公开(公告)号：DE19900545A1

公开(公告)日：2000-07-13

申请号：DE19900545

申请日：1999-01-11

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  KNOPP MONIKA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVI ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14

Abstract: The invention relates to the utilization of pyrimidine derivatives of formula (I), wherein the substituents have the meaning cited in the description, and to the utilization of the physiologically compatible salts thereof for producing medicaments used for preventing and treating cerebral ischaemia and strokes.

公开(公告)号：DE19900674A1

公开(公告)日：2000-07-13

申请号：DE19900674

申请日：1999-01-11

Applicant: BASF AG

Inventor： GARCIA-LADONA FRANCISCO JAVI

IPC: G01N33/50 ,  A61K31/00 ,  A61K31/135 ,  A61K31/4045 ,  A61K31/437 ,  A61K31/48 ,  A61K31/496 ,  A61K31/506 ,  A61K45/00 ,  A61P9/00 ,  A61P25/06 ,  A61P43/00 ,  C12Q1/02 ,  C12Q1/44 ,  G01N33/15 ,  G01N33/68 ,  C12N5/00

Abstract: The invention relates to selective binding partners for 5-HT5-receptors, methods, in particular screening methods, for identifying and characterizing such binding partners, as well as pharmaceutical compositions containing said binding partners and their use in the treatment of cerebrovascular diseases such as migraine.

公开(公告)号：DE19900544A1

公开(公告)日：2000-07-13

申请号：DE19900544

申请日：1999-01-11

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVI ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/505 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.

公开(公告)号：DE19900673A1

公开(公告)日：2000-07-13

申请号：DE19900673

申请日：1999-01-11

Applicant: BASF AG

Inventor： GARCIA-LADONA FRANCISCO JAVI ,  SZABO LASZLO ,  STEINER GERD ,  HOFMANN HANS-PETER

IPC: G01N33/50 ,  A61K31/519 ,  A61K45/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P35/00 ,  C07D495/14 ,  G01N33/15 ,  G01N33/566 ,  A61K31/505 ,  C12N5/00 ,  C12Q1/02 ,  C12Q1/44

Abstract: The invention relates to the use of binding partners for 5-HT5-receptors in the treatment of neuropathological and in particular neurodegenerative and/or neuropsychiatric disturbances which can occur notably in cases of cerebral ischaemia, cerebral stroke, epilepsy and attacks in general, chronic schizophrenia, other psychotic illnesses, dementia, notably Alzheimer's disease, demyelination diseases, notably multiple sclerosis, and brain tumors. The invention also relates to methods, especially screening methods, for identifying and characterizing such binding partners.