公开(公告)号：WO9715293A3

公开(公告)日：1997-08-14

申请号：PCT/EP9604601

申请日：1996-10-23

Applicant: BASF AG ,  BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

Abstract: The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.

公开(公告)号：AT216224T

公开(公告)日：2002-05-15

申请号：AT96937214

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：HRP960483B1

公开(公告)日：2002-02-28

申请号：HRP960483

申请日：1996-10-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTEL AXEL PAUL ,  HOFFMAN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：DE59700547D1

公开(公告)日：1999-11-18

申请号：DE59700547

申请日：1997-08-01

Applicant: BASF AG

Inventor： WUENSCH JOSEF ,  SCHIESSL MICHAEL ,  DIENER RALPH

IPC: C08F4/642 ,  B01J19/20 ,  B01J19/24 ,  C08F4/659 ,  C08F4/6592 ,  C08F12/04 ,  C08F112/00 ,  C08F112/08

Abstract: A process for the production of an essentially syndiotactic and partially crystalline polymer (I) containing vinyl aromatic monomers is claimed. (I) is prepared form a reaction mixture containing vinyl aromatic compounds (II), metallocene complexes (III) and one or co-catalysts (IV) consisting of strong, neutral Lewis acid or Bronsted acid cations. The components are mixed prior to addition to the reactor. An apparatus is also claimed comprising a reservoir to contain a mixture of (II) and (IV), a reservoir to contain (III) plus means to dose the contents of the 2 reservoirs to a pre-mixer that is connected to the reactor vessel.

公开(公告)号：DE59602118D1

公开(公告)日：1999-07-08

申请号：DE59602118

申请日：1996-08-19

Applicant: BASF AG

Inventor： LAY PETER ,  RUECK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL ,  ZETTLER HANS ,  BAUMGAERTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCH JAN ,  HUSEMANN WOLFRAM ,  KAEMPFER KNUT

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08

Abstract: PCT No. PCT/EP96/03633 Sec. 371 Date Jan. 29, 1998 Sec. 102(e) Date Jan. 29, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08231 PCT Pub. Date Mar. 6, 1997A continuous process for preparing bead-form expandable styrene polymers in which the styrene is prepolymerized in bulk to a conversion of 10 to 80%, the prepolymer is dispersed in liquid form in an aqueous phase in the presence of suspension stabilizers, and the polymerization of the prepolymer is completed in an aqueous suspension to a residual styrene content of less than 2000 ppm.

公开(公告)号：NO980736A

公开(公告)日：1998-02-20

申请号：NO980736

申请日：1998-02-20

Applicant: BASF AG

Inventor： LAY PETER NICOLAUS ,  RUECK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL ,  ZETTLER HANS DIETER ,  BAUMGAERTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCK JAN ,  HUSEMANN WOLFRAM ,  KAEMPFER KNUT

IPC: C08J9/16 ,  B01J13/14 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  C08F ,  C08J

CPC classification number: C08F12/08

公开(公告)号：AU7491296A

公开(公告)日：1997-05-15

申请号：AU7491296

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  HARTL AXEL PAUL ,  HOFMANN JURGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：CA2227270A1

公开(公告)日：1997-03-06

申请号：CA2227270

申请日：1996-08-19

Applicant: BASF AG

Inventor： LAY PETER NIKOLAUS ,  BAUMGAERTEL MICHAEL ,  KAEMPFER KNUT ,  HAHN KLAUS ,  HOLOCH JAN ,  DEMBEK GERHARD ,  RUECK SWEN ,  WITT MICHAEL ,  HUSEMANN WOLFRAM ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  C08J9/20 ,  C08L25/04

Abstract: A process is disclosed for continuously producing expandable styrene polymers by polymerising styrene in the presence of expanding agents in three steps: (a) prepolymerising styrene in the mass; (b) dispersing the prepolymer in an aqueous phase; and (c) polymerising the prepolymer in an aqueous suspension.

公开(公告)号：DE59609104D1

公开(公告)日：2002-05-23

申请号：DE59609104

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：DE59702297D1

公开(公告)日：2000-10-05

申请号：DE59702297

申请日：1997-10-28

Applicant: BASF AG

Inventor： BAUMGAERTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCH JAN ,  HUSEMANN WOLFRAM ,  KAEMPFER KNUT ,  LAY PETER ,  RUECK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL

IPC: C08F257/02 ,  C08J9/20