公开(公告)号：CZ9801242A3

公开(公告)日：1998-07-15

申请号：CZ124298

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  HARTL AXEL PAUL DR ,  HOFMANN JURGEN ,  ROSENBERG JOERG DR ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

公开(公告)号：CZ289689B6

公开(公告)日：2002-03-13

申请号：CZ124298

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  HARTL AXEL PAUL DR ,  HOFMANN JURGEN ,  ROSENBERG JOERG DR ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: The present invention relates to a process for preparing solid multilayer medicaments for oral or rectal administration, which preparation process comprises a) preparation of a first and a second mixtures, each first and second mixture contains thermoplastic and pharmacologically acceptable polymer binding agent that is soluble or swelling in a physiological medium and the first or the second or both the mixtures contain a pharmaceutically active component b) softening or grinding the first and second mixtures, c) passage of the first and second mixtures through a common co-extrusion die, d) extrusion of the first and second mixtures to obtain a co-extruded multilayer material and e) moulding of the co-extruded multilayer material to a desired medicament form.

公开(公告)号：CZ124298A3

公开(公告)日：1998-07-15

申请号：CZ124298

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  HARTL AXEL PAUL DR ,  HOFMANN JURGEN ,  ROSENBERG JOERG DR ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.