公开(公告)号：DE19706336A1

公开(公告)日：1998-08-20

申请号：DE19706336

申请日：1997-02-19

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM DR ,  KOSER STEFAN DR ,  HOLMANN NICHOLAS JOHN DR

IPC: C07D487/04 ,  C12N9/20 ,  C12P17/18 ,  C12P41/00

Abstract: The invention relates to a method for producing enantiomer-free alcohols of formula (I), where the substituents represent the following: R is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-; R and R independently of each other represent hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, C1-C6-alkanoyl, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; and R is not equal R and independently of each other they represent either hydrogen or a substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms to which they are bound form a substituted or unsubstituted C3-C6-cyclo alkylidene. The method is characterized in that racemic compounds of the formula (II), in which the substituents R to R have the meanings given above and R is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, are reacted with a lipase or esterase in the presence of an alcohol of the formula R OH (III), where R is a substituted or unsubstituted C1-C10-alkyl-.