公开(公告)号：DE3831716A1

公开(公告)日：1990-03-22

申请号：DE3831716

申请日：1988-09-17

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR

IPC: C07K1/02 ,  C07K1/12

Abstract: PCT No. PCT/EP89/01050 Sec. 371 Date Jul. 17, 1990 Sec. 102(e) Date Jul. 17, 1990 PCT Filed Sep. 9, 1989 PCT Pub. No. WO90/03386 PCT Pub. Date Apr. 5, 1990.Process for producing dipeptides from non-proteinogenic amino acids with terminal carbon atoms.

公开(公告)号：DE2245094A1

公开(公告)日：1974-03-21

申请号：DE2245094

申请日：1972-09-14

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR ,  FRASNELLI HUBERT DR ,  BANHIDAI BELA DR ,  MEYER ROLF DIPL CHEM

IPC: C07C45/51 ,  C07B31/00 ,  C07B41/06 ,  C07C45/00 ,  C07C45/72 ,  C07C67/00 ,  C07J41/00 ,  C07J63/00 ,  C07J75/00 ,  C07C49/12

公开(公告)号：DE3928510A1

公开(公告)日：1991-03-07

申请号：DE3928510

申请日：1989-08-29

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR ,  GROTH ULRICH DR ,  LANGE MEINOLF

IPC: C07D241/08

Abstract: Dialkoxy-pyrazine derivs. (I) are new. R1 = methyl and R2 = methyl or R1 = ethyl and R2 = methyl; R3 = methyl, ispropyl, isobutyl, sec.butyl, tert.butyl or benzyl. Prepn. of (I) is by reaction of (II) with HNR5R6 and a Lewis acid to give (III) followed by hydrolysis of prod. (III) and 6-alkylation. R5 = H or 1-6 alkyl. The 6-alkylation is carried out using a trimethyl-or triethyl-oxonium tetrafluoro -borate. USE/ADVANTAGE - Cpds. (I) are intermediates for amino acids and dipeptides. Cpds. (I) are more suitable as intermediates than the symmetrical dialkoxy-pyraxines described in DE 2934252.

公开(公告)号：DE1946550A1

公开(公告)日：1971-03-25

申请号：DE1946550

申请日：1969-09-13

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR ,  GERHART FRITZ DR

IPC: C07C227/16

Abstract: Alpha-Acylaminoacrylic acid esters of formula (I): are prepd. by treating a metallised oxazoline of formula (II): (where R1 and R4 are alkyl, aryl, heteroaryl, aralkyl, R2 and R3 are organic groups or H, but not both H, and M is an alkali metal or an equiv. of Mg, Zn or Cd) with a proton donor. Starting materials (II) may be prepd. by direct metallisn. of the appropriate oxazoline or by condensing a metallised isocyanoacetic acid ester with a carbonyl cpd.

公开(公告)号：DE3525267A1

公开(公告)日：1986-03-20

申请号：DE3525267

申请日：1985-07-16

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR ,  BUSSE ULRICH ,  ACKER ROLF-DIETER DR ,  MEYER NORBERT DR

IPC: A01N57/24 ,  C07F9/30 ,  C07F9/32 ,  C07F9/6509 ,  C07F9/65

Abstract: The invention relates to a process for the preparation of substantially pure enantiomers of (3-amino-3-carboxy-propyl)-alkyl phosphinic acid derivatives by asymmetric synthesis and to herbicidally and bioregulatory active pyrazine derivatives of the formula in which R denotes alkyl, R denotes hydrogen, alkyl or haloalkyl, R denotes hydrogen or alkyl, R denotes hydrogen or alkyl, R denotes hydrogen or alkyl, and R denotes alkyl or benzyl, which are used in this process.t

公开(公告)号：DE2934252A1

公开(公告)日：1981-03-12

申请号：DE2934252

申请日：1979-08-24

Applicant: BASF AG

Inventor： HARTWIG WOLFGANG DR ,  SCHOELLKOPF ULRICH PROF DR

IPC: C07D213/55 ,  C07D215/12 ,  C07D241/08 ,  C07C101/18

Abstract: New processes are claimed for the prodn. of pure or substantially pure optically active alpha-aminoacid derivs. of the formulae Me-C(R1)(NH2)-COOR' (Ia) and R1-CH(NH2)-COOR' (Ib) in which R1 is a non-aromatic organic residue and R' is H or 1-4C alkyl. The first step in the prodn. of (Ia) comprises self-condensation of pure or substantially pure optically active alpha-alanine or its 1-4C alkyl ester to give (R,R)-3,6-dimethyl piperazine-2,5-dione (IIIa) or (S,S)-3,6-dimethylpiperazine-2, 5-dione (IIIb). The first step in the prodn. of (Ib) comprises reaction of glycine or a glycine 1-4C alkyl ester with a pure or substantially pure optically active alpha-methyl-phenylalanine deriv. of the formula Me-C(R2)(NH2)-COOR' (IIc) (where R2 is benzyl opt. substd. in the phenyl residue) to give a 3R- or 3S-3-methyl-3-R2-piperazine-2, 5-dione (IIIc) or (IIId); alternatively, (IIIc) or (IIId) may be prepd.via the corresponding open chain dipeptides by conventional methods. Subsequently, (IIIa)-(IIId) are reacted with an alkylating agent to give a corresponding 2,5-di(1,4-C alkoxy)-3,6-dihydropyrazine deriv.(IVa-d). This is reacted at least an equivalent amount of a strongly basic organometallic cpd. to give a deriv. of (IVa-d) monosubstd. in the 6-position by the metal of the organometallic cpd., and the metal deriv. is reacted with a cpd. R1-Y(V) (where Y is a residue which can be split off as an anion). The resulting deriv. of (IVa-d) substd. in the 6-position by R1 is hydrolysed by means of an acid, and (Ia) or (Ib) is isolated from the hydrolysis mixture by conventional methods. Also claimed are corresponding 2,5-dialkoxy-3,6-dihydro-pyrazine derivs.

公开(公告)号：DE3831717A1

公开(公告)日：1990-03-22

申请号：DE3831717

申请日：1988-09-17

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR

IPC: C07K1/02 ,  C07K1/12

公开(公告)号：DE2245560A1

公开(公告)日：1974-03-21

申请号：DE2245560

申请日：1972-09-16

Applicant: BASF AG

Inventor： SCHOELLKOPF ULRICH PROF DR ,  HOPPE DIETER DR ,  HARMS RUEDIGER

IPC: C07D277/12 ,  C07D91/22

Abstract: Cpds. of formula (I): where R1, R2 (opt. identical) is H, opt. unsatd., branched or cyclic and opt. substd. 1-18C alkyl, opt. substd. aromatic or heteroaromatic residues, only one of R1 and R2 being H or CH3; or CR1R2 = 3-18 membered cycloaliphatic or heterocyclic ring; R3 = opt. Ph-substd. 1-7C alkyl esp. Et, are useful as penicillin inters. and are prepd. by reacting beta-substd. alpha-isocyanacrylic esters with H2S at 20-40 degrees C opt. in presence of org. bases.