中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

27 records (took 0.021 seconds)

    3.
    发明专利
    未知

    公开(公告)号：DE19523151A1

    公开(公告)日：1996-08-14

    申请号：DE19523151

    申请日：1995-06-29

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM DR ,  NUEBLING CHRISTOPH DR ,  DITRICH KLAUS DR

    IPC: C12P13/02 ,  C12P41/00 ,  C07C215/44 ,  C07C215/08 ,  C07C217/52 ,  C07C217/10 ,  C07C217/08 ,  C07C231/20 ,  C07C213/08 ,  C07C235/14 ,  C07C235/08 ,  C07B57/00

    Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates is characterised in that (a) a racemic heteroatom-substituted amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bear a fluorine, nitrogen, phosphorus, oxygen or sulphur atom next to the carbonyl carbon atom; (b) the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine is separated in order to produce an enantiomer of the heteroatom-substituted amine; (c) the other enantiomer of the heteroatom-substituted amine is optionally extracted from the acylated heteroatom-substituted amine by amide cleavage.

    4.
    发明专利
    未知

    公开(公告)号：DE4332738A1

    公开(公告)日：1995-03-30

    申请号：DE4332738

    申请日：1993-09-25

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM DR ,  HAUER BERNHARD DR ,  LANDNER WOLFGANG DR ,  PRESSLER UWE DR

    IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38 ,  C07C209/88 ,  C07B57/00

    Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

    New potassium-magnesium L-ascorbate-2-phosphate - recovered as stable, easily processed crystals from ascorbic acid phosphorylation mixt.
    5.
    发明专利
    New potassium-magnesium L-ascorbate-2-phosphate - recovered as stable, easily processed crystals from ascorbic acid phosphorylation mixt. 未知

    公开(公告)号：DE4000977A1

    公开(公告)日：1991-07-18

    申请号：DE4000977

    申请日：1990-01-16

    Applicant: BASF AG

    Inventor： DOBLER WALTER DR ,  BALKENHOHL FRIEDHELM DR ,  BETZ ROLAND DR ,  PAUST JOACHIM DR

    IPC: C07F9/655

    Abstract: K-Mg L-ascorbate-2-phosphate (I) is a new cpd. Pref., it has K:Mg atom ratio 1 +/- 0.3 : 1 +/- 0.15. The salt is prepd. by treating aq. soln. of K L-ascorbate-2-phosphate (III) with a medium-acidity cation exchanger which loses its exchange capacity at pH 2-0.5 to produce a soln. of mono-K salt. This is treated with MgO, Mg(OH)2 or MgCO3 to about pH7 and the soln. opt. treated with MeOH or acetone to ppte. (I). USE/ADVANTAGE - Conversion to (I) is used to recover L-ascorbic acid-2-phosphate (II) from phosphorylation mixt. It is produced free of inorganic salts; in well-crystallisation form which is easy to filter, non-hygroscopic and has little tendency to cake or form dust. The use of a medium-acidity resin produces an eluate which is not strongly acid (so does not decompose the product); MgO consumption and salt discharge are reduced, and regeneration times for the resin are Compared with ascorbic acid itself, (II) is more stable to oxygen, heat and hydrolysis, and has universal bioavailability.

    6.
    发明专利
    未知

    公开(公告)号：DE19706336A1

    公开(公告)日：1998-08-20

    申请号：DE19706336

    申请日：1997-02-19

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM DR ,  KOSER STEFAN DR ,  HOLMANN NICHOLAS JOHN DR

    IPC: C07D487/04 ,  C12N9/20 ,  C12P17/18 ,  C12P41/00

    Abstract: The invention relates to a method for producing enantiomer-free alcohols of formula (I), where the substituents represent the following: R is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-; R and R independently of each other represent hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, C1-C6-alkanoyl, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; and R is not equal R and independently of each other they represent either hydrogen or a substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms to which they are bound form a substituted or unsubstituted C3-C6-cyclo alkylidene. The method is characterized in that racemic compounds of the formula (II), in which the substituents R to R have the meanings given above and R is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, are reacted with a lipase or esterase in the presence of an alcohol of the formula R OH (III), where R is a substituted or unsubstituted C1-C10-alkyl-.

    8.
    发明专利
    未知

    公开(公告)号：DE59106850D1

    公开(公告)日：1995-12-14

    申请号：DE59106850

    申请日：1991-08-16

    Applicant: BASF AG

    Inventor： DOBLER WALTER DR ,  VOSS HARTWIG DR ,  BALKENHOHL FRIEDHELM DR ,  PAUST JOACHIM DR

    IPC: C07F9/09 ,  B01D61/44 ,  C07D307/62 ,  C07F9/655

    Abstract: The invention relates to the preparation of potassium magnesium L-ascorbate-2-phosphate from an aqueous potassium L-ascorbate-2- phosphate solution which is highly contaminated with KCl, as is obtained in the phosphorylation of 5,6-isopropylidene-L-ascorbic acid, by treating the solution with approximately 1 equivalent of magnesium ions per equivalent of L-ascorbate-2-phosphate, followed by removal of the KCl by means of electrodialysis. The process product is a novel L-ascorbate-2-phosphate salt which has very advantageous handling properties.

Patent Agency Ranking