公开(公告)号：PT1197483E

公开(公告)日：2005-06-30

申请号：PT01122344

申请日：2001-09-19

Applicant: BASF AG

Inventor： MULLER THOMAS ,  JOHANNES GRIMMER ,  ERNST HANSGEORG

IPC: C07D317/46 ,  A61K31/045 ,  A61K31/12 ,  C07C45/00 ,  C07C45/62 ,  C07C49/743 ,  C07C49/753 ,  C07C403/08 ,  C07D317/00 ,  C07D317/12 ,  C07D317/48 ,  C07F7/18

Abstract: A process is provided for the preparation of cyclohexene derivatives of general formula I or II:in which the substituents R and R independently of one another are defined as follows:R isR is OH or a protective group convertible to a hydroxyl group by hydrolysis;R and R are hydrogen or C1-C4-alkyl; andR is hydrogen or C1-C4-acyl,by the reduction of alkyne compounds of general formula III or IV:in which the substituents R and X are as defined above, wherein the reducing agent used is a mixture of zinc and at least one compound B selected from the group consisting of ammonium salts, copper salts and alkali metal and alkaline earth metal salts.