公开(公告)号：CA968800A

公开(公告)日：1975-06-03

申请号：CA151763

申请日：1972-09-14

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  KOENIG HORST ,  AMANN AUGUST ,  GIERTZ HUBERT ,  SCHUSTER JOERG

IPC: C07D237/12 ,  A61K20060101 ,  A61K31/50 ,  C07D20060101 ,  C07D237/04

公开(公告)号：CA990296A

公开(公告)日：1976-06-01

申请号：CA142033

申请日：1972-05-10

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  KOENIG HORST ,  AMANN AUGUST ,  GIERTZ HUBERT ,  SCHUSTER JOERG

IPC: A61K31/50 ,  C07D237/04 ,  C07D295/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: 1386150 6 - Acylaminophenyl - 4,5 - dihydropyridazones BADISCHE ANILINSODAFABRIK AG 10 May 1972 [11 May 1971] 21734/72 Heading C2C Novel 6 - acylamino - 4,5 - dihydropyridazone compounds of general Formula (1): in which R is H or C 1-8 alkyl, and X is an amino or ammonium radical containing directly attached to the N atom at least one C atom but not more than one aromatic ring, and acid addition salts thereof, may be prepared by reacting an amine XH or a trialkylamine with a dihydropyridazone of the Formula (2): which in turn may be prepared by reacting compounds of Formula (4) with compounds of Formula (5) to form compounds of Formula (6) which are then cyclized with hydrazine The novel compounds I exhibit pharmaceutical properties, having the effect of lowering blood pressure, dilating the coronary arteries and combating inflammation.