公开(公告)号：DE2245560A1

公开(公告)日：1974-03-21

申请号：DE2245560

申请日：1972-09-16

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR ,  HOPPE DIETER DR ,  HARMS RUEDIGER

IPC: C07D277/12 ,  C07D91/22

Abstract: Cpds. of formula (I): where R1, R2 (opt. identical) is H, opt. unsatd., branched or cyclic and opt. substd. 1-18C alkyl, opt. substd. aromatic or heteroaromatic residues, only one of R1 and R2 being H or CH3; or CR1R2 = 3-18 membered cycloaliphatic or heterocyclic ring; R3 = opt. Ph-substd. 1-7C alkyl esp. Et, are useful as penicillin inters. and are prepd. by reacting beta-substd. alpha-isocyanacrylic esters with H2S at 20-40 degrees C opt. in presence of org. bases.