invention relates to the use of glycine decarboxylase complex, which is used as a target for herbicides in the absence of growth retardations and chlorotic leaves. Novel nucleic acid sequences comprising SEQ ID NO:1 and functional equivalents of SEQ ID NO:1 are thus disclosed. The invention also relates to the use of glycine decarboxylase complex and the functional equivalents thereof in a method for identifying compounds having a herbicidal or growth-regulatory effect, in addition to the use of said compounds identified via said method as herbicides or growth regulators.
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公开(公告)号：AU2003293906A1
公开(公告)日：2004-07-22
申请号：AU2003293906
申请日：2003-12-17
Applicant: BASF AG , EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF MICHAEL , DEIST KIRSTEN , SONNEWALD UWE , STITT NIGEL MARC , LEIN WOLFGANG , BORNKE FREDERIK
Inventor： EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF-MICHAEL , DEIST KIRSTEN , SONNEWALD UWE , NIGEL MARC STITT , LEIN WOLFGANG , BORNKE FREDERIK
Abstract: The present invention relates to malate dehydrogenase, which, when absent, brings about reduced growth and chlorotic leaves and is encoded by the nucleic acid sequence SEQ ID NO:2 or by a functional equivalent of this nucleic acid sequence, as target for herbicides. For this purpose, novel nucleic acid sequences encompassing SEQ ID NO:2 and functional equivalents of SEQ ID NO:2 are provided. Moreover, the present invention relates to the use of the abovementioned malate dehydrogenase and its functional equivalents in a method for identifying compounds with herbicidal or growth-regulatory activity, and to the use of the compounds identified by this method as herbicides or growth regulators.
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