公开(公告)号：NZ524049A

公开(公告)日：2004-09-24

申请号：NZ52404901

申请日：2001-07-17

Applicant: BASF AG

Inventor： LOCHTMAN RENE ,  KEIL MCIHAEL ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  VON DEYN WOLFGANG

IPC: C07B61/00 ,  C07C319/14 ,  C07C323/62 ,  C07D261/04 ,  C07D413/04 ,  C07C251/40 ,  C07D413/10

Abstract: A process for preparing 4-thioalkylbromobenzene derivatives such as 4-methylthio-3-(4,5-dihydroisoxazol-3-yl)-2-methylbromobenzene of the formula (I) is disclosed, wherein: R1 is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl or a halogen; R2 is C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical; R3 is C1-C6-alkyl; which comprises reacting a compound of the formula (II), in which R1 and R2 are as defined above, with a dialkyl disulfide of the formula (III) in the presence of a nitrite such as sodium nitrite and a catalyst such as copper powder in a suitable solvent. The reaction may be carried out at temperatures between 30-100 degree C