公开(公告)号：US3920829A

公开(公告)日：1975-11-18

申请号：US28476072

申请日：1972-08-30

Applicant: BASF AG

Inventor： ROHR WOLFGANG ,  FRANKE ALBRECHT ,  GIERTZ HUBERT ,  AMANN AUGUST

IPC: A61K31/27

CPC classification number: A61K31/27

Abstract: P-aminophenol-bis-carbamate derivatives which are suitable as active ingredients in drugs, particularly for inhibiting inflammation, the production of such active ingredients, and drug formulations containing the active ingredients.

公开(公告)号：US3882141A

公开(公告)日：1975-05-06

申请号：US34530873

申请日：1973-03-27

Applicant: BASF AG

Inventor： HAGEN HELMUT ,  AMANN AUGUST ,  GIERTZ HUBERT

IPC: A61K31/55 ,  A61P9/08 ,  A61P9/10 ,  A61P25/04 ,  A61P29/00 ,  C07D233/20 ,  C07D495/10 ,  C07D513/04 ,  C07D49/34

CPC classification number: C07D495/10 ,  C07D233/20 ,  C07D513/04 ,  Y10S514/929

Abstract: Biologically active imidazolino-(1,2-d)-benzo-1,4-thiazepines, their production and their acid addition salts. These compounds, especially as the pharmacologically compatible salts, are useful to dilate coronary vessels of guinea pigs and rabbits and exhibit analgesic, spasmolytic and blood pressure changing properties.

Abstract translation: 生物活性咪唑啉 - [1,2-d] - 苯并-1,4-硫杂吗啉，它们的生产及其酸加成盐。 这些化合物，特别是作为药理学上相容的盐，可用于扩张豚鼠和兔子的冠状动脉血管并显示止痛，解痉和血压变化特性。

公开(公告)号：US3886168A

公开(公告)日：1975-05-27

申请号：US27345672

申请日：1972-07-20

Applicant: BASF AG

Inventor： HIMMELE WALTER ,  AMANN AUGUST ,  AQUILA WERNER ,  GIERTZ HUBERT ,  SIEGEL HARDO

IPC: C07D295/02 ,  C07D295/03 ,  C07D29/10

CPC classification number: C07D295/03

Abstract: New 1-aminomethylindans and methods of producing them. The compounds are distinguished by their pharmacological effectiveness, particularly by their actions of lowering blood pressure and inhibiting inflammation and by their parasympathicolytic and central nervous system stimulating effects.

Abstract translation: 新的1-氨甲基茚满及其生产方法。 这些化合物的药理学有效性，特别是通过降低血压，抑制炎症和副反应性和中枢神经系统刺激作用的作用来区别。

公开(公告)号：CA1042436A

公开(公告)日：1978-11-14

申请号：CA272966

申请日：1977-03-02

Applicant: BASF AG

Inventor： REICHENEDER FRANZ ,  KROPP RUDOLF ,  AMANN AUGUST ,  GIERTZ HUBERT

IPC: C07D237/10 ,  C07D237/20

Abstract: The present invention relates to new pyridazinium compounds of the general formula (I): (I) where R1 is hydrogen, R2 denotes -NH2, R3 is hydrogen, R4 denotes the radical -SR6, R6 being an alkyl of 1 to 12 carbon atoms, R5 is phenyl and Y.THETA. is an anion of a strong inorganic or organic acid; and their production. Particularly, the above compounds may be used for their circulatory and neuropharmacological effects as well as their analgesic and antiinflammatory effects on animals.

公开(公告)号：AU496840B2

公开(公告)日：1978-11-02

申请号：AU7800875

申请日：1975-02-07

Applicant: BASF AG

Inventor： AMANN AUGUST ,  KOENIG HORST ,  THIEME PETER ,  GIERTZ HUBERT ,  KRETZSCHMAR ROLF

IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P25/08 ,  C07D285/125 ,  C07D91/62 ,  A61K27/00 ,  C07C153/07 ,  C07C161/00

Abstract: 1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R 2 , R 3 , R 4 , R 5 and R 6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R 2 to R 6 being different from hydrogen, and R 1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R 1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R 2 to R 6 are different from hydrogen, or, when R 2 , R 3 , R 5 and R 6 have the above meanings, R 4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R 2 , R 3 , R 4 , R 6 and R 6 is different from H, or (c) R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen when R 1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R 1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R 1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen or R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R 1 NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.

公开(公告)号：CA968800A

公开(公告)日：1975-06-03

申请号：CA151763

申请日：1972-09-14

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  KOENIG HORST ,  AMANN AUGUST ,  GIERTZ HUBERT ,  SCHUSTER JOERG

IPC: C07D237/12 ,  A61K20060101 ,  A61K31/50 ,  C07D20060101 ,  C07D237/04

公开(公告)号：CA1060442A

公开(公告)日：1979-08-14

申请号：CA272964

申请日：1977-03-02

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  AMANN AUGUST ,  GIERTZ HUBERT ,  REICHENEDER FRANZ

IPC: C07D237/10 ,  C07D295/00 ,  C07D403/04

Abstract: The present invention relates to new pyridazinium compounds of the general formula (I): (I) where R1 is hydrogen, R2 denotes -NH2, R3 is hydrogen, R4 denotes the radical -SR6, R6 being an alkyl of 1 to 12 carbon atoms or the radical , the individual radicals R11 being identical or different and denoting hydrogen,alkyl of 1 to 6 carbon atoms, or both radicals R11, together with the nitrogen atom, denoting a pyrrolidine, piperidine or morpholine ring, R5 is phenyl or a lower alkyl, particularly methyl or trifluoromethyl, and ye is an anion of a pharmaceutically acceptable strong inorganic or organic acid; and their production. These compounds have valuable pharmacological properties.

公开(公告)号：CA1060011A

公开(公告)日：1979-08-07

申请号：CA181003

申请日：1973-09-12

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  GIERTZ HUBERT

IPC: C07D237/06 ,  A01N43/58 ,  A61K31/50 ,  A61K31/535 ,  A61P7/10 ,  A61P9/00 ,  A61P9/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/24 ,  A61P25/26 ,  A61P29/00 ,  C07D237/20 ,  G03C1/12 ,  C07D403/04

Abstract: The present invention relates to a process for the production of a pyridazinium compound of the general formula (1) : (1) in which: R1 denotes hydrogen; R2 is alkoxy of 1 to 8 carbon atoms or the radical -NH2; R3 denotes hydrogen or halogen; R4 denotes hydrogen, and alkoxy radical with an alkyl of 5 to 10 carbon atoms, chloro or bromo, OR10 where R10 is alkyl of 5 to 10 carbon atoms, unsubstituted phenyl or phenyl substituted by chloro or methyl, where one R11 is the same as or different from the other R11 and each is hydrogen, phenyl, alkyl of one to six carbon atoms, alkyl of one to six carbon atoms substituted by phenyl, or one R11 together with the other R11 is tetramethylene, pentamethylene or 3-oxatetramethylene; R5 denotes a lower alkyl radical, phenyl or phenyl substituted by chloro or Iower alkyl; and Ye denotes an anion of a pharmaceutically acceptable strong inorganic or organic acid.

公开(公告)号：CA1042435A

公开(公告)日：1978-11-14

申请号：CA272965

申请日：1977-03-02

Applicant: BASF AG

Inventor： REICHENEDER FRANZ ,  KROPP RUDOLF ,  AMANN AUGUST ,  GIERTZ HUBERT

IPC: C07D237/10 ,  C07D237/20

Abstract: The present invention relates to new pyridazinium compounds of the general formula (I): (I) where R1 is hydrogen, R2 is an amino group, R3 is hydrogen, R4 is hydrogen, R5 is unsubstituted phenyl or phenyl substituted by chlorine, and Y.THETA. is an anion of a strong inorganic acid; and their production. Particularly, the above compounds may be used for their circulatory and neuropharmacological effects as well as their analgesic and antiinflammatory effects on animals.

公开(公告)号：AU7800875A

公开(公告)日：1976-08-12

申请号：AU7800875

申请日：1975-02-07

Applicant: BASF AG

Inventor： AMANN AUGUST ,  KOENIG HORST ,  THIEME PETER ,  GIERTZ HUBERT ,  KRETZSCHMAR ROLF

IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P25/08 ,  C07D285/125 ,  A61K27/00 ,  C07D91/62 ,  C07C153/07 ,  C07C161/00

Abstract: 1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R 2 , R 3 , R 4 , R 5 and R 6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R 2 to R 6 being different from hydrogen, and R 1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R 1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R 2 to R 6 are different from hydrogen, or, when R 2 , R 3 , R 5 and R 6 have the above meanings, R 4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R 2 , R 3 , R 4 , R 6 and R 6 is different from H, or (c) R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen when R 1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R 1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R 1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen or R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R 1 NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.